Results 41 to 50 of about 29,860 (191)

Bedaquiline- versus injectable-containing drug-resistant tuberculosis regimens: a cost-effectiveness analysis

, 2018
Background: Drug-resistant tuberculosis (DR-TB) continues to be a major public health challenge with suboptimal treatment outcomes including well-documented treatment-related toxicities.
Adrian Thomas (5678363), Ana-Maria Ionescu (5678351), Abeda Williams (5678360), Chrispin Kambili (707561), Jonathan Kfoury (5678357), Abela Mpobela Agnarson (102684), Steven Wang (354193), Vikram Singh (757917), Laurent Metz (5678354)   +8 more
core   +1 more source

Baseline and acquired resistance to bedaquiline, linezolid and pretomanid, and impact on treatment outcomes in four tuberculosis clinical trials containing pretomanid.

PLOS Global Public Health, 2023
Bedaquiline (B), pretomanid (Pa) and linezolid (L) are key components of new regimens for treating rifampicin-resistant tuberculosis (TB). However, there is limited information on the global prevalence of resistance to these drugs and the impact of ...
Juliano Timm, Anna Bateson, Priya Solanki, Ana Paleckyte, Adam A Witney, Sylvia A D Rofael, Stella Fabiane, Morounfolu Olugbosi, Timothy D McHugh, Eugene Sun   +9 more
doaj   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Bedaquiline [PDF]

British Journal of Clinical Pharmacology, 2015
Sebastiaan C. Goulooze, Adam F. Cohen, Robert Rissmann   +2 more
  +6 more sources

Efektivitas Dan Keamanan Terapi dengan Rejimen Bedaquiline dalam Terapi Multidrug-Resistant Tuberculosis (TB-MDR): Kajian Sistematis [PDF]

, 2022
TB-MDR merupakan penyakit tuberculosis yang disebabkan oleh Mycobacterium tuberculosis yang sudah resistansi terhadap isoniazid dan rifampisin dengan atau tanpa resistansi terhadap obat lini pertama lainnya.
Yana, I Gusti Agung Ari Kusuma, Herawati, Fauna   +1 more
core   +2 more sources

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, Volume 15, Issue 34, 11 September 2026.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Stereodivergent Synthesis of C5‐α‐Substituted Linezolid Derivatives From D‐Mannitol and Structure–Antibacterial Activity Evaluation

Chirality, Volume 38, Issue 9, September 2026.
A stereodivergent route from D‐mannitol enables access to enantiopure C5‐α‐substituted linezolid analogues with full configurational control. Biological evaluation reveals that α‐substitution abolishes antibacterial activity irrespective of stereochemistry, establishing a strict steric limitation at C5 and highlighting the dominant role of substituent ...
José A. Gálvez, Laura Sanz‐Asensio, Ramón Badorrey, Jesús Gonzalo‐Asensio   +3 more
wiley   +1 more source

The Use of Bedaquiline in Children from Foci of Drug-Resistant Tuberculosis Infection

Антибиотики и Химиотерапия
Relevance. The increase in the incidence of drug-resistant tuberculosis necessitates the use of new etiotropic drugs. One of such contemporary drugs is bedaquiline.
T. S. Egorova, N. V. Rubleva, N. M. Bryntseva, Yu. A. Zhilyaeva, S. N. Novikova, Yu. I. Lebedev   +5 more
doaj   +1 more source