Results 41 to 50 of about 42,152 (307)

Imaging adipose tissue browning using the TSPO-18kDa tracer [18F]FEPPA

Molecular Metabolism, 2019
Objectives: The browning of white adipose tissue (WAT) into beige has been proposed as a strategy to enhance energy expenditure to combat the growing epidemic of obesity.
S.V. Hartimath, S. Khanapur, R. Boominathan, L. Jiang, P. Cheng, F.F. Yong, P.W. Tan, E.G. Robins, J.L. Goggi   +8 more
doaj   +1 more source

A Method to Induce Brown/Beige Adipocyte Differentiation from Murine Preadipocytes

Bio-Protocol, 2021
Adipocytes exhibit different morphological and functional characteristics, depending on their anatomical location, developmental origin, and stimulus. While white adipocytes tend to accumulate energy as triglycerides, brown and beige adipocytes tend to ...
Andréa Rocha, Beatriz Guerra, Jeremie Boucher, Marcelo Mori   +3 more
doaj   +1 more source

3D‐Printed Porous Hydroxyapatite Formed via Enzymatic Mineralization

Advanced Functional Materials, EarlyView.
Bone combines lightness, strength, and the ability to heal, inspiring new materials design. This work introduces a room‐temperature, enzyme‐mediated 3D printing method to create porous hydroxyapatite scaffolds. The process avoids energy‐intensive sintering, preserves bioactivity, and allows control over porosity and mineralization.
Francesca Bono, Anna Puiggalí‐Jou, Greta Cocchi, Mariangela Miccoli, Katharina Maniura‐Weber, Marcy Zenobi‐Wong, Esther Amstad   +6 more
wiley   +1 more source

Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone

Biology, 2019
While it is now understood that the proper expansion of adipose tissue is critically important for metabolic homeostasis, it is also appreciated that adipose tissues perform far more functions than simply maintaining energy balance.
Kevin J. Phillips
doaj   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Dopaminergic Hyperactivity Accompanied by Hyperlocomotion in C57BL/6J-bgJ/bgJ (beige-J) Mice

Journal of Pharmacological Sciences, 2014
.: Genetic factors affect locomotor activity, which mainly depends on the activation of dopaminergic systems. C57BL/6J-bgJbgJ (beige-J) mice, which exhibit deficiencies in immunological function, show behavioral hyperactivity.
Tomohisa Mori, Masahiko Funada, Yuko Tsuda, Jun Maeda, Masashi Uchida, Tsutomu Suzuki   +5 more
doaj   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Participation of macrophages in atherosclerotic lesion morphology in LDLr−/− mice

Journal of Lipid Research, 2004
Lystbeige (beige) mice crossed with LDL receptor-deficient (LDLr−/−) mice had a distinct atherosclerotic lesion morphology that was not observed in LDLr−/− mice. This morphology is often associated with a stable plaque phenotype.
Natalie K. Schiller, Audrey S. Black, Gary P. Bradshaw, David J. Bonnet, Linda K. Curtiss   +4 more
doaj   +1 more source

Observation of Edge‐Confined Acoustic Hyperbolic Polaritons in van der Waals Materials

Advanced Science, EarlyView.
This work demonstrates a new type of light wave—edge‐confined acoustic hyperbolic polaritons—in hexagonal boron nitride on gold. These waves travel along crystal edges with nanoscale confinement and strongly interact with molecular vibrations, enabling highly sensitive detection of tiny molecular layers.
Tianning Zhang, Xiaojie Jiang, Xiaosheng Yang, Xinliang Zhang, Peining Li   +4 more
wiley   +1 more source