Results 131 to 140 of about 172,738 (259)

Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? [PDF]

, 2017
Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological ...
Agra, Agra, Alexander, Alexander, Alexander, Alexopoulos, Arora, Baessler, Bakkum, Balcioglu, Berridge, Berry, Bers, Bers, Bełtowski, Bian, Burgeiro, Burridge, Castro, Chechi, Cheng, Chilukoti, Chiu, Daya, Dekker, Deng, Deng, Dobrzynski, Dong, Du, Eisner, Elie, Elisha, Engler, Fain, Fandino-Vaquero, Fernandez-Trasancos, Fosshaug, Frankel, Furuhashi, Gaborit, Gaborit, Gao, Georgiou, Ghantous, Gho, Goncalves, Greif, Greulich, Greulich, Greulich, Gruen, Guauque-Olarte, Haemers, Harada, Hassan, Hatem, Hatem, Hatem, Heijman, Heijman, Hua, Hung, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Iacobellis, Imoto-Tsubakimoto, Iozzo, Itoh, Janik, Karastergiou, Kaushik, Kazumi, Kim, Kim, Kitagawa, Kleinz, Kusayama, Lage, Lamounier-Zepter, Lamounier-Zepter, Langheim, Leeper, Li, Lim, Lip, Look, MacQueen, Maghbooli, Mahabadi, Mahabadi, Marchington, Marchington, Margaritis, Martinsen, Matloch, Mattacks, Mattacks, Mattacks, Mazurek, Mazurek, Mazzoccoli, McAninch, Mookadam, Nakanishi, Nevelsteen, Nicholls, O'Connell, Pang, Paolisso, Parisi, Pezeshkian, Phillips, Pierdomenico, Pond, Pontes Soares, Prati, Rabkin, Rachwalik, Rainwater, Rajapurohitam, Rodriguez-Penas, Sacks, Sacks, Sacks, Sade, Salgado-Somoza, Samanta, Sarin, Scimia, Shapira-Schweitzer, Shibasaki, Shimabukuro, Siegel-Axel, Silaghi, Smith, Song do, Southan, Spiroglou, Szokodi, Takebayashi, Talman, Teijeira-Fernandez, Vacca, Venteclef, Viscogliosi, Voigt, Vural, Weikert, Westcott, White, Willens, Wong, Xu, Yamaguchi, Yañez-Rivera, Ye, Yilmaz, Zdychova, Zeng, Zhou   +164 more
core   +1 more source

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This study identifies that REGγ is elevated in obese adipose tissue. REGγ modulates WAT browning via ubiquitin‐independent ACADM/KLF15–UCP1 degradation. Overactivation of the NRF2–REGγ axis facilitates adipose tissue function to cause obesity. Inhibition of REGγ in the iWAT alleviates HFD‐induced obesity.
Hui Chen, Qiujing Guan, Shuangming Gong, Yingying Du, Zhidan Zhang, Yan Liu, Lei Zhou, Lin Liu, Baoquan Xin, Yilan Guo, Hui Zhang, Ziyang Zhou, Tongchao Pei, Guohong Yu, Sokun Yin, Lei Li   +15 more
wiley   +1 more source

The Role of β3-Adrenergic Receptors in Cold-Induced Beige Adipocyte Production in Pigs

Cells
After exposure to cold stress, animals enhance the production of beige adipocytes and expedite thermogenesis, leading to improved metabolic health.
Shuo Yang, Hong Ma, Liang Wang, Fang Wang, Jiqiao Xia, Dongyu Liu, Linlin Mu, Xiuqin Yang, Di Liu   +8 more
doaj   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. [PDF]

