Results 31 to 40 of about 42,152 (307)

Rna M6a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis

Advanced Science, 2023
N6‐methyladenosine (m6A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood.
Yu Li, Yankang Zhang, Ting Zhang, Xiaodan Ping, Dongmei Wang, Yanru Chen, Jian Yu, Caizhi Liu, Ziqi Liu, Yuhan Zheng, Yongfeng Yang, Chengchao Ruan, Dali Li, Zhenyu Du, Jiqiu Wang, Lingyan Xu, Xinran Ma   +16 more
doaj   +1 more source

Becoming less beige with age

eLife, 2023
The production of beige adipocytes following cold exposure is blocked as mice get older and leads to changes in the expression of metabolic genes.
Anying Song, Qiong A Wang
openaire   +3 more sources

LONG-TERM AND MID-TERM MOBILITY DECISIONS DURING THE LIFE COURSE

IATSS Research, 2008
Long-term and mid-term mobility of people involves on the one hand decisions about their residential locations and the corresponding moves. At the same time, the places of education and employment play an important role.
Sigrun BEIGE
doaj   +1 more source

Early Rapid Decline in Kidney Function as a Beneficial Sign After Starting Antihypertensive Medication

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
See Article Cooper et ...
Joachim Beige
doaj   +1 more source

Engineering Human Beige Adipose Tissue

Frontiers in Bioengineering and Biotechnology, 2022
In this study, we described a method for generating functional, beige (thermogenic) adipose microtissues from human microvascular fragments (MVFs). The MVFs were isolated from adipose tissue acquired from adults over 50 years of age. The tissues express thermogenic gene markers and reproduce functions essential for the potential therapeutic impact of ...
Maria A. Gonzalez Porras, Maria A. Gonzalez Porras, Katerina Stojkova, Francisca M. Acosta, Christopher R. Rathbone, Christopher R. Rathbone, Eric M. Brey, Eric M. Brey   +7 more
openaire   +3 more sources

Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions

Journal of Tissue Engineering, 2022
Engineered beige adipose tissues could be used for screening therapeutic strategies or as a direct treatment for obesity and metabolic disease. Microvascular fragments are vessel structures that can be directly isolated from adipose tissue and may ...
Francisca M. Acosta, Katerina Stojkova, Jingruo Zhang, Eric Ivan Garcia Huitron, Jean X. Jiang, Christopher R. Rathbone, Eric M. Brey   +6 more
doaj   +1 more source

Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis. [PDF]

PLoS Pathogens, 2008
The intracellular protozoan Leishmania replicates in parasitophorous vacuoles (PV) that share many features with late endosomes/lysosomes. L. amazonensis PVs expand markedly during infections, but the impact of PV size on parasite intracellular survival ...
Jude Wilson, Chau Huynh, Kathleen A Kennedy, Diane M Ward, Jerry Kaplan, Alan Aderem, Norma W Andrews   +6 more
doaj   +1 more source

A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome

Cell Reports, 2018
Summary: Molecular- and cellular-based therapies have the potential to reduce obesity-associated disease. In response to cold, beige adipocytes form in subcutaneous white adipose tissue and convert energy stored in metabolic substrates to heat, making ...
Su Su, Anyonya R. Guntur, Daniel C. Nguyen, Shameem S. Fakory, Chad C. Doucette, Cassandra Leech, Humphrey Lotana, Matthew Kelley, Jaspreet Kohli, Julieta Martino, Sunder Sims-Lucas, Lucy Liaw, Calvin Vary, Clifford J. Rosen, Aaron C. Brown   +14 more
doaj   +1 more source

Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice

Nature Communications, 2023
Thermogenic beige fat can reduce fat mass and improve metabolic health, yet the ability to form beige fat rapidly declines with age. Here, the authors show that targeting the age-related ramping of Pdgfrβ signalling restores the ageing adipose tissue ...
Abigail M. Benvie, Derek Lee, Benjamin M. Steiner, Siwen Xue, Yuwei Jiang, Daniel C. Berry   +5 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source