Results 21 to 30 of about 24,253,925 (274)
USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity
Nature Communications, 2022 Non-small cell lung cancers (NSCLC) frequently contain KRAS mutation but retain wild-type TP53. Abundant senescent cells are observed in premalignant but not in malignant tumors derived from the Kras-driven mouse model, suggesting that KRAS oncogenic ...
Juan Li +15 more
semanticscholar +1 more source
The Beclin 1 interactome [PDF]
Current Opinion in Cell Biology, 2010 The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases.
Congcong, He, Beth, Levine
openaire +2 more sources
Beclin 1 deficiency correlated with lymph node metastasis, predicts a distinct outcome in intrahepatic and extrahepatic cholangiocarcinoma. [PDF]
PLoS ONE, 2013 Autophagy can be tumor suppressive as well as promotive in regulation of tumorigenesis and disease progression. Accordingly, the prognostic significance of autophagy key regulator Beclin 1 was varied among different tumors.
Tian-Tian Wang +17 more
doaj +1 more source
Stem Cells Translational Medicine, 2022 The development of osteoporosis is often accompanied by autophagy disturbance, which also causes new osteoblast defects from bone marrow mesenchymal stem cells (BMSCs).
Mingyu He +18 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 A growing body of evidence suggests that neutrophil extracellular traps (NETs) critically contribute to the development of atherosclerosis. However, the detailed mechanism of how NETs promote atherogenesis remains unknown.
Masataka Sano +7 more
semanticscholar +1 more source
The FASEB Journal, 2022 Inflammatory bowel disease (IBD) represents a set of idiopathic and chronic inflammatory diseases of the gastrointestinal tract. Central to the pathogenesis of IBD is a dysregulation of normal intestinal epithelial homeostasis.
Sidrah Khan +12 more
semanticscholar +1 more source
Role for autophagy-related markers Beclin-1 and LC3 in endometriosis
BMC Women's Health, 2022 Background Endometriosis is a common and challenging disease in women of childbearing age with high personal and social costs. Many molecular differences between ectopic and eutopic endometrium present difficulties in the development of new drug ...
Zhiwei Kong, Tingting Yao
semanticscholar +1 more source
Regulation of Beclin 1 in autophagy [PDF]
Autophagy, 2009 Class III phosphatidylinositol 3-kinase (PI3KC3) plays a pleiotropic role in autophagy and protein sorting pathways. The human core complex of PI3KC3 consists of three major components including PI3KC3/hVps34, p150 and Beclin 1. How the specificity of PI3KC3 complex is derived towards autophagy is not clear. Utilizing a sequential affinity purification
Qiming, Sun, Weiliang, Fan, Qing, Zhong
openaire +2 more sources
Acta Pharmaceutica Sinica B, 2023 Beclin-1 is the firstly-identified mammalian protein of the autophagy machinery, which functions as a molecular scaffold for the assembly of PI3KC3 (class III phosphatidylinositol 3 kinase) complex, thus controlling autophagy induction and other cellular
Jing Ye +6 more
doaj +1 more source
JCI Insight, 2021 The mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of acetaldehyde and endogenous lipid aldehydes. Approximately 40% of East Asians, accounting for 8% of the human population, carry the E504K mutation in ALDH2 that ...
Tonghui Xu +14 more
semanticscholar +1 more source