Results 71 to 80 of about 28,367 (198)

Bedaquiline for the treatment of drug-resistant tuberculosis

, 2015
Bedaquiline is a much-needed novel drug which is highly effective against drug-resistant tuberculosis. While its clinical development has been laudably fast-tracked and the drug is now available for inclusion into treatment regimens when no suitable ...
Heuvelings, Charlotte C., Grobusch, Martin P., Bélard, Sabine, Janssen, Saskia   +3 more
core   +1 more source

Efficacy and safety of chemotherapy regimens with bedaquiline in patients with respiratory tuberculosis: immediate and final results

Туберкулез и болезни лёгких, 2019
The objective of the study: to determine the efficacy and safety of chemotherapy regimens with bedaquiline in patients with respiratory tuberculosis in the context of everyday clinical practice with minimal non-inclusion criteria.
S. E. Borisov, A. V. Filippov, D. A. Ivanova, T. N. Ivanushkina, N. V. Litvinova, Yu. Yu. Garmash   +5 more
doaj   +1 more source

Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers

Advanced Science, Volume 13, Issue 21, 13 April 2026.
MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao, Cheng Lu, Hao Chen, Jing Zhou, Yunyun Hu, Haonan Di, Guoqiang Su, Xiaomei Yan   +7 more
wiley   +1 more source

Determination of Bedaquiline in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry [PDF]

, 2015
Bedaquiline, a diarylquinoline for the treatment of multidrug-resistant tuberculosis (TB), relies on exposure-dependent killing. As data on drug exposure in specific populations are scarce, pharmacokinetic studies may be of interest. No simple and robust
Bolhuis, Mathieu, Alffenaar, Jan-Willem C., Akkerman, Onno; id_orcid, Akkerman, Onno, Greijdanus, Ben, Touw, Daan; id_orcid, van Hateren, Kai, Touw, Daan, Sturkenboom, Marieke, Sturkenboom, Marieke; id_orcid, de Lange, Wiel, van der Werf, Tjip   +11 more
core   +1 more source

Long-term impact of the adoption of bedaquiline-containing regimens on the burden of drug-resistant tuberculosis in China

BMC Infectious Diseases, 2020
Background Currently available injectable agents are inadequate to address the high drug-resistant tuberculosis (DR-TB) burden in China. Regimens including the oral agent bedaquiline have been shown to be efficacious and safe, leading to its ...
Abela Mpobela Agnarson, Xiao Chun Wang, Ravi Potluri, Hitesh Bhandari, Amit Dhir, Chrispin Kambili, Laurent Metz   +6 more
doaj   +1 more source

Population pharmacokinetics of TBAJ‐587 and its main metabolites—Evaluation of different loading dose strategies and early dose selection

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1058-1068, April 2026.
Background and Aim The rise of drug‐resistant tuberculosis (TB) poses a need for new drugs and combinations. TBAJ‐587, a new diarylquinoline (DARQ), has shown promising efficacy in preclinical studies. This work aimed to describe the pharmacokinetics (PK) of TBAJ‐587 and its metabolites M2 and M3 after single ascending dosing in healthy volunteers and ...
Albin A. M. Leding, Paul Bruinenberg, Almari Conradie, Jerry Nedelman, Antonio Lombardi, Dean Hickman, Ulrika S. H. Simonsson   +6 more
wiley   +1 more source

Remission spectroscopy resolves the mechanism of action of bedaquiline within living mycobacteria

Nature Communications
Bedaquiline, an ATP synthase inhibitor, is the spearhead of transformative therapies against drug-resistant Mycobacterium tuberculosis. Here, we use remission spectroscopy to measure the energy-transducing cytochromes within unperturbed, respiring ...
Suzanna H. Harrison, Rowan C. Walters, Chen-Yi Cheung, Roger J. Springett, Gregory M. Cook, Morwan M. Osman, James N. Blaza   +6 more
doaj   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 964-978, April 2026.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Efficacy of Long-Acting Bedaquiline Regimens in a Mouse Model of Tuberculosis Preventive Therapy

, 2022
Rationale: Completion of preventive therapy is a major bottleneck in global tuberculosis control. Long-acting injectable drug formulations would shorten therapy administration and may thereby improve completion rates.
Nuermberger, Eric, Kaushik, Amit, Tasneen, Rokeya, Andries, Koen, Lachau-Durand, Sophie, Ammerman, Nicole C.   +5 more
core   +1 more source

A 9‐Year‐Old Boy With Right‐Sided Extrapulmonary Drug‐Resistant Tuberculosis Subphrenic Abscess: A Case Report From Woldia, Northeast Ethiopia

Clinical Case Reports, Volume 14, Issue 3, March 2026.
Coronal reconstruction post contrast thoraco‐abdominal CT of a 9 years old boy taken December, 2023. This shows 1.45 by 3.9 cms hypodense collection having rim enhancement in the right anterio‐inferior sub‐phrenic space suggestive of abscess. ABSTRACT Diagnosing extrapulmonary and drug‐resistant tuberculosis in children is challenging.
Animaw Lingerew, Samuel Addis, Adugnaw Atnafu, Zeru Siyoum, Solomie Jebessa Deribessa   +4 more
wiley   +1 more source