Results 91 to 100 of about 1,797,962 (199)
Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes
Frontiers in Endocrinology, 2020 Brown adipose tissue (BAT) and beige adipose tissue dissipate metabolic energy and mediate nonshivering thermogenesis, thereby boosting energy expenditure. Increasing the browning of BAT and beige adipose tissue is expected to be a promising strategy for
Ya-Nan Duan +9 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild +3 more
wiley +1 more source
Molecular Metabolism, 2016 Objective: Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism.
Marina T. DiStefano +11 more
doaj +1 more source
Nature Communications, 2023 Thermogenic beige fat can reduce fat mass and improve metabolic health, yet the ability to form beige fat rapidly declines with age. Here, the authors show that targeting the age-related ramping of Pdgfrβ signalling restores the ageing adipose tissue ...
Abigail M. Benvie +5 more
doaj +1 more source
Obesity Reviews, Volume 27, Issue 10, October 2026.ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye +6 more
wiley +1 more source
The transcription factor Prep1 regulates adipose tissue functions [PDF]
, 2014 2012 - 2013Adipose tissue is crucial for maintaining energy and metabolic homeostasis and its functionality is closely related to the adipocytes differentiation state. Adipogenesis is regulated by several transcription factors.
Liotti, Antonietta
core +1 more source
Advanced Science, Volume 13, Issue 50, 7 September 2026.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani +4 more
wiley +1 more source
Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors [PDF]
, 2017 Formation of beige adipocytes within white adipose tissue enhances energy expenditure, which is a promising strategy to reduce obesity and prevent metabolic symptoms.
Min Du +23 more
core +1 more source
Involvement of Alternative Splicing Regulation in Adipose Tissue Thermogenic Induction [PDF]
, 2023 [eng] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins.
Castellá Giner, Moisés
core +1 more source