Results 251 to 260 of about 99,774 (298)

Concomitant Increases in Brain-Derived Neurotrophic Factor and Lactate Post-Exercise Do Not Demonstrate a Direct Correlation. [PDF]

J Neurosci Res
Ashcroft SK, Basclain K, Woolnough C, Hoon MW, Walsh SJ, Starc LC, Johnson L, Kuys SS, Thompson-Butel AG.   +8 more
europepmc   +1 more source

Myeloid PD‐1 Regulates Astrocyte Development and Leads to Active Behaviours

Cell Proliferation, EarlyView.
During early neurodevelopment, PD‐1 ablation in myeloid cells influences myeloid proliferation/differentiation and causes sustained astrocyte overproliferation. PD‐1f/f; LysM‐Cre mice showed elevated astrocyte gene expression and behavioural changes.
Jie Qin, Chong Wang, Sihan Li, Yanyan Wang, Tingting He, Jianwei Jiao, Fen Ji   +6 more
wiley   +1 more source

Neurophysiological mechanisms underlying cardiovascular adaptations to exercise: A narrative review. [PDF]

Physiol Rep
Omole JG, Okon IA, Udom GJ, Aziakpono OM, Agbana RD, Aturamu A, Niwamanya N, Oritsemuelebi B, Etukudo EM, Yemitan OK.   +9 more
europepmc   +1 more source

kcnb1 loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ‐aminobutyric acid dysregulation

Epilepsia, EarlyView.
Abstract Objective KCNB1 encodes an α‐subunit of the delayed‐rectifier voltage‐dependent potassium channel Kv2.1. De novo pathogenic variants of KCNB1 have been linked to developmental and epileptic encephalopathies (DEEs), diagnosed in early childhood and sharing limited treatment options.
Lauralee Robichon, Claire Bar, Anca Marian, Lisa Lehmann, Solène Renault, Edor Kabashi, Sorana Ciura, Rima Nabbout   +7 more
wiley   +1 more source

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment

Epilepsia, EarlyView.
Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones, Silvia Lindlar, Johannes Ludwig, Regina Waltes, Afsheen Kumar, Sophie v. Brauchitsch, Andrea Rossi, Evelyn Ullrich, Stefan Momma, Christine M. Freitag, Jasmin K. Hefendehl, Karl Martin Klein, Felix Rosenow, Denise Haslinger, Andreas G. Chiocchetti   +14 more
wiley   +1 more source

Chronic postoperative pain induces contextual fear extinction dysfunction through hippocampal NMDAR/BDNF/TrkB signaling pathway in mice. [PDF]

Transl Psychiatry
Zhang J, Zheng X, Zhang G, Cheng Z, Liu Y, Zhang L, Zhang J, Liu X, Yang Z.   +8 more
europepmc   +1 more source

Electrical stimulation of stem cell–derived human neural networks for evaluating anti‐seizure medications

Epilepsia, EarlyView.
Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls, Jinchao Gu, Zhibin Chen, Zikou Liu, Ana Antonic‐Baker, Muhammad Shahid Javaid, Eliza Moore, Hailin Zhu, Afaf Altalhi, David K. Wright, Huseyin Sumer, Terence J. O'Brien, Patrick Kwan, Ben Rollo   +13 more
wiley   +1 more source

The effect of quercetin on obesity and reproduction through the expression of genes involved in the hypothalamus-pituitary-gonadal axis. [PDF]

JBRA Assist Reprod
Shams E, Zohrabi D, Omrani O, Sanati MH, Karimi-Dehkordi M, Yazdanpanahi N, Moghadam FK, Zarezade V.   +7 more
europepmc   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source

Tandem Mass Tags Quantitative Proteomics Reveal the Mechanism by Which Paeoniflorin Regulates the PI3K/AKT and BDNF/CREB Signaling Pathways to Inhibit Parkinson's Disease. [PDF]

Int J Mol Sci
Feng Z, Jin C, Zhang Y, Xue H, Ai Y, Wang J, Zheng M, Shi D.   +7 more
europepmc   +1 more source