Results 71 to 80 of about 1,384,561 (311)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Food Frontiers4D printing, an evolution of 3D printing, introduces the dimension of time to enable printed structures to undergo transformations when exposed to external stimuli.
Shengyang Ji +6 more
doaj +1 more source
Environment InternationalRelatively little is known about the relationship between socio-demographic factors and the chemical exposome in adolescent populations. This knowledge gap hampers global efforts to meet certain UN sustainability goals.
Sebastian Pineda +8 more
doaj +1 more source
Can Standardisation of the Public Assessment Report Improve Benefit-Risk Communication?
Frontiers in Pharmacology, 2020 BackgroundNational regulatory authorities (NRAs) make the decision to register a medicine based on an assessment of its benefits and risks and publicly available assessment reports are used as a tool to communicate the basis for the decision.
Andrea Keyter +6 more
doaj +1 more source
Advancing the Contribution of Occupational Epidemiology to Risk Assessment
, 2011 The identification and quantification of risk factors that are characterized by low exposure levels, moderately increased risks, and unspecific exposure-disease relations is a major challenge facing risk assessment today.
Vlaanderen, J.J. +2 more
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
A practical approach to communicating benefit-risk decisions of medicines to stakeholders
Frontiers in Pharmacology, 2015 PurposeThe importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and ...
James eLeong +3 more
doaj +1 more source
Challenges of quantitative microbial risk assessment at EU level.
, 2009 Quantitative microbial risk assessment (QMRA) aims to model the fate of pathogenic micro-organisms along the food chain and the associated health risks.
Evers, E.G. +4 more
core
Risk assessment of N-nitrosodimethylamine formed endogenously after fish-with-vegetable meals
, 2010 The consumption of fish and nitrate-rich vegetables may lead to the formation of the genotoxic carcinogen N-nitrosodimethylamine (NDMA) in the stomach. To assess human cancer risk associated with this formation, a dynamic in vitro gastrointestinal model ...
Slob, W. +5 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source