Results 31 to 40 of about 28,367 (198)
Bedaquiline-associated parameter ranges.
, 2016 Bedaquiline-associated parameter ranges.
Frank G. Cobelens (629970) +2 more
core +1 more source
In vitro activity of bedaquiline against slow-growing nontuberculous mycobacteria.
, 2019 <p>Bedaquiline (BDQ) is a recently approved antibiotic for the treatment of multidrug-resistant tuberculosis, but its potential against slow-growing mycobacteria (SGM) is still unknown.
A. Martin +11 more
core +1 more source
The Lancet Microbe, 2021 Summary: Background: Bedaquiline is a crucial drug for control of rifampicin-resistant tuberculosis. Molecular drug resistance assays could facilitate effective use of bedaquiline and surveillance of drug resistance emergence.
Nabila Ismail, PhD +6 more
doaj +1 more source
Bedaquiline in the treatment of extensively drugresistant tuberculosis
Медицинский совет, 2022 Introduction. Extensive drug resistance (XDR) M. Tuberculosis (MBT) is considered the main factor that reduces the effectiveness of the treatment of TB patients around the world, including Russia.
T. I. Morozova +3 more
doaj +1 more source
, 2018 Background: Drug-resistant tuberculosis (DR-TB) continues to be a major public health challenge with suboptimal treatment outcomes including well-documented treatment-related toxicities.
Adrian Thomas (5678363) +8 more
core +1 more source
PLOS Global Public Health, 2023 Bedaquiline (B), pretomanid (Pa) and linezolid (L) are key components of new regimens for treating rifampicin-resistant tuberculosis (TB). However, there is limited information on the global prevalence of resistance to these drugs and the impact of ...
Juliano Timm +9 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell +13 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer +24 more
wiley +1 more source
Bedaquiline and clofazimine : successes and challenges [PDF]
, 2020 Bedaquiline, a novel therapeutic drug, and clofazimine, a re-purposed drug, are front-line therapies recommended by WHO to treat rifampicin-resistant or multidrugresistant tuberculosis.
Ndjeka, Norbert, Ismail, Nazir Ahmed
core +1 more source