Results 51 to 60 of about 103,401 (257)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Experiences of Mothers of High School Students Regarding Virtual Education during COVID-19 [PDF]

مجله دانشگاه علوم پزشکی خراسان شمالی
Introduction: Virtual education during the COVID-19 pandemic brought about extensive changes in the education and life of students and their families. Therefore, it is important to identify various experiences of E-learning to understand the problems and
Hamid Tavakoli Ghouchani, Mohammad Khorrami, Faezeh Kaviyani, Dordane Asghari   +3 more
doaj  

Designing and Testing the Structural Model of Addiction to Online Games Based on Brain-behavioral Systems and Metacognitive Beliefs [PDF]

پژوهان, 2023
Background and Objectives: Addiction to online games negatively affects the physical and mental health of adolescents. The present study was conducted to investigate the mediating role of metacognitive beliefs in the relationship between behavioral brain
mohammad herangza, nader hajloo, mohammad narimani, sajjad basharpoor   +3 more
doaj  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Neglecting Long-Term Risks: Self-Disclosure on Social Media and Its Relation to Individual Decision-Making Tendencies and Problematic Social-Networks-Use

Frontiers in Psychology, 2020
Social media including social-networking sites (SNS) encourage people to disclose personal information via profiles and posts. It is assumed that positive short-term effects and immediate feedback (e.g., getting Likes) have a rewarding nature and may ...
Sina Ostendorf, Silke M. Müller, Matthias Brand, Matthias Brand   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Behavioral addictions and psychological distress: Insights from psychology students in Eastern Turkey

Humanities & Social Sciences Communications
The purpose of this study is to determine the prevalence of behavioral addictions in undergraduate psychology students and create a risk profile for behavioral addictions based on these variables.
Nilifer Gürbüzer, Derya Gürcan-Yıldırım   +1 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

How Financial Beliefs and Behaviors Influence the Financial Health of Individuals Struggling with Opioid Use Disorder

Behavioral Sciences
The surge in opioid use disorder (OUD) over the past decade escalated opioid overdoses to a leading cause of death in the United States. With adverse effects on cognition, risk-taking, and decision-making, OUD may negatively influence financial well ...
James R. Langabeer, Francine R. Vega, Marylou Cardenas-Turanzas, A. Sarah Cohen, Karima Lalani, Tiffany Champagne-Langabeer   +5 more
doaj   +1 more source