Results 111 to 120 of about 33,833 (238)

Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis

Antimicrobial Agents and Chemotherapy
The combination of bedaquiline, pretomanid, and linezolid (BPaL) has become a preferred regimen for treating multidrug- and extensively drug-resistant tuberculosis (TB).
Si-yang Li, S. Tyagi, H. Soni, Fabrice Betoudji, P. Converse, K. Mdluli, A. Upton, N. Fotouhi, David Barros-Aguirre, Lluís Ballell, Elena Jiménez-Navarro, E. Nuermberger   +11 more
semanticscholar   +1 more source

Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials [PDF]

, 2015
Supported by the European and Developing Country Clinical Trials Partnership (grant IP.2007.32011.011) and the Global Alliance for TB Drug Development, with support from the Bill & Melinda Gates Foundation, US Agency for International Development, UK ...
Phillips, Patrick P. J., Mendel, Carl M., Burger, Divan A., Crook, Angela, Nunn, Andrew J., Dawson, Rodney, Diacon, Andreas H., Gillespie, Stephen Henry   +7 more
core   +1 more source

Cost-effectiveness of adding bedaquiline to drug regimens for the treatment of multidrug-resistant tuberculosis in the UK.

PLoS ONE, 2015
ObjectiveTo evaluate the cost-effectiveness of adding bedaquiline to a background regimen (BR) of drugs for multidrug-resistant tuberculosis (MDR-TB) in the United Kingdom (UK).MethodsA cohort-based Markov model was developed to estimate the incremental ...
Lara J Wolfson, Anna Walker, Robert Hettle, Xiaoyan Lu, Chrispin Kambili, Andrew Murungi, Gerhart Knerer   +6 more
doaj   +1 more source

Linking genetic and phenotypic bedaquiline resistance in Mycobacterium tuberculosis strains from Georgia.

PLoS ONE
IntroductionResistance to bedaquiline - a novel, promising medication against tuberculosis (TB), is already emerging, and uncertainties regarding the role of the different resistance-conferring mutations complicate the development of molecular diagnostic
Nino Maghradze, Chloé Loiseau, Galo Adrian Goig, Nino Bablishvili, Levan Jugheli, Sonia Borrell, Nestani Tukvadze, Russell Ryan Kempker, Zaza Avaliani, Sebastien Gagneux   +9 more
doaj   +1 more source

Effectiveness and safety of regimen containing bedaquiline and delamanid in patients with drug-resistant tuberculosis

Perspectives in Clinical Research
Background: Bedaquiline and delamanid have been included in the individualized treatment regimen (ITR) to treat patients with drug-resistant tuberculosis (DR-TB).
Oki Nugraha Putra, Yulistiani Yulistiani, Soedarsono Soedarsono, Susi Subay   +3 more
doaj   +1 more source

Improvement in Outcomes with a New Bedaquiline-based Regimen in Postoperative Cases of Drug-resistant Tuberculosis of the Spine: A Case Series [PDF]

Journal of Clinical and Diagnostic Research
The incidence of drug-resistant strains of Tuberculosis (TB) is rising at an alarming rate. With the emergence of newer drug-resistant strains, managing the disease with existing antitubercular agents is becoming increasingly difficult. Few studies exist
Soutrik Kundu, Sarvan Singh
doaj   +1 more source

The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes [PDF]

