Results 41 to 50 of about 33,833 (238)
Maleate salts of bedaquiline [PDF]
Acta Crystallographica Section E Crystallographic Communications, 2021 Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). It is marketed in the US as its fumarate salt, but only a few salts of bedaquiline have been structurally described so far. We present here five crystal structures of bedaquilinium maleate {systematic name: [4-(6-bromo-2-methoxyquinolin-3-yl)-3-hydroxy ...
Matthias Zeller +7 more
openaire +3 more sources
Reply to Comments by Kakkar and Dahiya [PDF]
, 2014 TO THE EDITOR: Chahine, Karaoui, and Mansour1 reviewed the efficacy and safety of bedaquiline in the treatment of adults with pulmonary multidrug-resistant tuberculosis (MDR-TB) and generally agree with the comments made by Kakkar and Dahiya.2 ...
Chahine, Elias B. +2 more
core +1 more source
Synthesis, anti-tuberculosis activity and QSAR study of 2,4-diarylquinolines and analogous polycyclic derivatives [PDF]
, 2019 The multicomponent syntheses of 2,4-di-aryl-quinolines and analogous polycyclic derivatives as anti-tuberculosis agents were described. They were prepared via Beyer and Friedländer methods under microwave irradiation in short reaction times and good ...
Asís, Silvia Elizabeth +7 more
core +1 more source
Inhibitory effect of carvedilol on bedaquiline metabolism in vitro and in vivo [PDF]
PeerJBedaquiline has recently been approved for the treatment of multidrug-resistant tuberculosis. Carvedilol is a cardiovascular medication extensively used in the treatment of heart failure and hypertension.
Qingqing Li +4 more
doaj +2 more sources
BMC Infectious DiseasesDrug-resistant tuberculosis (TB) remains a major global public health challenge. While bedaquiline (BDQ) offers improved treatment outcomes for patients with multi-drug resistant TB (MDR-TB), its widespread use has led to the emergence of BDQ resistance.
Xinyang Hu +4 more
semanticscholar +1 more source
The role of delamanid in the treatment of drug-resistant tuberculosis [PDF]
, 2015 Tuberculosis (TB) remains a significant cause of death worldwide, and emergence of drug-resistant TB requires lengthy treatments with toxic drugs that are less effective than their first-line equivalents. New treatments are urgently needed.
Lewis, Joseph M., Sloan, Derek James
core +4 more sources
The Lancet Microbe, 2023 Summary Background Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis; however, the understanding of resistance mechanisms is poor, which is hampering rapid molecular diagnostics.
Lindsay Sonnenkalb +127 more
semanticscholar +1 more source
Management of multidrug-resistant TB : novel treatments and their expansion to low resource settings [PDF]
, 2016 This article received no specific funding. JL is supported by the Wellcome Trust as a clinical PhD fellow [grant number 109105/Z/15/Z].Despite overall progress in global TB control, the rising burden ofmultidrug-resistant TB (MDR-TB) threatens to ...
Lewis, Joseph M., Sloan, Derek James
core +2 more sources
Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers
Advanced Science, EarlyView.MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao +7 more
wiley +1 more source