Results 131 to 140 of about 2,472,934 (283)

Use Of Fuzzy Logic For Risk/Benefit Assessment In Medical/Biological Cases [PDF]

, 2012
In recent decade safety of medical and biological products has been concerned in the light of benefit/risks and risk assessment. For new medical products and new drugs, unanticipated side effects that rise after consuming the new product is a dominant ...
Keivani Hafshejani, Maryam., Langari, Ameneh., Mohammadsharifi, Aboosaleh., Sattari Naeini, Manochehr., Yahiapoor, Mohammad taghi.   +4 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Quantitative Benefit-Risk Assessment of COVID-19 Vaccines Using the Multi-Criteria Decision Analysis. [PDF]

Vaccines (Basel), 2022
Son KH, Kwon SH, Na HJ, Baek Y, Kim I, Lee EK.   +5 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Dietary Studies, Guidelines and Recommendations: Limited Nutrient Deficiency Risks and Significant Modelled Health Benefits in French Adults Following a More Plant-Based Diet

Proceedings
There is a current trend towards plant-based diets in Western countries. These diets have been associated with long-term health benefits but could limit the adequacy of some indispensable nutrients.
Pauline Mombert, Jean-François Huneau, Juhui Wang, Jeanne-Marie Membré, François Mariotti   +4 more
doaj   +1 more source

Multimethod quantitative benefit-risk assessment of treatments for moderate-to-severe osteoarthritis. [PDF]

Br J Clin Pharmacol, 2022
Mauer J, Bullok K, Watt S, Whalen E, Russo L, Junor R, Markman J, Hauber B, Tervonen T.   +8 more
europepmc   +1 more source

Applying Real Options Thinking to Information Security in Networked Organizations [PDF]

, 2006
An information security strategy of an organization participating in a networked business sets out the plans for designing a variety of actions that ensure confidentiality, availability, and integrity of company’s key information assets.
Daneva, M.
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Integrating environmental sustainability into food-based dietary guidelines in the Nordic countries

Food & Nutrition Research
The overall aim of this paper was to provide background knowledge to the Nordic Nutrition Recommendations 2023 Committee for integrating environmental sustainability in a framework for national Food-Based Dietary Guidelines (FBDG) within the Nordics and ...
Ellen Trolle, Jelena Meinilä, Hanna Eneroth, Helle Margrete Meltzer, Inga Þórsdóttir, Thorhallur Halldorsson, Maijaliisa Erkkola   +6 more
doaj   +1 more source