Results 31 to 40 of about 33,833 (238)

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. [PDF]

, 2017
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia.
Atre, Sachin R, Chang, Kwok Chiu, Churchyard, Gavin J, Clark, Taane G, Dheda, Keertan, Dooley, Kelly E, Dowdy, David, Esmail, Aliasgar, Fennelly, Kevin P, Furin, Jennifer, Goemaere, Eric, Gumbo, Tawanda, Hesseling, Anneke C, Horsburgh, C Robert, Jara, Carolina Morán, Jaramillo, Ernesto, Lange, Christoph, Lessem, Erica, Lin, Hsien-Ho, London, Leslie, Low, Marcus, Maartens, Gary, McIlleron, Helen, McNerney, Ruth, Menzies, Dick, Merker, Matthias, Murray, Megan, Nahid, Payam, Nardell, Edward A, Niemann, Stefan, Nuermberger, Eric, Padayatchi, Nesri, Pasipanodya, Jotam G, Rodrigues, Camilla, Schaaf, H Simon, Sirgel, Frik A, Siu, Gilman KH, Theron, Grant, Udwadia, Zarir F, van Helden, Paul, Van Rie, Annelies, Warren, Robin M   +41 more
core   +1 more source

Use of bedaquiline in spinal osteomyelitis and soft tissue abscess caused by multidrug-resistant Mycobacterium tuberculosis: A case report

Brazilian Journal of Infectious Diseases, 2022
Introduction: Spinal Tuberculosis (STB) represents between 1% and 2% of total tuberculosis cases. STB management remains challenging; the first-line approach consists of medical treatment, while surgery is reserved for patients with complications.
Andrea De Vito, Vito Fiore, Valentina Urru, Elena Bozzi, Nicholas Geremia, Elija Princic, Donatella Canu, Paola Molicotti, Riccardo Are, Sergio Babudieri, Giordano Madeddu   +10 more
doaj   +1 more source

Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study. [PDF]

, 2017
BACKGROUND: The emergence of programmatically incurable tuberculosis threatens to destabilise control efforts. The aim of this study was to collect prospective patient-level data to inform treatment and containment strategies.
Abdallah, Abdallah M, Ben-Rached, Fathia, Clark, Taane G, Dheda, Keertan, Dolby, Tania, Esmail, Aliasgar, Fennelly, Kevin P, Gumbo, Tawanda, Lesosky, Maia, Limberis, Jason D, Mastrapa, Barbara, McNerney, Ruth, Pain, Arnab, Phelan, Jody, Pietersen, Elize, Simpson, John, Sirgel, Frederick A, Smith, Liezel, Streicher, Elizabeth M, Te Riele, Julian, Theron, Grant, van Helden, Paul, Warren, Robin M   +22 more
core   +1 more source

Adverse drug reactions in South African patients receiving bedaquiline-containing tuberculosis treatment: an evaluation of spontaneously reported cases

BMC Infectious Diseases, 2019
Background Bedaquiline was recently introduced into World Health Organization (WHO)-recommended regimens for treatment of drug resistant tuberculosis. There is limited data on the long-term safety of bedaquiline.
Jackie Jones, Vanessa Mudaly, Jacqueline Voget, Tracey Naledi, Gary Maartens, Karen Cohen   +5 more
doaj   +1 more source

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles [PDF]

, 2018
Replacing the naphthalene C-unit of the anti-tuberculosis drug bedaquiline with a range of bicyclic heterocycles of widely differing lipophilicity gave analogs with a 4.5-fold range in clogP values.
Blaser, A, Choi, PJ, Conole, D, Cooper, CB, Denny, WA, Franzblau, SG, Lotlikar, MU, Palmer, BD, Sutherland, HS, Tong, AST, Upton, AM   +10 more
core   +1 more source

A Bayesian approach to estimate the probability of resistance to bedaquiline in the presence of a genomic variant.

PLoS ONE, 2023
BackgroundBedaquiline is a core drug for treatment of rifampicin-resistant tuberculosis. Few genomic variants have been statistically associated with bedaquiline resistance.
Degefaye Zelalem Anlay, Emmanuel Rivière, Pham Hien Trang Tu, Steven Abrams, Annelies Van Rie   +4 more
doaj   +1 more source

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]

, 2013
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
A Hill, A Koul, AE Grzegorzewicz, Alfonso Mendoza-Losana, Anil Kumar Tyagi, C Dye, C Varela, Carlos Alemparte, Carolina González, Chrystala Constantinidou, CK Stover, David Barros, David J. Dow, DJ Payne, Douglas J. Minick, Elena Jiménez, Esther Pérez-Herrán, Fátima Ortega-Muro, Gurdyal S. Besra, Iñigo Angulo-Barturen, JA Maddry, Joaquín Rullás, Johnson Afari, Jorge Esquivias, K Andries, K Pethe, K Tahlan, LL Ballell, Lluís Ballell, M Berry, M Biava, M Murray, M Protopopova, Mark J. Pallen, María José Rebollo-López, María Martínez-Hoyos, María Teresa Fraile-Gabaldón, Modesto J. Remuiñán, Mónica Cacho, Nalini Mehta, Nicholas Cammack, Nicholas J. Loman, R Singh, SA Stanley, ST Cole, V La Rosa, V Makarov, Verónica Sousa, Vickey L. Spivey   +48 more
core   +3 more sources

Genetic variants and their association with phenotypic resistance to bedaquiline in Mycobacterium tuberculosis: a systematic review and individual isolate data analysis

The Lancet Microbe, 2021
Summary: Background: Bedaquiline is a crucial drug for control of rifampicin-resistant tuberculosis. Molecular drug resistance assays could facilitate effective use of bedaquiline and surveillance of drug resistance emergence.
Nabila Ismail, PhD, Emmanuel Rivière, MSc, Jason Limberis, PhD, Stella Huo, MSc, John Z Metcalfe, ProfPhD, Rob M Warren, ProfPhD, Annelies Van Rie, ProfPhD   +6 more
doaj   +1 more source

The cursed duet today: Tuberculosis and HIV-coinfection [PDF]

, 2017
The tuberculosis (TB) and HIV syndemic continues to rage and are a major public health concern worldwide. This deadly association raises complexity and represent a significant barrier towards TB elimination.
Carvalho, ACC, Matin, N, Mello, FCDQ, Pontali, E, Rahman, A, Rendon, A, Sulis, G, Tiberi, S, Vaghela, D, Zumla, A   +9 more
core   +1 more source

Bedaquiline in the treatment of extensively drugresistant tuberculosis

Медицинский совет, 2022
Introduction. Extensive drug resistance (XDR) M. Tuberculosis (MBT) is considered the main factor that reduces the effectiveness of the treatment of TB patients around the world, including Russia.
T. I. Morozova, N. P. Doktorova, O. N. Otpushchennikova, N. Yu. Nikolenko   +3 more
doaj   +1 more source