Results 111 to 120 of about 38,129 (248)

RETRACTED: Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice

Antioxidants, 2020
Excessive lipid accumulation in white adipose tissue (WAT) results in adipocyte hypertrophy and chronic low-grade inflammation, which is the major cause of obesity-associated insulin resistance and consequent metabolic disease.
Hsin-Hsueh Shen, S. Peterson, L. Bellner, Abu Choudhary, Lior Levy, Leah Gancz, Ariel Sasson, Joseph Trainer, R. Rezzani, Abraham Resnick, D. Stec, N. Abraham   +11 more
semanticscholar   +1 more source

Dual‐Targeted Glucose‐Dependent Insulinotropic Polypeptide‐Loaded Photothermal Nanoparticles to Prevent Obesity via Lipolysis and Browning of White Adipose Tissue

Small Science, EarlyView.
Current weight‐loss medications inevitably cause adverse effects such as depression or muscle loss. The developed GIP/ICG@P/R8 NPs specifically promoted energy expenditure by inducing browning, lipolysis and apoptosis of WAT in vitro and in vivo. The results showed a 9.23% weight reduction after 14 days, enhanced insulin sensitivity, improved fatty ...
Ting Xie, Lutang Zhao, Shurui Pei, Kaikai Wen, Sijia Fei, Wan Chen, Zhengyang Li, Long Zhang, Linlin Li, Lixin Guo, Hui Huang, Qi Pan   +11 more
wiley   +1 more source

Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress [PDF]

, 2018
Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity.We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO- 1)
Abraham, Nader G., Bamshad, David, Bellner, Lars, Favero, Gaia, Grant, Ilana, Lebovics, Edward, Meissner, Aliza, Raffaele, Marco, Rezzani, Rita, Rodella, Luigi F., Sacerdoti, David, Schragenheim, Joseph, Singh, Shailendra P., Vanella, Luca   +13 more
core   +1 more source

Nbeal2 Inactivation Triggers Abl1 Stabilisation and Dysregulated Subcellular Localisation of the Multi‐Drug‐Resistant Protein MDR1 (ABCB1) in Mast Cells

Immunology, EarlyView.
(A) Proposed model for Abl1 degradation via Nbeal2. Nbeal2 interacts with Abl1 with its WDR domain. This results in proteasomal degradation by a yet unidentified ubiquitin ligase. Therefore, Nbeal2 inactivation stabilises Abl1, which supports mast cell (MC) degeneration. (B) In wt MCs, the Abl1 protein level is controlled by Nbeal2. Furthermore, Nbeal2
Raphaela Marquardt, Nico Andreas, Ronja Herrnberger, Claudia Küchler, Katrin Hornung, Bernhard Nieswandt, Marco Groth, Paul M. Jordan, Oliver Werz, Julia Drube, Sebastian Drube   +10 more
wiley   +1 more source

Optical imaging for brown or beige adipose tissue

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Currently, one in three adults worldwide may be obese or overweight. Obesity is characterized by an excess of energy‐storing white fat. An ingenious and sought‐after strategy against obesity is to activate energy‐consuming beige fat, which is converted ...
Jiamin Liu, Linjie Ni, Minmin Peng, Yiying Liang, Chan Lu, Hanying Zheng, Zicheng Huang, Jinde Zhang, Ronghe Chen   +8 more
doaj   +1 more source

Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity

Cell Reports, 2018
Caloric restriction (CR) is standard lifestyle therapy in obesity management. CR-induced weight loss improves the metabolic profile of individuals with obesity.
Valentin Barquissau, Benjamin Léger, Diane Beuzelin, Frédéric Martins, Ez-Zoubir Amri, Didier F. Pisani, Wim H.M. Saris, Arne Astrup, Jean-José Maoret, Jason Iacovoni, Sébastien Déjean, Cédric Moro, Nathalie Viguerie, Dominique Langin   +13 more
doaj   +1 more source

Amino acids contribute to adaptive thermogenesis. New insights into the mechanisms of action of recent drugs for metabolic disorders are emerging

Pharmacological Research, 2023
Adaptive thermogenesis is the heat production by muscle contractions (shivering thermogenesis) or brown adipose tissue (BAT) and beige fat (non-shivering thermogenesis) in response to external stimuli, including cold exposure.
Chiara Ruocco, Alexis Elias Malavazos, Maurizio Ragni, Michele O. Carruba, Alessandra Valerio, Gianluca Iacobellis, Enzo Nisoli   +6 more
doaj   +1 more source

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

The 20 kDa isoform of the human growth hormone variant alters adipose and muscle gene expression differently than human growth hormone

Journal of Neuroendocrinology, EarlyView.
Abstract The 20 kDa isoform of human growth hormone variant (20K hGH‐V) (derived from the GH2 gene) has previously been shown to promote growth but lacks the diabetogenic and lactogenic activities of human GH (derived from the GH1 gene). That is, 20K hGH‐V‐treated mice have similar body size and composition to hGH‐treated mice, as well as improved ...
Jonathan A. Young, Jolie Bogart, Mat Buchman, Silvana Duran‐Ortiz, Stephen Bell, John J. Kopchick, Darlene E. Berryman, Edward O. List   +7 more
wiley   +1 more source

Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity

International Journal of Endocrinology, 2016
All mammals own two main forms of fat. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue instead of inducing fat ...
Fernando Lizcano, Diana Vargas
doaj   +1 more source