Results 121 to 130 of about 33,833 (238)

Online service for interpretation of the resistance prediction results to bedaquiline by the molecular data

Acta Biomedica Scientifica
Background. Bedaquiline is a new and promising anti-tuberculosis drug, but longterm use requires resistance. This is due to mutations in the atpE and mmpR genes in M.
V. V. Sinkov, I. G. Kondratov, O. B. Ogarkov, S. N. Zhdanova, A. P. Noskov, P. A. Khromova, E. A. Orlova, A. V. Labygina, L. V. Rychkova, L. I. Kolesnikova   +9 more
doaj   +1 more source

Bedaquiline Resistance and Molecular Characterization of Rifampicin-Resistant Mycobacterium Tuberculosis Isolates in Zhejiang, China

Infection and Drug Resistance, 2023
Enyu Tong,1,* Ying Zhou,1,* Zhengwei Liu,2 Yelei Zhu,2 Mingwu Zhang,2 Kunyang Wu,2 Junhang Pan,2 Jianmin Jiang1– 3 1School of Public Health, Hangzhou Normal University, Hangzhou, 311100, People’s Republic of China; 2Tuberculosis Control ...
Tong E, Zhou Y, Liu Z, Zhu Y, Zhang M, Wu K, Pan J, Jiang J   +7 more
doaj  

Delamanid and bedaquiline resistance patterns in Mycobacterium tuberculosis in Iran: A cross-sectional analysis

new microbes and new infections
Introduction The surge of multidrug-resistant TB (MDR-TB) in Iran poses a significant challenge to global healthcare. The introduction of delamanid (DLM) and bedaquiline (BDQ), two potent antimycobacterial drugs, marks a crucial advance. Nevertheless, as
AmirHossein Akbari Aghababa, M. Nasiri, P. Pakzad, E. Mirsamadi   +3 more
semanticscholar   +1 more source

Treatment of Tuberculous Meningitis and Its Complications in Adults. [PDF]

, 2017
PURPOSE OF REVIEW: Tuberculous meningitis (TBM) is a global health problem. In this review, we systematically evaluate the evidence for current and emerging antimicrobials, host-directed therapies and supportive managements.
Davis, A, Meintjes, G, Wilkinson, RJ
core   +1 more source

High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types. [PDF]

, 2018
Understanding the distribution patterns of antibiotics at the site of infection is paramount to selecting adequate drug regimens and developing new antibiotics.
Blanc, Landry, Chen, Pei-Yu, Dartois, Véronique, Daudelin, Isaac B, Martinot, Amanda J, Podell, Brendan K, Prideaux, Brendan, Savic, Rada M, Zimmerman, Matthew   +8 more
core   +2 more sources

Safety, pharmacokinetics, and early bactericidal activity of quabodepistat in combination with delamanid, bedaquiline, or both in adults with pulmonary tuberculosis: a randomised, active-controlled, open-label trial

Lancet. Infectious Diseases (Print)
Summary Background Quabodepistat (formerly OPC-167832) showed potent activity in preclinical studies and in the first stage of an early bactericidal activity study in adults with smear-positive, drug-susceptible pulmonary tuberculosis.
R. Dawson, A. Diacon, V. D. de Jager, K. Narunsky, V. M. Moodley, K. Stinson, Yongge Liu, Bo Zheng, J. Hafkin   +8 more
semanticscholar   +1 more source

Quabodepistat in combination with delamanid and bedaquiline in participants with drug-susceptible pulmonary tuberculosis: protocol for a multicenter, phase 2b/c, open-label, randomized, dose-finding trial to evaluate safety and efficacy

Trials
Background Delamanid and bedaquiline are two of the most recently developed antituberculosis (TB) drugs that have been extensively studied in patients with multidrug-resistant TB.
R. Dawson, A. Diacon, Simbarashe Takuva, Yongge Liu, Bo Zheng, Vatsala Karwe, J. Hafkin   +6 more
semanticscholar   +1 more source

Neoteric advancement in TB drugs and an overview on the anti-tubercular role of peptides through computational approaches [PDF]

, 2017
Peptides of varied origins such as human immune cells and non-immune cells, bacteria, fungi, and venoms have been widely investigated as anti-tubercular agents for the replacement of existing anti-tubercular drugs in future.
Aarti, Chirom, Aarti, Chirom, BARBABOSA PLIEGO, ALBERTO, BARBABOSA PLIEGO, ALBERTO, KHUSRO, AMEER, KHUSRO, AMEER, Zeidan Mohamed Salem, Abdelfattah, Zeidan Mohamed Salem, Abdelfattah   +7 more
core  

The exceptions that prove the rule—a historical view of bedaquiline susceptibility

Genome Medicine
In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis ...
P. Miotto, D. Cirillo, Thomas Schön, C. Köser   +3 more
semanticscholar   +1 more source

Major differences in organization and availability of health care and medicines for HIV/TB coinfected patients across Europe

, 2015
Objectives The aim of the study was to investigate the organization and delivery of HIV and tuberculosis (TB) health care and to analyse potential differences between treatment centres in Eastern (EE) and Western Europe (WE).
A Grzeszczuk, A Matteelli, A Mocroft, A Schultze, A Skrahina, AM Panteleev, AMW Efsen, DN Podlekareva, FA Post, H Furrer, I Zeltina, JD Lundgren, JM Miro, L Shepherd, M Mansfeld, N Bolokadze, null null, O Kirk, RF Miller, S Tetradov   +19 more
core   +1 more source