Results 31 to 40 of about 11,513 (248)

Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse. [PDF]

Cells, 2021
The present study sought to identify gene networks that are hallmarks of the developing inguinal subcutaneous adipose tissue (iWAT) and the interscapular brown adipose tissue (BAT) in the mouse. RNA profiling revealed that the iWAT of postnatal (P) day 6 mice expressed thermogenic and lipid catabolism transcripts, along with the abundance of ...
Hoang AC, Yu H, Röszer T.
europepmc   +5 more sources

Ceiling culture of human mature white adipocytes with a browning agent: A novel approach to induce transdifferentiation into beige adipocytes

Frontiers in Bioengineering and Biotechnology, 2022
Excess and dysfunctional adipose tissue plays an important role in metabolic diseases, including obesity, atherosclerosis and type 2 diabetes mellitus. In mammals, adipose tissue is categorized into two types: white and brown.
Yufei He, Zhuokai Liang, Jing Wang, Haojing Tang, Jian Li, Junrong Cai, Yunjun Liao   +6 more
doaj   +1 more source

A Smooth Muscle-Like Origin for Beige Adipocytes [PDF]

Cell Metabolism, 2014
Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal profiling approach, we present a comprehensive molecular description of brown and beige gene expression from multiple fat depots in vivo.
Wendy Baur, Xingxing Kong, Bruce M. Spiegelman, Jonathan Z. Long, John J. Castellot, Isha A. Lokurkar, Hyun Cheol Roh, Linus T.-Y. Tsai, Jesse Lou, Xing Zeng, Evan D. Rosen, Katrin J. Svensson, Rajesh R. Rao   +12 more
openaire   +3 more sources

CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation [PDF]

International Journal of Molecular Sciences, 2020
Brown adipose tissue (BAT) is a thermogenic organ in rodents and humans. In mice, the transplantation of BAT has been successfully used to combat obesity and its comorbidities. While such beneficial properties of BAT are now evident, the developmental and cellular origins of brown, beige, and white adipocytes have remained only poorly understood ...
Daniel Halbgebauer, Julia Zinngrebe, Pamela Fischer-Posovszky, Klaus-Michael Debatin, Jan-Bernd Funcke, Sophie Kiener, Julian Roos, Daniel Tews, Daniel Engel, Markus Rojewski, Thomas K. Hoffmann, J Döscher, Martin Wabitsch, Patrick J. Schuler, Meike Dahlhaus, Hubert Schrezenmeier, Hubert Schrezenmeier   +16 more
openaire   +3 more sources

An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling [PDF]

Nature Medicine, 2018
Heejin Jun, Jianke Gong, Eric Perkey
exaly   +2 more sources

A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. [PDF]

, 2016
Beige adipocytes emerge postnatally within the white adipose tissue in response to certain environmental cues, such as chronic cold exposure. Because of its highly recruitable nature and relevance to adult humans, beige adipocytes have gained much ...
Bannai, Makoto, Kajimura, Shingo, Nogusa, Yoshihito, Ohyama, Kana, Shinoda, Kosaku, Suzuki, Katsuya   +5 more
core   +2 more sources

Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]

, 2019
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski, AA Lans van der, Andrew Brack, Annarita Scaramozza, C Trapnell, Carlos Henrique Sponton, DC Berry, ES Bachman, H Ohno, J Nedergaard, J Sanchez-Gurmaches, J Wu, JR Arch, JZ Long, K Ikeda, K Nishijo, K Shinoda, Kazuki Tajima, Kenji Ikeda, Kosaku Shinoda, Kyeongkyu Kim, L Kazak, L Vishvanath, L Ye, LZ Sharp, M Razzoli, ME Lidell, MJ Hanssen, ML Gantner, MS Rodeheffer, P Cohen, P Seale, Qiang Wang, S Collins, S Heinz, S Jung, S Kajimura, S Tripathi, Shingo Kajimura, T Buch, T Yoneshiro, Takeshi Yoneshiro, VK Mootha, Y Hasegawa, YH Lee, YH Tseng, Yong Chen, Zachary Brown, ZF Yang   +48 more
core   +2 more sources

Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity. [PDF]

J Endocrinol, 2018
Numerous studies have suggested that beige adipocyte abundance is correlated with improved metabolic performance, but direct evidence showing that beige adipocyte expansion protects animals from the development of obesity is missing. Previously, we have described that the liver kinase b1 (LKB1) regulates beige adipocyte renaissance in subcutaneous ...
Paulo E, Wu D, Hecker P, Zhang Y, Wang B.   +4 more
europepmc   +7 more sources

UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes [PDF]

Frontiers in Endocrinology, 2020
Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to dissipates energy in the form of heat by uncoupling the mitochondrial proton gradient from mitochondrial respiration.
Tetsuya Yamada, Kenji Ikeda
openaire   +4 more sources

Irisin Reduces the Metabolic Rate of Beige Adipocytes [PDF]

The 9th Conference of Biochemistry and Physiology of Exercise, 2019
AIM: Irisin is released in the circulation in response to exercise and may increase energy expenditure by stimulating the browning of white adipose tissue through UCP1 upregulation. We aimed to investigate the effects of treatment with human recombinant irisin on the metabolic profile of 3T3-L1 differentiated beige adipocytes.
Maria Vliora, Elisabetta Grillo, Paraskevi Sakellariou, Stefania Mitola, Andreas D. Flouris   +4 more
openaire   +3 more sources