Results 61 to 70 of about 1,384,561 (311)
Frontiers in Pharmacology, 2014 The assessment report formats of four major regulatory reference agencies, US Food and Drug Administration, European Medicines Agency, Health Canada, and Australia’s Therapeutic Goods Administration were compared to a benefit-risk (BR) documentation ...
James eLeong Wai Yeen +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Fate of Phosphate: Assessing Dietary Intake and Urinary Excretion in Swedish Adolescents
Current Developments in NutritionBackground: A high total phosphorus (P) intake has been proposed to promote endothelial dysfunction and atherosclerosis. A diet rich in foods containing P additives could contribute to an excessive intake, potentially reflected as increased concentration
Fredrik Söderlund +9 more
doaj +1 more source
On long-term credit risk assessment and rating : Towards a new set of models [PDF]
, 2009 Technical ReportInstitutional investors are supposed to assess credit risk by using a combination of quantitative information such as option models and qualitative assessments.
Kubo, Hideya, Sakai, Yasuhiro
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, 2023 The purpose of the national risk assessment is to anticipate relatively sudden incidents potentially targeted at Finland that call for activities deviating from the norm from authorities or even requesting help from other countries.
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
, 2020 improving their operations with a view to human health and environmental awareness. Many methods with different rationales have been existed in the literature to prioritize hazards according to their risk levels and to mitigate their consequences.
Ak, M. Fatih +2 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
, 2009 This thesis concentrates on uncertainty and variability in the risk assessment methodology for industrial chemicals as applied within the current regulatory framework for industrial chemicals in Europe, REACH (Registration, Evaluation, Authorisation and ...
Vermeire, T.G. +2 more
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