Results 61 to 70 of about 284,658 (331)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

“I’ve learned that I’m open-minded to this possibility”: A qualitative study to evaluate the acceptability of a psilocybin-aided smoking cessation treatment for people with HIV who smoke

Addiction Science & Clinical Practice
Background People with HIV (PWH) are disproportionately affected by cigarette use, with a 40 − 70% prevalence rate. Although many express a strong interest in quitting, many PWH who smoke experience lower cessation rates with traditional treatments, in ...
Patricia A. Cioe, Garrett S. Stang, Danish Azam, Sarah Dugal   +3 more
doaj   +1 more source

Sex differences in behavioral dyscontrol: Role in drug addiction and novel treatments

Frontiers in Psychiatry, 2016
The purpose of this review is to discuss recent findings related to sex differences in behavioral dyscontrol that lead to drug addiction, and clinical implications for humans are discussed.
Marilyn E. Carroll, John R. Smethells
doaj   +1 more source

Introduction to Behavioral Addictions [PDF]

The American Journal of Drug and Alcohol Abuse, 2010
Several behaviors, besides psychoactive substance ingestion, produce short-term reward that may engender persistent behavior, despite knowledge of adverse consequences, i.e., diminished control over the behavior. These disorders have historically been conceptualized in several ways. One view posits these disorders as lying along an impulsive-compulsive
Jon E, Grant, Marc N, Potenza, Aviv, Weinstein, David A, Gorelick   +3 more
openaire   +2 more sources

Bandit Models of Human Behavior: Reward Processing in Mental Disorders

, 2017
Drawing an inspiration from behavioral studies of human decision making, we propose here a general parametric framework for multi-armed bandit problem, which extends the standard Thompson Sampling approach to incorporate reward processing biases ...
A Dezfouli, AD Redish, AM Taylor, D Bouneffouf, D Bouneffouf, DC Perry, LE Hess, M Luman, MJ Frank, P Auer, P Auer, P Auer, TL Lai, TU Hauser, W Thompson, WR Thompson, WW Seeley   +16 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Designing and Testing the Structural Model of Addiction to Online Games Based on Brain-behavioral Systems and Metacognitive Beliefs [PDF]

پژوهان, 2023
Background and Objectives: Addiction to online games negatively affects the physical and mental health of adolescents. The present study was conducted to investigate the mediating role of metacognitive beliefs in the relationship between behavioral brain
mohammad herangza, nader hajloo, mohammad narimani, sajjad basharpoor   +3 more
doaj  

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

The Effect of Cognitive Behavior Therapy in Insomnia due to Methadone Maintenance Therapy: A Randomized Clinical Trial

Iranian Journal of Medical Sciences, 2015
Background: Sleep disturbance is a common complaint of patients undergoing methadone maintenance therapy (MMT). There are limited studies about the effect of different treatments on insomnia due to MMT. In this study, we evaluated the effect of cognitive-
Robabeh Soleimani, Mohammad Jafar Modabbernia, Sharareh Habibi, Maryam Habibi Roudsary, Masoumeh Elahi   +4 more
doaj  

Metacognition in addictive behaviors [PDF]

Addictive Behaviors, 2015
Over the last twenty years metacognitive theory has provided a novel framework, in the form of the Self-Regulatory Executive Function (S-REF) model, for conceptualizing psychological distress (Wells & Matthews, 1994, 1996). The S-REF model proposes that psychological distress persists because of unhelpful coping styles (e.g.
Spada, Marcantonio, Caselli, Gabriele, Nikcevic, Ana, Wells, Adrian   +3 more
openaire   +3 more sources