Results 61 to 70 of about 38,179 (226)
Nature Communications, 2021 Visceral adiposity is a risk factor for cognitive decline, but subcutaneous adipose tissue (SAT) is not and may be protective. Here, the authors show that beige adipocytes are indispensable for the neuroprotective effects of SAT.
De-Huang Guo +5 more
doaj +1 more source
PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]
, 2019 (1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M +9 more
core +1 more source
How Does Fat Transition from White to Beige? [PDF]
Cell Metabolism, 2017 Fischer et al. (2017) recently reported that interleukin-4 (IL-4) does not increase adipose thermogenesis and that activated macrophages do not synthesize catecholamines. These findings are unexpected because IL-4 activation of macrophages has been proposed to have a pivotal role in cold-induced thermogenesis by stimulating macrophage catecholamine ...
Marc L. Reitman
openalex +3 more sources
Imaging adipose tissue browning using the TSPO-18kDa tracer [18F]FEPPA
Molecular Metabolism, 2019 Objectives: The browning of white adipose tissue (WAT) into beige has been proposed as a strategy to enhance energy expenditure to combat the growing epidemic of obesity.
S.V. Hartimath +8 more
doaj +1 more source
Morphogenetics in brown, beige and white fat development [PDF]
Adipocyte, 2016 Brown and beige (or brite) fat cells are capable of evoking non-shivering thermogenesis in response to cold and β-adrenergic stimulation. By metabolizing lipids and carbohydrate via uncoupled respiration these cells directly convert energy to heat.
Jean Z, Lin, Stephen R, Farmer
openaire +2 more sources
Notch signaling regulates adipose browning and energy metabolism [PDF]
, 2014 Beige adipocytes in white adipose tissue (WAT) are similar to classical brown adipocytes in that they can burn lipids to produce heat. Thus, an increase in beige adipocyte content in WAT browning would raise energy expenditure and reduce adiposity.
Bi, Pengpeng +10 more
core +5 more sources
Adipose tissue browning for the treatment of obesity and metabolic diseases [PDF]
CellR4, 2020 Adipose tissue is the most abundant endocrine organ in humans with an important influence on many events throughout life. Many studies that highlight the different phenotypic characteristics of fat cells in adults are becoming more frequent. Perhaps, one
F. Arroyave, D. Montaño, F. Lizcano
doaj +1 more source
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms [PDF]
, 2015 Objectives: The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.
Clark, S. +10 more
core +3 more sources
miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]
, 2020 microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria +6 more
core +1 more source
Metabolic regulation and the anti-obesity perspectives of human brown fat
Redox Biology, 2017 Activation of brown adipose tissue (BAT) in adult humans increase glucose and fatty acid clearance as well as resting metabolic rate, whereas a prolonged elevation of BAT activity improves insulin sensitivity.
Camilla Scheele, Søren Nielsen
doaj +1 more source