Results 41 to 50 of about 288,388 (279)

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment. [PDF]

PLoS ONE, 2009
BACKGROUND:t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome--Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Xiaomin Zheng, Claudia Oancea, Reinhard Henschler, Malcolm A S Moore, Martin Ruthardt   +4 more
doaj   +1 more source

Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases [PDF]

, 2019
Autoimmune diseases (AID) such as systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS), and rheumatoid arthritis (RA) are chronic inflammatory diseases in which abnormalities of B cell function play a central role.
Bachali, Prathyusha, Catalina, Michelle D., Dörner, Thomas, Grammer, Amrie C., Imgenberg-Kreuz, Juliana, Jungmann, Annemarie, Lino, Andreia C., Lipsky, Peter E., Nordmark, Gunnel, Nordström, Karl, Rincon-Arevalo, Hector, Rönnblom, Lars, Schrezenmeier, Eva, Stefanski, Ana-Luisa, Szelinski, Franziska, Walter, Jörn, Weißenberg, Sarah Y., Welle, Anna, Wiedemann, Annika   +18 more
core   +1 more source

Transmission of ultrafine particles through separating systems of dust samplers

Journal of Sustainable Mining, 2018
In underground mines there is a radiation hazard associated with natural radioactive nuclides. The main sources of radiation exposure in Polish mines are short-lived radon decay products, radioactive mine water containing radium and the sediments ...
Krystian Skubacz
doaj   +1 more source

BCR ubiquitination controls BCR-mediated antigen processing and presentation

Blood, 2006
AbstractBCR-mediated antigen processing occurs at immunologically relevant antigen concentrations and hinges on the trafficking of antigen-BCR (Ag-BCR) complexes to class II–containing multivesicular bodies (MVBs) termed MIICs. However, the molecular mechanism underlying the trafficking of Ag-BCR complexes to and within MIICs is not well understood. In
Lisa, Drake, Erica M, McGovern-Brindisi, James R, Drake   +2 more
openaire   +3 more sources

BCR-ABL affects STAT5A and STAT5B differentially. [PDF]

PLoS ONE, 2014
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors linking extracellular signals to target gene transcription. Hematopoietic cells express two highly conserved STAT5-isoforms (STAT5A/STAT5B), and STAT5
Michael Schaller-Schönitz, David Barzan, Andrew J K Williamson, John R Griffiths, Iris Dallmann, Karin Battmer, Arnold Ganser, Anthony D Whetton, Michaela Scherr, Matthias Eder   +9 more
doaj   +1 more source

TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections. [PDF]

, 2019
In mice, neonatally-developing, self-reactive B-1 cells generate steady levels of natural antibodies throughout life. B-1 cells can, however, also rapidly respond to infections with increased local antibody production. The mechanisms regulating these two
Baumgarth, Nicole, Baumgarth, Nicole, Baumgarth, Nicole, Baumgarth, Nicole, Kläsener, Kathrin, Luo, Zheng, Luo, Zheng, Luo, Zheng, Luo, Zheng, Reth, Michael, Savage, Hannah P, Savage, Hannah P, Savage, Hannah P, Savage, Hannah P, Smith, Fauna L, Smith, Fauna L, Smith, Fauna L, Smith, Fauna L   +17 more
core   +1 more source

Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor treated CML stem cells [PDF]

, 2016
Treatment of chronic myelogenous leukemia (CML) with BCR-ABL tyrosine kinase inhibitors (TKI) fails to eliminate leukemia stem cells (LSC). Patients remain at risk for relapse, and additional approaches to deplete CML LSC are needed to enhance the ...
Agarwal, Puneet, Bhatia, Ravi, Campbell, Victoria L., Chu, Su, Gaal, Karl, Holyoake, Tessa L., Hopcroft, Lisa, Jørgensen, Heather G., Lin, Allen, Zhang, Bin   +9 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Expression of BCR/ABL p210 from a Knockin Allele Enhances Bone Marrow Engraftment without Inducing Neoplasia

Cell Reports, 2013
Chronic myeloid leukemia (CML) and some acute lymphoblastic leukemias are characterized by the t(9;22) chromosome, which encodes the BCR/ABL oncogene. Multiple mouse models of CML express BCR/ABL at high levels from non-Bcr promoters, resulting in the ...
Samantha B. Foley, Zacariah L. Hildenbrand, Abigail A. Soyombo, Jeffery A. Magee, Yipin Wu, Katherine I. Oravecz-Wilson, Theodora S. Ross   +6 more
doaj   +1 more source