Results 241 to 250 of about 99,774 (298)

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Orexin/Hypocretin Modulates Neuroinflammatory Response to LPS in a Sex and Brain-Region Specific Manner in Young Rats. [PDF]

J Neurochem
Frick MA, Woodruff JL, Caudillo YM, Pikel KE, Rehm JV, Maciejewska N, Grillo CA, Reagan LP, Fadel JR.   +8 more
europepmc   +1 more source

Involvement of IL‐13‐Induced Dysregulation of BDNF‐NTRK2 Pathway in Symptoms of Eosinophilic Esophagitis

Allergy, EarlyView.
Kasumi Osonoi, Akinari Sawada, Yuki Maekawa, Mari Yamaguchi, Shingo Yamada, Kazuhiro Matsuyama, Mark Rochman, Marc E. Rothenberg, Xiaobo Han, Naoki Matsuda, Ikuro Suzuki, Fumio Tanaka, Yasuhiro Fujiwara, Tetsuo Shoda   +13 more
wiley   +1 more source

The Black Hole of Immune Checkpoint Blocking Therapy for Gastric Cancer: Hyperprogressive Disease

Cancer Science, EarlyView.
This review summarizes the mechanisms, predictive biomarkers, prevention, and treatment methods of HPD after immune checkpoint blockade therapy, providing a theoretical basis for making a judgment on the efficacy of ICI treatment for gastric cancer.
Zhuan‐Fang Wang, Chen‐Hui Ma, Ewetse Paul Maswikiti, Qin‐Ying Han, Li‐Juan He, Ben Liu, Zhi‐Jian Han, Hao Chen   +7 more
wiley   +1 more source

Effects of arabinoxylan on BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex and intestinal microbiome in post-stroke depressed rats. [PDF]

BMC Neurosci
Bi BY, Lin L, Huang L, Zhou J, Yan WJ, Huang L, Wang J, Li XB.   +7 more
europepmc   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source

The Effects of the Association Between a High-Fat Diet and Physical Exercise on BDNF Expression in the Hippocampus: A Comprehensive Review. [PDF]

Life (Basel)
Gomes FTDS, Andrade AVD, Moura Melo PK, Júnior RRDS, Souza DLS, Tavares ÉAF, Sena IG, Fernandes TAAM, Morais PLAG, Fonseca IAT, Borges CDS, Cavalcanti JRLP.   +11 more
europepmc   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Potential of Nerve Growth Factor (NGF)- and Brain-Derived Neurotrophic Factor (BDNF)-Targeted Gene Therapy for Alzheimer's Disease: A Narrative Review. [PDF]

Cureus
Koya PC, Kolla SC, Madala V, Sayana SB.
europepmc   +1 more source

Regulating the Plasticity of Hippocampal Neurons via Electroacupuncture in Depression Model Mice

Cell Proliferation, EarlyView.
This study explores the regulation of the plasticity of hippocampal neurons via electroacupuncture in corticosterone‐induced depression model mice. Electroacupuncture at the Zusanli (ST36) acupoint alleviated depression‐like symptoms and enhanced neuronal plasticity in the hippocampal CA1 region by upregulating BDNF and CaMKIIβ, highlighting its ...
Yiyang Wang, Xinyi Du, Chenxi Duan, Miaomiao Wang, Ying Zhu, Lihua Wang, Jun Hu, Yanhong Sun   +7 more
wiley   +1 more source