Results 11 to 20 of about 46,670 (237)
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration [PDF]
Molecular Neurodegeneration, 2018 Background Neuronal cell loss contributes to the pathology of acute and chronic neurodegenerative diseases, including Alzheimer’s disease (AD). It remains crucial to identify molecular mechanisms sensitizing neurons to various insults and cell death.
Gregor Bieri +5 more
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Beclin 1, LC3 and P62 Expression in Equine Sarcoids [PDF]
Animals, 2021 Background: It is well known that δ-bovine papillomaviruses (BPV-1, BPV-2 and BPV-13) are one of the major causative agents of equine sarcoids, the most common equine skin tumors.
Manuela Martano +6 more
doaj +4 more sources
Beclin-1 Targeting for Viral Immune Escape [PDF]
Viruses, 2011 Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4+ T cells.
Christian Münz
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VCP/p97 regulates Beclin-1-dependent autophagy initiation [PDF]
Nature Chemical Biology, 2021 Autophagy is an essential cellular process that removes harmful protein species, and autophagy upregulation may be able to protect against neurodegeneration and various pathogens. Here, we have identified the essential protein VCP/p97 as a novel regulator of autophagosome biogenesis, where VCP regulates autophagy induction in two ways, both dependent ...
Sandra M. Hill +6 more
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The Beclin 1 interactome [PDF]
Current Opinion in Cell Biology, 2010 The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases.
Congcong, He, Beth, Levine
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Common and divergent functions of Beclin 1 and Beclin 2 [PDF]
Cell Research, 2013 In a recent paper published in Cell, He and colleagues reported the identification and functional characterization of Beclin 2, a mammal-specific homolog of the evolutionarily conserved autophagy-regulatory and oncosuppressive factor Beclin 1. In spite of a non-negligible degree of sequence identity, Beclin 1 and Beclin 2 differ from each other in ...
Lorenzo, Galluzzi, Guido, Kroemer
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Regulation of Beclin 1 in autophagy [PDF]
Autophagy, 2009 Class III phosphatidylinositol 3-kinase (PI3KC3) plays a pleiotropic role in autophagy and protein sorting pathways. The human core complex of PI3KC3 consists of three major components including PI3KC3/hVps34, p150 and Beclin 1. How the specificity of PI3KC3 complex is derived towards autophagy is not clear. Utilizing a sequential affinity purification
Qiming, Sun, Weiliang, Fan, Qing, Zhong
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Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer. [PDF]
PLoS ONE, 2013 Beclin 1, a key regulator of autophagy, has been found to be aberrantly expressed in a variety of human malignancies. Herein, we employed immunohistochemistry (IHC) to detect the protein expression of Beclin 1 in non-small cell lung cancer (NSCLC) and ...
Weihua Zhou +11 more
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Neurodegeneration Induces Upregulation of Beclin 1 [PDF]
Autophagy, 2006 Autophagy, a bulk degradation of subcellular constituents, is activated in normal cell growth and development, and represents the major pathway by which the cell maintains a balance between protein synthesis and protein degradation. Autophagy was documented in several neurodegenerative diseases, and under stress conditions the autophagic process can ...
Shlomit, Erlich +2 more
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Autophagy processes are dependent on EGF receptor signaling [PDF]
, 2018 Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina +12 more
core +1 more source