Results 61 to 70 of about 38,129 (248)

Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II. [PDF]

Proc Natl Acad Sci U S A, 2020
Significance Adipose tissue-derived mesenchymal stem cells (ADSCs) are well-known in the generation of both white and beige adipocytes and the maintenance of adipose tissue homeostasis.
Liu K, Lin L, Li Q, Xue Y, Zheng F, Wang G, Zheng C, Du L, Hu M, Huang Y, Shao C, Kong X, Melino G, Shi Y, Wang Y.   +14 more
europepmc   +2 more sources

Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation. [PDF]

Dev Cell, 2020
Jun H, Ma Y, Chen Y, Gong J, Liu S, Wang J, Knights AJ, Qiao X, Emont MP, Xu XZS, Kajimura S, Wu J.   +11 more
europepmc   +2 more sources

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis [PDF]

Cell, 2014
Minwoo Lee, Justin I. Odegaard, Lata Mukundan, Yifu Qiu, Ari B. Molofsky, Jesse C. Nussbaum, Karen Yun, Richard M. Locksley, Ajay Chawla   +8 more
openalex   +2 more sources

Combating Obesity With Thermogenic Fat: Current Challenges and Advancements

Frontiers in Endocrinology, 2020
Brown fat and beige fat are known as thermogenic fat due to their contribution to non-shivering thermogenesis in mammals following cold stimulation. Beige fat is unique due to its origin and its development in white fat.
Ruping Pan, Xiaohua Zhu, Pema Maretich, Yong Chen   +3 more
doaj   +1 more source

TGF-β receptor 1 regulates progenitors that promote browning of white fat

Molecular Metabolism, 2018
Objective: Beige/brite adipose tissue displays morphological characteristics and beneficial metabolic traits of brown adipose tissue. Previously, we showed that TGF-β signaling regulates the browning of white adipose tissue. Here, we inquired whether TGF-
Umesh D. Wankhade, Ji-Hyeon Lee, Pradeep K. Dagur, Hariom Yadav, Michael Shen, Weiping Chen, Ashok B. Kulkarni, J. Philip McCoy, Toren Finkel, Aaron M. Cypess, Sushil G. Rane   +10 more
doaj   +1 more source

β₃-Adrenergic receptor agonist treats rotator cuff fatty infiltration by activating beige fat in mice. [PDF]

J Shoulder Elbow Surg, 2021
Wang Z, Liu X, Liu M, Jiang K, Kajimura S, Kim H, Feeley BT.   +6 more
europepmc   +2 more sources

Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice

Nature Communications, 2021
Visceral adiposity is a risk factor for cognitive decline, but subcutaneous adipose tissue (SAT) is not and may be protective. Here, the authors show that beige adipocytes are indispensable for the neuroprotective effects of SAT.
De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Alexis M. Stranahan   +5 more
doaj   +1 more source

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]

, 2019
(1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M, Lusis, Aldons J, Meng, Yonghong, Reddy, Srinivasa T, Reue, Karen, Sallam, Tamer, Shih, Diana M, Shu, Michelle L, Tontonoz, Peter, Vergnes, Laurent   +9 more
core   +1 more source

Imaging adipose tissue browning using the TSPO-18kDa tracer [18F]FEPPA

Molecular Metabolism, 2019
Objectives: The browning of white adipose tissue (WAT) into beige has been proposed as a strategy to enhance energy expenditure to combat the growing epidemic of obesity.
S.V. Hartimath, S. Khanapur, R. Boominathan, L. Jiang, P. Cheng, F.F. Yong, P.W. Tan, E.G. Robins, J.L. Goggi   +8 more
doaj   +1 more source

Brite/beige fat and UCP1 — is it thermogenesis?

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2014
The presence of two distinct types of adipose tissue, which have opposing functions, has been known for decades. White adipose tissue (WAT) is the main tissue of energy storage, while brown adipose tissue (BAT) dissipates energy as heat and is required for non-shivering thermoregulation.
Martin Jastroch, Susanne Keipert
openaire   +3 more sources