, 2019
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes.
A Balkow, A Bartelt, AM Cypess, Ayano Ueno, B Tasic, C Jang, Carlos Henrique Sponton, CB Newgard, CB Newgard, CJ Lynch, CR Green, CT Ferrara, DE Lackey, EG Sustarsic, F Palmieri, Francis C. Szoka, H Ohno, Haruya Takahashi, Hiroko Maki, Homa Majd, Huixia Li, K Ikeda, K Shinoda, Kaori Igarashi, Kazuki Tajima, KC Das, Kenji Ikeda, KH Pietiläinen, KM Huffman, Kyeongkyu Kim, LA Gilbert, Labros Sidossis, M Chondronikola, M Rosell, M Saito, M Wallace, MA Herman, Maki Ohishi, Mami Matsushita, Maria Chondronikola, Masayuki Saito, MD Neinast, Michael T. McManus, Mito Kuroda, Momoko Yoneshiro, Olga R. Ilkayeva, P She, Phillip J. White, PJ White, PJ White, Qiang Wang, Rachana N. Pradhan, Robert W. McGarrah, SH Um, Shingo Kajimura, T Li, T Soga, T Soga, T Yoneshiro, Takamasa Ishikawa, Takeshi Yoneshiro, Teruo Kawada, TJ Wang, Tomoyoshi Soga, Tsuyoshi Goto, V Ouellet, Vanille Juliette Greiner, X Kong, Yann Deleye, Yasuo Oguri, Yong Chen, Zachary Brown, Zhipeng Dai   +72 more
core   +1 more source

Advantage of Semaglutide: Comprehensive Analysis of Metabolic Impact of Semaglutide‐Treated and Pair‐Fed Rats

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Semaglutide, GLP‐1 receptor agonist, offers metabolic benefits that far outweigh those offered by comparable caloric restriction. Its mechanism of action involves hypophagia but also adipose tissue remodeling and browning. Semaglutide targeted thermogenesis via alternation in the thyroid axis and sympathetic input to BAT.
Suyeun Byun, Morgan R. Sotzen, Mya A. Knappenberger, Madison T. Bento, Mohammed Asker, Doris I. Olekanma, Karolina P. Skibicka   +6 more
wiley   +1 more source

Peptidoglycan inhibits beigeing of adipose tissue

Acta Pharmaceutica Sinica B, 2022
Hong Chen, Lijun Sun, Lu Feng, Michael Mulholland, Weizhen Zhang, Yue Yin   +5 more
openaire   +3 more sources

Ontogeny and thermogenic role for sternal fat in female sheep [PDF]

, 2017
Brown adipose tissue acting through a unique uncoupling protein (UCP1) has a critical role in preventing hypothermia in new-born sheep but is then considered to rapidly disappear during postnatal life.
Albrecht, Alexander, Alexander, Atit, Bal, Barquissau, Basse, Belinda A. Henry, Bispham, Blessing, Blondin, Bloor, Cantile, Cao, Christian, Christodoulides, Clapham, Clarke, Clarke, Clarke, de Jong, Ellis, Elsen, Forner, Gburcik, Harms, Helen Budge, Henry, Henry, Henry, Henry, Horvath, Hotta, Hunt, Iain J. Clarke, John-Paul Fuller-Jackson, Kiskinis, Kooijman, Kurose, Lean, Lee, Lee, Loomis, Macotela, Mark Birtwistle, Mark Pope, Michael E. Symonds, Moldes, Møller, Nedergaard, Nedergaard, Nygaard, Ojha, Ootsuka, Petrovic, Pope, Rachael Loughnan, Ramayo-Caldas, Reham Alagal, Rosell, Rowland, Sacks, Sanchez-Gurmaches, Sanchez-Gurmaches, Scheele, Scotney, Seale, Sechen, Shan, Shinoda, Symonds, Symonds, Symonds, Symonds, Symonds, Symonds, Symonds, Timmons, van Marken Lichtenbelt, Vergnes, Virtanen, Viv Perry, Wellik, Xue, Yamamoto   +84 more
core   +2 more sources

Fighting obesity by targeting factors regulating beige adipocytes. [PDF]

, 2018
Purpose of reviewThe current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.Recent findingsWe outline recent studies ...
Koliwad, Suneil K, McQueen, Allison E, Wang, Jen-Chywan   +2 more
core   +1 more source

Diffuse optical spectroscopy and imaging to detect and quantify adipose tissue browning [PDF]

, 2017
Adipose (fat) tissue is a complex metabolic organ that is highly active and essential. In contrast to white adipose tissue (WAT), brown adipose tissue (BAT) is deemed metabolically beneficial because of its ability to burn calories through heat ...
Balasundaram, G., Dinish, U. S., Olivio, M., Ong, Wee Kiat, Sriram, S., Sugii, S., Wong, C. L.   +6 more
core   +1 more source