Results 81 to 90 of about 9,335 (162)

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

Cell Reports, 2013
The phenomenon of white fat "browning," in which certain white adipose tissue depots significantly increase gene expression for the uncoupling protein UCP1 and thus supposedly acquire thermogenic, fat-burning properties, has attracted considerable attention.
Irina G. Shabalina, Natasa Petrovic, Jasper M.A. de Jong, Anastasia V. Kalinovich, Barbara Cannon, Jan Nedergaard   +5 more
openaire   +3 more sources

Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CCR1 expression is significantly elevated in adipose tissue of obese individuals. Systemic and adipocyte‐specific Ccr1 deletion promotes fat browning via cAMP/PKA/CREB activation and M2 macrophage polarisation, protecting against obesity. Pharmacological blockade of CCR1 suppresses obesity progression, highlighting its potential as a novel target for ...
Suili Cai, Mengchen Ma, Yuqin Zhu, Mengru Shi, Xiaoyan Dai, Yujie Wang, Mengru Li, Yanwen Yu, Yajiao Wang, Liang Xu   +9 more
wiley   +1 more source

Optical imaging for brown or beige adipose tissue

VIEW
AbstractCurrently, one in three adults worldwide may be obese or overweight. Obesity is characterized by an excess of energy‐storing white fat. An ingenious and sought‐after strategy against obesity is to activate energy‐consuming beige fat, which is converted from white fat or brown fat.
Jiamin Liu, Linjie Ni, Minmin Peng, Yiying Liang, Chan Lu, Hanying Zheng, Zicheng Huang, Jinde Zhang, Ronghe Chen   +8 more
openaire   +2 more sources

The Role of β3-Adrenergic Receptors in Cold-Induced Beige Adipocyte Production in Pigs

Cells
After exposure to cold stress, animals enhance the production of beige adipocytes and expedite thermogenesis, leading to improved metabolic health.
Shuo Yang, Hong Ma, Liang Wang, Fang Wang, Jiqiao Xia, Dongyu Liu, Linlin Mu, Xiuqin Yang, Di Liu   +8 more
doaj   +1 more source

Therapeutic Potential of Water‐Based Anatolian Propolis Extract Against CAF Diet‐Induced Obesity and Its Metabolic Complications

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Water‐based Anatolian propolis extract attenuates CAF diet‐induced obesity‐related metabolic disturbances by improving dyslipidemia, hepatic injury, adipokine imbalance, and inflammatory status in C57BL/6 mice. ABSTRACT This study investigates the anti‐obesity effects of water‐based Anatolian propolis extract in mice with a cafeteria diet‐induced ...
Mehmet Kemal, Elif Şahin, Ali Kulaber, Sevil Kör, Ahmet Alver, Engin Yenilmez, Sevgi Kolaylı   +6 more
wiley   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Human Islet miR‐199a‐5p and miR‐214‐3p Associate With Donor Age, BMI, and Sex and Mediate Cellular Aging in Islet‐Derived Cells

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Objectives Human islets are widely researched to understand pathophysiological mechanisms leading to diabetes. Sex, age, and body mass index (BMI) are key donor traits influencing islet function, which is also regulated by an intricate network of microRNAs.
Wilson K. M. Wong, Isabelle El‐Azzi, Aditya Nachanekar, Ehsan Alvandi, Nhan Ho Trong Pham, Hrishikesh P. Hardikar, Mya Polkamp, Vijit Saini, Feifei Cheng, Guozhi Jiang, Anja E. Sørensen, Yi Vee Chew, Helen E. Thomas, Thomas Loudovaris, Ronald C. W. Ma, Wayne J. Hawthorne, Louise T. Dalgaard, Mugdha V. Joglekar, Anandwardhan A. Hardikar   +18 more
wiley   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Effects of Glucagon‐Like Peptide‐1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat‐free mass and fat mass losses) and mass‐independent adaptations in EE (e.g., hormones). Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are indicated for obesity management; however, their effects on EE remain unclear ...
Flavio T. Vieira, ZhiDi Deng, Manfred J. Muller, Giovanna G. L. Bergamasco, Sarah Cawsey, Melania Manco, Steven B. Heymsfield, Carla M. Prado, Andrea M. Haqq   +8 more
wiley   +1 more source

An epigenome atlas of mouse adipocytes

Molecular Metabolism
Objective: Epigenetic modifications including histone post translational modifications can influence gene expression in adipocytes, potentially contributing to metabolic dysfunctions, obesity, and insulin resistance.
Laura C. Hinte, Adhideb Ghosh, Daniel Castellano-Castillo, Christian Wolfrum, Ferdinand von Meyenn   +4 more
doaj   +1 more source