Results 241 to 250 of about 197,182 (311)

The role of BDNF in promoting M2-type macrophage polarization of DRG in glioblastoma with herpes zoster virus infection [PDF]

Yun Cheng, Shuang Fu, Xiaoying Cui, Xiaoyun Ma, Siqi Liu, Bo Chen, Pi-sheng Qu   +6 more
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

The Convergence of Early-Life Stress and Autism Spectrum Disorder on the Epigenetics of Genes Key to the HPA Axis. [PDF]

Biology (Basel)
Han E, Canada KA, Puglia MH, Pelphrey KA, Evans TM.   +4 more
europepmc   +1 more source

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Kinetics of Norepinephrine- and Serotonin-Induced BDNF Release in Cultured Embryonic Hippocampal Neurons

, 2013
Michael Chen, Amelia Russo‐Neustadt
openalex   +2 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Effect of Ang II Receptor Inhibition on GSK-3β/CREB/BDNF Signalling in REM Sleep Deprivation-Induced Memory Impairment. [PDF]

Neurochem Res
Elma N, Sayan Özaçmak H, Turan İ.
europepmc   +1 more source

The influence of vegetarian diets on the nutritional status, biochemical parameters and the expression of circulating brain-derived neurotrophic factor (BDNF) among adults in the city of São Paulo

, 2014
Carolina Vieira de Mello Barros Pimentel
openalex   +1 more source

Myeloid PD‐1 Regulates Astrocyte Development and Leads to Active Behaviours

Cell Proliferation, EarlyView.
During early neurodevelopment, PD‐1 ablation in myeloid cells influences myeloid proliferation/differentiation and causes sustained astrocyte overproliferation. PD‐1f/f; LysM‐Cre mice showed elevated astrocyte gene expression and behavioural changes.
Jie Qin, Chong Wang, Sihan Li, Yanyan Wang, Tingting He, Jianwei Jiao, Fen Ji   +6 more
wiley   +1 more source

The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications. [PDF]

Ann Med
Li Y, Lu Y, Lin X, Zhao L.
europepmc   +1 more source