Ecotoxicology and Environmental Safety, 2022 Arsenite is a toxic metalloid that causes various adverse effects in brain. However, the underlying mechanisms of arsenite-induced neurotoxicity remain poorly understood.
Hongmei Zhou +10 more
doaj +1 more source
Targeting Beclin 1 for viral subversion of macroautophagy [PDF]
Autophagy, 2010 We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell.
Gannagé Monique +2 more
openaire +4 more sources
Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia
Haematologica, 2020 Autophagy is a genetically regulated process of adaptation to metabolic stress and was recently shown to be involved in the treatment response of chronic myeloid leukemia (CML).
Chuanjiang Yu +14 more
doaj +1 more source
The Expression of The Autophagy Gene Beclin-1 mRNA and Protein in Ectopic and Eutopic Endometrium of Patients with Endometriosis [PDF]
International Journal of Fertility and Sterility, 2015 Background To investigate the expression of Beclin-1 mRNA and protein in eutopic and ectopic endometrium of women with and without endometriosis, and evaluate the association of Beclin-1 protein expression and serum CA125 levels in the endometriosis ...
Longyu Zhang +4 more
doaj +1 more source
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. [PDF]
, 2018 SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as a potential therapeutic target in a variety of neurodegenerative diseases, including Parkinson's disease (PD ...
Deng, Yong-Ning +6 more
core +1 more source
Beclin 1 bridges autophagy, apoptosis and differentiation [PDF]
Autophagy, 2008 Beclin 1 is a critical component in the class III PI3 kinase complex (PI3KC3) that induces the formation of autophagosomes in mammalian systems. Autophagic triggers upregulate Beclin 1, which in turn binds to PI3KC3 or Bcl-X(L) to form complexes of Beclin 1-PI3KC3 or Beclin 1-Bcl-X(L) that are physically and functionally independent from each other ...
openaire +2 more sources
eLife, 2015 Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins. However, the cellular cues that activate the function of ATG proteins during amino acid starvation are ...
Yongjie Wei +8 more
doaj +1 more source
Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG. [PDF]
PLoS ONE, 2017 Anti-apoptotic Bcl-2 and Bcl-xL are proposed to regulate starvation-induced autophagy by directly interacting with Beclin 1. Beclin 1 is also thought to be involved in multiple vesicle trafficking pathways such as endocytosis by binding to Atg14L and ...
Shintaro Nakajima +5 more
doaj +1 more source
BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development [PDF]
Cell Death & Differentiation, 2008 Beclin 1/Atg6 is an essential component of the evolutionary conserved PtdIns(3)-kinase (Vps34) protein complex that regulates macroautophagy (autophagy) in eukaryotic cells and also interacts with antiapoptotic Bcl-2 family members, Bcl-2, and Bcl-x(L).
Arsov, I +7 more
openaire +3 more sources
Autophagy plays a protective role against Trypanosoma cruzi infection in mice
Virulence, 2019 Autophagy is a catabolic pathway required for cellular and organism homeostasis. Autophagy participates in the innate and adaptive immune responses at different levels.
Ana Florencia Casassa +4 more
doaj +1 more source