FTO Obesity Variant Circuitry and Adipocyte Browning in Humans [PDF]
, 2015 Background Genomewide association studies can be used to identify disease-relevant genomic regions, but interpretation of the data is challenging. The FTO region harbors the strongest genetic association with obesity, yet the mechanistic basis of this ...
Abdennur, Nezar Alexander +18 more
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Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]
, 2019 Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang +9 more
core
Cells, 2019 Induced brown adipocytes (also referred to as beige cells) execute thermogenesis, as do the classical adipocytes by consuming stored lipids, being related to metabolic homeostasis.
Ying-Chin Lin +3 more
doaj +1 more source
Comparative analysis of microRNA expression in mouse and human brown adipose tissue [PDF]
, 2015 BACKGROUND: In small mammals brown adipose tissue (BAT) plays a predominant role in regulating energy expenditure (EE) via adaptive thermogenesis. New-born babies require BAT to control their body temperature, however its relevance in adults has been ...
Crowley, Tamsyn +6 more
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Regulatory mechanism of white adipocyte browning and research advances [PDF]
BIO Web of ConferencesAdipose tissue has energy storage and metabolic functions, and its content is highly correlated with an individual’s obesity status. The relative proportions of white adipocytes, brown adipocytes, and beige adipocytes are also important in regulating ...
Wang Zihan
doaj +1 more source
Epigenetic regulation of beige adipocyte fate by histone methylation
Endocrine Journal, 2019 Adipose tissue harbors plasticity to adapt to environmental thermal changes. While brown adipocyte is a thermogenic cell which produces heat acutely in response to cold stimuli, beige (or brite) adipocyte is an inducible form of thermogenic adipocytes which emerges in the white adipose depots in response to chronic cold exposure.
Tomohiro Suzuki +5 more
openaire +4 more sources
TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging [PDF]
, 2019 Tonicity-responsive enhancer binding protein (TonEBP or NFAT5) is a regulator of cellular adaptation to hypertonicity, macrophage activation and T-cell development. Here we report that TonEBP is an epigenetic regulator of thermogenesis and obesity.
AM Cypess +48 more
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Dielectric properties measurements of brown and white adipose tissue in rats from 0.5 to 10 GHz [PDF]
, 2016 Brown adipose tissue (BAT) plays an important role in whole body metabolism and with appropriate stimulus could potentially mediate weight gain and insulin sensitivity.
Colebeck, E. +6 more
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Changing white into brite adipocytes. Focus on >BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells> [PDF]
, 2014 Editorial.This review was supported by Grants S2010/BMD-2423 from Comunidad de Madrid and SAF2012-32491 from MINECO (Ministerio de Economia y Competitividad), Spain (to M.-J.
Blaskovich, Mark A.T. +4 more
core +2 more sources
EBF2 promotes the recruitment of beige adipocytes in white adipose tissue
Molecular Metabolism, 2016 The induction of beige/brite adipose cells in white adipose tissue (WAT) is associated with protection against high fat diet-induced obesity and insulin resistance in animals. The helix-loop-helix transcription factor Early B-Cell Factor-2 (EBF2) regulates brown adipose tissue development.
Stine, Rachel R. +6 more
openaire +4 more sources