Results 51 to 60 of about 284,523 (282)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Common myths in the behavioral addiction field [PDF]

, 2018
There is no shortage of controversy and debates within the field of behavioral addiction. In this paper, five myths are outlined concerning various behavioral addictions.
Griffiths, MD
core  

Buprenorphine added on brief cognitive behavioral therapy for treatment of methamphetamine use disorder [PDF]

, 2018
Background: Methamphetamine (MA) use remains a major public health concern around the world. Recent findings suggest that buprenorphine may be helpful for cocaine use reduction. Moreover, animal studies described reduced dopamine peak effect following MA
Dean AJ, Hassani-Abharian P, Hollister LE, Karimlou M, Kirchmayer U, Kosten TR, Mello NK, Nejati V, Raistrick D, Rothenberg JL,     +10 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A Theory of Natural Addiction [PDF]

Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Attila Tasnádi, Trenton G. Smith
core   +3 more sources

An exploratory study on internet addiction, somatic symptoms and emotional and behavioral functioning in school-aged adolescents [PDF]

, 2017
Objective: In the last two decades there has been a significant transformation regarding the use of new technologies. Despite growing acknowledgement concerning the different activities and functions of digital technologies, there remains a lack of ...
Cerutti, R., Fontana, A., Guidetti, V., Presaghi, F., Spensieri, V., Valastro, C.   +5 more
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Introduction to Behavioral Addictions [PDF]

The American Journal of Drug and Alcohol Abuse, 2010
Several behaviors, besides psychoactive substance ingestion, produce short-term reward that may engender persistent behavior, despite knowledge of adverse consequences, i.e., diminished control over the behavior. These disorders have historically been conceptualized in several ways. One view posits these disorders as lying along an impulsive-compulsive
Jon E, Grant, Marc N, Potenza, Aviv, Weinstein, David A, Gorelick   +3 more
openaire   +2 more sources

“I’ve learned that I’m open-minded to this possibility”: A qualitative study to evaluate the acceptability of a psilocybin-aided smoking cessation treatment for people with HIV who smoke

Addiction Science & Clinical Practice
Background People with HIV (PWH) are disproportionately affected by cigarette use, with a 40 − 70% prevalence rate. Although many express a strong interest in quitting, many PWH who smoke experience lower cessation rates with traditional treatments, in ...
Patricia A. Cioe, Garrett S. Stang, Danish Azam, Sarah Dugal   +3 more
doaj   +1 more source

Sex differences in behavioral dyscontrol: Role in drug addiction and novel treatments

Frontiers in Psychiatry, 2016
The purpose of this review is to discuss recent findings related to sex differences in behavioral dyscontrol that lead to drug addiction, and clinical implications for humans are discussed.
Marilyn E. Carroll, John R. Smethells
doaj   +1 more source