Results 81 to 90 of about 46,670 (237)
TREM2-dependent effects on microglia in Alzheimer\u27s Disease [PDF]
, 2018 Alzheimer’s disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits.
Colonna, Marco +2 more
core +3 more sources
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara +5 more
wiley +1 more source
BECLIN 1 - Регулаторен протеин на автофагията
Varna Medical Forum, 2017 Изучаването на пропатогенните ефекти на автофагията е сравнително нова област на из- следване, показваща, че тя може да упражни многофункционални патогенетични роли, свър- зани с клетъчното оцеляване или смърт. Нару- шенията в процесите на автофагия предизвик- ват чувствителност към метаболитен стрес, геномно увреждане, неконтролирана клетъчна ...
Kameliya Bratoeva +7 more
openaire +2 more sources
Involvement of Beclin 1 in Engulfment of Apoptotic Cells [PDF]
Journal of Biological Chemistry, 2012 Efficient apoptotic cell engulfment is important for both tissue homeostasis and immune response in mammals. In the present study, we report that Beclin 1 (a regulator of autophagy) is required for apoptotic cell engulfment. The engulfment process was largely abolished in Beclin 1 knock-out cells, and Beclin 1 knockdown significantly decreased ...
Akimitsu, Konishi +3 more
openaire +2 more sources
Expression levels and clinical significance of autophagy related proteins in placenta tissues of pregnant women with fetal growth restriction [PDF]
Jichu yixue yu linchuangObjective To explore the expression and clinical significance of autophagy related proteins Beclin-1, microtubule-associated protein 1 light chain 3(LC3) in placenta tissues of pregnant women with fetal growth restriction(FGR).
ZHANG Yuling, ZHANG Ke, XU Ting, ZHANG Qing
doaj +1 more source
Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]
, 2016 Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith +6 more
core +2 more sources
Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment
BMEMat, EarlyView.Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan +8 more
wiley +1 more source
An autophagy-independent function of Beclin 1 in cancer [PDF]
Molecular & Cellular Oncology, 2015 The involvement of Beclin 1 in cancer has been attributed primarily to its role in autophagy initiation. Our recent findings identify a novel, alternative mechanism by which Beclin 1 can impact tumor progression, through the regulation of growth factor receptor signaling.
Rohatgi, Rasika, Shaw, Leslie M.
openaire +3 more sources
Neuroprotection targeting protein misfolding on chronic cerebral hypoperfusion in the context of metabolic syndrome [PDF]
, 2018 Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH
Capani, Francisco +6 more
core +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source