Results 91 to 100 of about 28,367 (198)

Cost-effectiveness of adding bedaquiline to drug regimens for the treatment of multidrug-resistant tuberculosis in the UK.

PLoS ONE, 2015
ObjectiveTo evaluate the cost-effectiveness of adding bedaquiline to a background regimen (BR) of drugs for multidrug-resistant tuberculosis (MDR-TB) in the United Kingdom (UK).MethodsA cohort-based Markov model was developed to estimate the incremental ...
Lara J Wolfson, Anna Walker, Robert Hettle, Xiaoyan Lu, Chrispin Kambili, Andrew Murungi, Gerhart Knerer   +6 more
doaj   +1 more source

Long-term bedaquiline-related treatment outcomes in patients with extensively drug-resistant tuberculosis from South Africa

, 2018
Optimal treatment regimens for patients with extensively drug-resistant tuberculosis (XDR-TB) remain unclear. Long-term prospective outcome data comparing XDR-TB regimens with and without bedaquiline from an endemic setting are lacking.We prospectively ...
Rob Warren, Aliasgar Esmail, Mohammed Fadul, Olatunde Olayanju, Phindile Gina, Suzette Oelofse, Elize Pietersen, Keertan Dheda, Jason Limberis   +8 more
core   +1 more source

Online service for interpretation of the resistance prediction results to bedaquiline by the molecular data

Acta Biomedica Scientifica
Background. Bedaquiline is a new and promising anti-tuberculosis drug, but longterm use requires resistance. This is due to mutations in the atpE and mmpR genes in M.
V. V. Sinkov, I. G. Kondratov, O. B. Ogarkov, S. N. Zhdanova, A. P. Noskov, P. A. Khromova, E. A. Orlova, A. V. Labygina, L. V. Rychkova, L. I. Kolesnikova   +9 more
doaj   +1 more source

New synthetic approaches towards analogues of bedaquiline

, 2016
Multi-drug resistant tuberculosis (MDR-TB) is of growing global concern and threatens to undermine increasing efforts to control the worldwide spread of tuberculosis (TB). Bedaquiline has recently emerged as a new drug developed to specifically treat MDR-
L Barbaro (13653031), JB Baell (11036820), DL Priebbenow (15870668)   +2 more
core  

New drugs to treat multidrug-resistant tuberculosis: the case for bedaquiline

Therapeutics and Clinical Risk Management, 2014
Eric Leibert, Mauricio Danckers, William N Rom Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY, USA Abstract: Mycobacterium tuberculosis develops spontaneous ...
Leibert E, Danckers M, Rom WN
doaj  

Efficacy and safety of bedaquiline containing regimens in patients of drug-resistant tuberculosis: An updated systematic review and meta-analysis

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and leads to serious complications if left untreated. Some strains of Mycobacterium tuberculosis are multi-drug resistant and require treatment with newer drugs ...
Obaid Ur Rehman, Eeshal Fatima, Abraish Ali, Umar Akram, Abdulqadir Nashwan, Faryal Yunus   +5 more
doaj   +1 more source

In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China

, 2017
The main goal of our study was to evaluate the in vitro bedaquiline susceptibility of six prevalent species of pathogenic nontuberculous mycobacteria (NTM) in China.
Yaoju Tan, Yuanyuan Song, Yu Pang, Huiwen Zheng, Yanlin Zhao   +4 more
core   +1 more source

Relative bioavailability of bedaquiline tablets suspended in water : Implications for dosing in children

, 2018
Aims: Bedaquiline is an important novel drug for treatment of multidrug-resistant tuberculosis, but no paediatric formulation is yet available. This work aimed to explore the possibility of using the existing tablet formulation in children by evaluating ...
Diacon, Andreas H.,, Nachman, Sharon, Kitshoff, Rene,, Garcia-Prats, Anthony J., Kitshoff, Rene, Svensson, Elin, Norman, Jennifer, de Jager, Veronique R., Diacon, Andreas H., Hesseling, Anneke C.,, Garcia-Prats, Anthony J.,, Smith, Betsy,, Nachman, Sharon,, Smith, Betsy, du Bois, Jeannine,, Wiesner, Lubbe,, Svensson, Elin,, Wiesner, Lubbe, Hesseling, Anneke C., du Bois, Jeannine, de Jager, Veronique R.,, Norman, Jennifer,   +21 more
core   +1 more source

Bedaquiline [PDF]

, 2020
openaire   +1 more source

Peran bedaquiline untuk tuberkulosis resisten obat: A literature review

Background: Multidrug-resistant tuberculosis (MDR/RR-TB) is a serious challenge in global TB elimination efforts. Indonesia as a country with a high TB ​​burden faces the problem of MDR/RR-TB therapy, where the effectiveness of second-line treatment is ...
Darmanto, Arief Gunawan, Dewi, Desak Nyoman Surya Suameitria   +1 more
core   +1 more source