Results 21 to 30 of about 11,954 (253)

Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes

Nature Communications, 2022
Thermogenic adipocytes maintain body temperature in response to cold, but how this is tuned during cold and re-warming is unclear. Here, the authors show HIF2α inhibits beige adipocyte retention, regulating PKA catalysis to control dynamic adipocyte ...
Ji Seul Han, Yong Geun Jeon, Minsik Oh, Gung Lee, Hahn Nahmgoong, Sang Mun Han, Jeehye Choi, Ye Young Kim, Kyung Cheul Shin, Jiwon Kim, Kyuri Jo, Sung Sik Choe, Eun Jung Park, Sun Kim, Jae Bum Kim   +14 more
doaj   +3 more sources

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function [PDF]

Nature Communications, 2016
Beige adipocytes are formed in response to cold and thought to contribute to organismal energy homeostasis. Here, the authors study a range of conditional and inducible RFP-expressing Cre mouse strains and find that SMA-based lines are the most useful ...
Daniel C. Berry, Yuwei Jiang, Jonathan M. Graff   +2 more
doaj   +3 more sources

Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity. [PDF]

Adv Sci (Weinh), 2023
Sun Y, Zhang J, Hong J, Zhang Z, Lu P, Gao A, Ni M, Zhang Z, Yang H, Shen J, Lu J, Xue W, Lv Q, Bi Y, Zeng YA, Gu W, Ning G, Wang W, Liu R, Wang J.   +19 more
europepmc   +3 more sources

Rutin Maintains the Thermogenic Phenotype of Beige Adipocytes and Concomitantly Suppresses Mitophagy Against Obesity in HFD Mice [PDF]

Metabolites
Background: The browning of white adipose tissue for thermogenesis is an effective strategy for combating obesity. The formation of beige adipocytes is reversible, making their maintenance a key therapeutic target.
Jianmei Li, Kexin Li, Shengnan Li, Jingxun Cui, Shuangying Zhou, Huiwen Wu   +5 more
doaj   +2 more sources

Lsd1 prevents age-programed loss of beige adipocytes [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Over time, beige adipocytes gain a white adipocyte morphology and lose their thermogenic activity. Here we show that levels of the epigenetic eraser lysine-specific demethylase 1 (Lsd1) decrease in aging inguinal white adipose tissue concomitantly with beige fat cell decline.
Delphine Duteil, Milica Tošić, Dominica Willmann, Anastasia Georgiadi, Toufike Kanouni, Roland Schüle   +5 more
openalex   +5 more sources

Mitochondrial RNA stimulates beige adipocyte development in young mice. [PDF]

Nat Metab, 2022
Abstract Childhood obesity is a serious public health crisis and a critical factor that determines future obesity prevalence. Signals affecting adipocyte development in early postnatal life have a strong potential to trigger childhood obesity; however, these signals are still poorly understood.
Hoang AC, Sasi-Szabó L, Pál T, Szabó T, Diedrich V, Herwig A, Landgraf K, Körner A, Röszer T.   +8 more
europepmc   +4 more sources

The essential role of architectural noncoding RNA <i>Neat1</i> in cold-induced beige adipocyte differentiation in mice. [PDF]

RNA
Toya H, Okamatsu-Ogura Y, Yokoi S, Kurihara M, Mito M, Iwasaki S, Hirose T, Nakagawa S.   +7 more
europepmc   +3 more sources

Functional and Genetic Characterization of Porcine Beige Adipocytes [PDF]

Cells, 2022
Beige adipocytes are a distinct type of fat cells with a thermogenic activity that have gained substantial attention as an alternative cellular anti-obesity target in humans. These cells may provide an alternative strategy for the genetic selection of pigs with reduced fat deposition.
Lilan Zhang, Silu Hu, Chunwei Cao, Chuanhe Chen, Jiali Liu, Yu Wang, Jianfeng Liu, Jianguo Zhao, Cong Tao, Yanfang Wang   +9 more
openaire   +3 more sources

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism. [PDF]

Sci Signal, 2018
Lu X, Altshuler-Keylin S, Wang Q, Chen Y, Henrique Sponton C, Ikeda K, Maretich P, Yoneshiro T, Kajimura S.   +8 more
europepmc   +3 more sources

Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. [PDF]

PLoS Genetics, 2017
Given the relevance of beige adipocytes in adult humans, a better understanding of the molecular circuits involved in beige adipocyte biogenesis has provided new insight into human brown adipocyte biology. Genetic mutations in SLC39A13/ZIP13, a member of
Ayako Fukunaka, Toshiyuki Fukada, Jinhyuk Bhin, Luka Suzuki, Takamasa Tsuzuki, Yuri Takamine, Bum-Ho Bin, Toshinori Yoshihara, Noriko Ichinoseki-Sekine, Hisashi Naito, Takeshi Miyatsuka, Shinzaburo Takamiya, Tsutomu Sasaki, Takeshi Inagaki, Tadahiro Kitamura, Shingo Kajimura, Hirotaka Watada, Yoshio Fujitani   +17 more
doaj   +1 more source