, 2018
The Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical OutcomesThe already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human
Abel, Aguilar, Alangari, Albanna, Alisjahbana, Armitage, Asante-Poku, Asante-Poku, Azad, Baker, Barry, Bastos, Bates, Benard, Berg, Bhat, Bilaçeroglu, Brites, Bustamante, Cambier, Campbell, Carmona, Caws, Cegielski, Cegielski, Chambers, Chatterjee, Clarke, Cohen, Coleman, Comas, Comas, Copin, Coscolla, Coussens, Critchley, Curtis, da Silva, Daya, de Jong, de Wit, Deffur, Deretic, Desvignes, Diedrich, Divangahi, Dormans, Dunn, Esmail, Evans, Ford, Gagneux, Gauguet, Gehre, George, Givi, Gonzalo-Asensio, Grant, Gupta, Gurjav, Hassan, Hershberg, Hirsh, Hodgson, Huempfner, Inghammar, Intemann, Jeon, Jeremiah, Jiménez-Corona, Jurado, Kato-Maeda, Kerkhoff, Khan, Kim, Kimmey, Kong, Kong, Krishnan, Kwan, Lan, Lari, Larsen, Lee, Leistikow, Lin, Lin, Lin, Liu, López, Maiga, Majlessi, Manca, Manca, Manca, Marakalala, Martineau, Martineau, Martineau, Martinez, Mayanja-Kizza, Mayer-Barber, Mayer-Barber, Meyer, Mily, Moreira-Teixeira, Omae, Osório, O’Garra, O’Leary, Pareek, Parihar, Parwati, Pepperell, Perry, Portevin, Pérez-Lago, Qu, Rahman, Redford, Reed, Resende, Restrepo, Robbins, Ronacher, Salie, Sarkar, Scalcini, Schiebler, Schuijt, Sethi, Shaler, Singh, Singhal, Skrahin, Slama, Sonnenberg, Sow, Stavrum, Stucki, Sun, Sun, Taylor, Thuong, Thye, Tobin, Via, Vilaplana, Viswanathan, Wallis, Walter, Wang, Winglee, Wollenberg, Yruela, Zak, Zumla   +156 more
core   +3 more sources

Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: a systematic review and individual isolate meta-analysis

The Lancet Microbe
Summary Background Clinical bedaquiline resistance predominantly involves mutations in mmpR5 (Rv0678). However, mmpR5 resistance-associated variants (RAVs) have a variable relationship with phenotypic Mycobacterium tuberculosis resistance.
Camus Nimmo, N. Bionghi, Matthew J. Cummings, R. Perumal, Madeleine Hopson, S. Al Jubaer, K. Naidoo, A. Wolf, B. Mathema, M. Larsen, Max O’Donnell   +10 more
semanticscholar   +1 more source

2016 Pipeline Report HIV and TB [PDF]

, 2016
HIV and TB: Drugs, Diagnostics, Vaccines, Preventive Technologies, Research Toward a Cure, and Immune-Based and Gene Therapies in ...
Erica Lessem, Lindsay McKenna, Mark Harrington, Mike Frick, Polly Clayden, Richard Jefferys, Simon Collins, Tim Horn   +7 more
core  

Non-tuberculous mycobacterial pulmonary infections [PDF]

, 2017
Submitted by Sandra Infurna (sandra.infurna@ioc.fiocruz.br) on 2019-05-14T13:52:47Z No. of bitstreams: 1 ACC_Caravalho_IOC_2018.pdf: 454431 bytes, checksum: 86468a62313ad15880a6ccff685e3090 (MD5)Approved for entry into archive by Sandra Infurna (sandra.
Agusti, Ahn, Aksamit, Albert, Albrecht, Aliberti, Aliberti, Andréjak, Barnes, Bastian, Bax, Becker, Bolhuis, Brode, Browne, Bryant, Burgel, Calverley, Cassidy, Cazabon, Chalmers, Chalmers, Chalmers, Chalmers, Chalmers, Chalmers, Chen, Chu, Colombo, Contoli, Dalcolmo, Dicker, Diel, Diel, Dilokthornsakul, Donohue, El-Zeenni, Elborn, Ellender, Faverio, Finch, Fleshner, Fletcher, Floto, Goeminne, Griffith, Griffith, Griffith, Griffith, Guglielmetti, Haas, Halstrom, Halstrom, Haworth, Henkle, Henkle, Henkle, Hill, Hoefsloot, Hwang, Kang, Kartalija, Kim, Kim, Kim, King, Koh, Krieger, Kunst, Kwak, Kwon, Lai, Lam, Larsson, Loebinger, Lonni, Lucas, Lyu, Marras, Matsuyama, McDonnell, McDonnell, Morimoto, Namkoong, Nash, Oliveira, Olivier, Pedro, Pezzia, Philley, Polverino, Pym, Quint, Qvist, Ringshausen, Rossouw, Roux, Salsgiver, Shah, Shah, Shallom, Shen, Sherrard, Shiraishi, Slaats, Sotgiu, Stout, Suarez-Cuartin, Suzuki, Szymanski, Tadolini, Tettelin, Tortoli, van Ingen, van Ingen, Van Kampenhout, Vesenbeckh, Vogelmeier, Wallace, Wallace, Winthrop, Winthrop, Winthrop, Yagi, Yeung, Yoo, Yu   +126 more
core   +4 more sources