Results 91 to 100 of about 172,738 (259)

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Metabolic Reprogramming in Adipose Tissue During Cancer Cachexia

Frontiers in Oncology, 2022
Cancer cachexia is a disorder of energy balance characterized by the wasting of adipose tissue and skeletal muscle resulting in severe weight loss with profound influence on morbidity and mortality. Treatment options for cancer cachexia are still limited.
Bahar Zehra Camurdanoglu Weber, Dilsad H. Arabaci, Serkan Kir   +2 more
doaj   +1 more source

Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides) [PDF]

, 2021
Laura Niiranen, Kari A. Mäkelä, Shivaprakash Jagalur Mutt, Riikka Viitanen, Anna Kaisanlahti, David Vicente, Tommi Noponen, Anu Autio, Anne Roivainen, Pirjo Nuutila, Seppo Saarela, Karl‐Heinz Herzig   +11 more
openalex   +1 more source

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

Characterization of the central neural projections to brown, white, and beige adipose tissue

The FASEB Journal, 2017
The functional recruitment of classic brown adipose tissue (BAT) and inducible brown‐like or beige fat is, to a large extent, dependent on intact sympathetic neural input. Whereas the central neural circuits directed specifically to BAT or white adipose tissue (WAT) are well established, there is only a developing insight into the ...
Nicole M Wiedmann, A. Stefanidis, B. Oldfield   +2 more
semanticscholar   +3 more sources

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

Food Frontiers, EarlyView.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu, Haoyu Li, Youyou Zheng, Xiaoqian Chen, Xuzhi Wan, Pan Zhuang, Wei Jia, Jianxin Yao, Haoyin Liu, Hongbo Shi, Xunan Lin, Yu Zhang, Jingjing Jiao   +12 more
wiley   +1 more source

miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]

, 2020
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria, Laface, Ilaria, Milani, Daniela, Neri, Luca M, Rimondi, Erika, Simioni, Carolina, Varano, Gabriele   +6 more
core   +1 more source

Front Cover: Nicotinamide Protects Against Diet‐Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging [PDF]

, 2021
Karen Alejandra Méndez‐Lara, Elisabeth Rodríguez‐Millán, David Sebastián, Rosi Blanco‐Soto, Mercedes Camacho, Madalina N. Nan, Elena M. G. Diarte‐Añazco, Eugènia Mato, Silvia Lope–Piedrafita, Núria Roglans, Juan C. Laguna, Núria Alonso, Dı́dac Mauricio, António Zorzano, Francesc Villarroya, Josep A. Villena, Francisco Blanco‐Vaca, Josep Julve   +17 more
openalex   +1 more source

Dynamic contrast‐enhanced MRI of brown and beige adipose tissues

Magnetic Resonance in Medicine, 2019
PurposeThe vascular blood flow in brown adipose tissue (BAT) is important for handling triglyceride clearance, increased blood flow and oxygenation. We used dynamic contrast‐enhanced (DCE)‐MRI and fat fraction (FF) imaging for investigating vascular perfusion kinetics in brown and beige adipose tissues with cold exposure or treatment with β3‐adrenergic
Jadegoud Yaligar, Sanjay Kumar Verma, Venkatesh Gopalan, Rengaraj Anantharaj, Giang Thi Thu Le, Kavita Kaur, Karthik Mallilankaraman, Melvin Khee‐Shing Leow, S. Sendhil Velan   +8 more
openalex   +4 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source