Results 81 to 90 of about 28,367 (198)

Optimized Loading Dose Strategies for Bedaquiline When Restarting Interrupted Drug-Resistant Tuberculosis Treatment

, 2022
Interruption of treatment is common in drug-resistant tuberculosis patients. Bedaquiline has a long terminal half-life; therefore, restarting after an interruption without a loading dose could increase the risk of suboptimal treatment outcome and ...
Maartens, Gary, Brust, James C. M.,, Koele, Simon E.,, van Beek, Stijn W.,, Svensson, Elin,, Maartens, Gary,, van Beek, Stijn W., Brust, James C. M., Svensson, Elin M., Koele, Simon E.   +9 more
core   +1 more source

Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline

, 2014
BACKGROUND Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred background ...
Meyvisch, Paul, de Los Rios, Jorge M., Grobusch, Martin P., Dannemann, Brian, Gotuzzo, Eduardo, Haxaire-Theeuwes, Myriam, Andries, Koen, Bakare, Nyasha, Diacon, Andreas H., de Paepe, Els, Pym, Alexander, Leimane, Vaira, van Heeswijk, Rolf P. G., Vasilyeva, Irina, de Marez, Tine, Lounis, Nacer   +15 more
core   +1 more source

Efektivitas Dan Keamanan Terapi dengan Rejimen Bedaquiline dalam Terapi Multidrug-Resistant Tuberculosis (TB-MDR): Kajian Sistematis [PDF]

, 2022
TB-MDR merupakan penyakit tuberculosis yang disebabkan oleh Mycobacterium tuberculosis yang sudah resistansi terhadap isoniazid dan rifampisin dengan atau tanpa resistansi terhadap obat lini pertama lainnya.
Yana, I Gusti Agung Ari Kusuma, Herawati, Fauna   +1 more
core  

A Novel PCD Phenotype: Inherent Mucus Hypersecretion by Patient‐Derived Airway Epithelial Cells

Pediatric Pulmonology, Volume 61, Issue 5, May 2026.
Joseph Castlen, Misael Leon, Sarah Wright, Benjamin Gaston, Laura Smith, Michael D. Davis, Allison Norlander, Andrew Tilston‐Lunel   +7 more
wiley   +1 more source

Drug-drug interactions between antiretrovirals and bedaquiline

, 2017
Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide. People living with HIV are particularly susceptible to TB infection, and treatment of HIV-TB co-infection is challenging for multiple reasons, including potential drug ...
Pandie, Mishal
core  

Cardiac toxicity of fluoroquinolones and bedaquiline

, 2019
The review analyzes data on the impact of fluoroquinolones and bedaquiline on the cardiac conduction system. The dependence of the cardiotoxic effect of fluoroquinolones on their influence on the potassium channels of cardiomyocytes is presented.
A. G. Sаmoylovа, G. N. Mozhokinа
core   +1 more source

Inhalable Dry Powder of Bedaquiline for Pulmonary Tuberculosis: In Vitro Physicochemical Characterization, Antimicrobial Activity and Safety Studies

Pharmaceutics, 2019
Bedaquiline is a newly developed anti-tuberculosis drug, conditionally approved by the United States Food and Drug Administration (USFDA) for treating drug-resistant tuberculosis in adults.
Mohammad A. M. Momin, Bhamini Rangnekar, Shubhra Sinha, Chen-Yi Cheung, Gregory M. Cook, Shyamal C. Das   +5 more
doaj   +1 more source

Effectiveness and safety of regimen containing bedaquiline and delamanid in patients with drug-resistant tuberculosis

Perspectives in Clinical Research
Background: Bedaquiline and delamanid have been included in the individualized treatment regimen (ITR) to treat patients with drug-resistant tuberculosis (DR-TB).
Oki Nugraha Putra, Yulistiani Yulistiani, Soedarsono Soedarsono, Susi Subay   +3 more
doaj   +1 more source

Linking genetic and phenotypic bedaquiline resistance in Mycobacterium tuberculosis strains from Georgia.

PLoS ONE
IntroductionResistance to bedaquiline - a novel, promising medication against tuberculosis (TB), is already emerging, and uncertainties regarding the role of the different resistance-conferring mutations complicate the development of molecular diagnostic
Nino Maghradze, Chloé Loiseau, Galo Adrian Goig, Nino Bablishvili, Levan Jugheli, Sonia Borrell, Nestani Tukvadze, Russell Ryan Kempker, Zaza Avaliani, Sebastien Gagneux   +9 more
doaj   +1 more source

Improvement in Outcomes with a New Bedaquiline-based Regimen in Postoperative Cases of Drug-resistant Tuberculosis of the Spine: A Case Series [PDF]

Journal of Clinical and Diagnostic Research
The incidence of drug-resistant strains of Tuberculosis (TB) is rising at an alarming rate. With the emergence of newer drug-resistant strains, managing the disease with existing antitubercular agents is becoming increasingly difficult. Few studies exist
Soutrik Kundu, Sarvan Singh
doaj   +1 more source