Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity. [PDF]
Theranostics, 2020 Xu Y +6 more
europepmc +2 more sources
Beige adipocytes contribute to breast cancer progression
Oncology Reports, 2020 Adipocytes are the main stromal cells in the mammary microenvironment, and crosstalk between adipocytes and breast cancer cells may play a critical and important role in cancer maintenance and progression. Tumor‑induced differentiation to beige/brown adipose tissue is an important contribution to the hypermetabolic state of breast cancer.
Mariana Gantov +6 more
openalex +6 more sources
The Beige Adipocyte as a Therapy for Metabolic Diseases. [PDF]
Int J Mol Sci, 2019 Adipose tissue is traditionally categorized into white and brown relating to their function and morphology. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue more energetically active, with a greater number of ...
Lizcano F.
europepmc +6 more sources
Towards a Better Understanding of Beige Adipocyte Plasticity. [PDF]
Cells, 2019 Beige adipocytes are defined as Ucp1+, multilocular adipocytes within white adipose tissue (WAT) that are capable of thermogenesis, the process of heat generation. In both mouse models and humans, the increase of beige adipocyte population, also called WAT browning, is associated with certain metabolic benefits, such as reduced obesity and increased ...
Paulo E, Wang B.
europepmc +4 more sources
TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis. [PDF]
Nat Commun, 2020 AbstractIt has been suggested that beige fat thermogenesis is tightly controlled by epigenetic regulators that sense environmental cues such as temperature. Here, we report that subcutaneous adipose expression of the DNA demethylase TET1 is suppressed by cold and other stimulators of beige adipocyte thermogenesis.
Damal Villivalam S +8 more
europepmc +7 more sources
Aquaglyceroporins Are Differentially Expressed in Beige and White Adipocytes [PDF]
International Journal of Molecular Sciences, 2020 Browning of white adipocytes has been proposed as a powerful strategy to overcome metabolic complications, since brown adipocytes are more catabolic, expending energy as a heat form. However, the biological pathways involved in the browning process are still unclear.
Anna Gumà +9 more
openaire +4 more sources
Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. [PDF]
PLoS Genetics, 2017 Given the relevance of beige adipocytes in adult humans, a better understanding of the molecular circuits involved in beige adipocyte biogenesis has provided new insight into human brown adipocyte biology. Genetic mutations in SLC39A13/ZIP13, a member of
Ayako Fukunaka +17 more
doaj +1 more source
Neonatal intake of Omega-3 fatty acids enhances lipid oxidation in adipocyte precursors
iScience, 2023 Summary: Establishing metabolic programming begins during fetal and postnatal development, and early-life lipid exposures play a critical role during neonatal adipogenesis. We define how neonatal consumption of a low omega-6 to −3 fatty acid ratio (n6/n3
Rohan Varshney +14 more
doaj +1 more source
Mitochondria in White, Brown, and Beige Adipocytes [PDF]
Stem Cells International, 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Vaclav Babuska +7 more
openaire +4 more sources
Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo [PDF]
, 2017 This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030000) and the CAS-Novonordisk Foundation, as well as grants from the ‘1000 talents’ recruitment program, and a ‘Great-wall professorship’ from ...
Jin, Wanzhu +8 more
core +10 more sources