Results 91 to 100 of about 8,117 (271)
重症好酸球性喘息におけるベンラリズマブによる粘液栓への効果 [PDF]
, 2023 新潟大学Niigata University博士（医学）Introduction: Mucus plugs are associated with airway obstruction in severe asthma and are involved in the formation of activated eosinophils.
Sakai, Natsumi, 酒井, 菜摘
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Clinical &Experimental Allergy, EarlyView.ABSTRACT The introduction of biologics, such as benralizumab (an anti‐IL‐5 receptor α humanised monoclonal antibody), has made remission a feasible goal for patients with severe eosinophilic asthma (SEA). However, there are remaining research gaps and no clear consensus on the definition of remission.
Renaud Louis +7 more
wiley +1 more source
Clinical and Lung Function Outcomes After Anti-IgE or Anti-IL5 Therapy in Severe Asthma
Journal of Asthma and Allergy, 2022 Saad AlShareef,1 Christine F McDonald,2– 4 Joy Lee2,5 1Department of Medicine, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317-4233, Saudi Arabia; 2Department of Respiratory and Sleep Medicine, Austin Health ...
AlShareef S, McDonald CF, Lee J
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Dupilumab efficacy in uncontrolled, moderate-to-severe asthma with self-reported chronic rhinosinusitis [PDF]
, 2019 BACKGROUND: Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for IL-4 and IL-13 signaling, key drivers of type 2 inflammation.
Castro, Mario, et al,, Maspero, Jorge F
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Journal of the European Academy of Dermatology and Venereology, EarlyView.This large‐scale, propensity‐matched retrospective cohort study provides evidence that dupilumab treatment during pregnancy is not associated with an elevated risk of maternal adverse pregnancy outcomes (APOs). By utilizing real‐world data, it contributes critical insights into dupilumab's safety profile in pregnant women, addressing a crucial gap in ...
Sophie L. Preuß +9 more
wiley +1 more source
Tackling "people remodelling" in corticosteroid-dependent asthma with type-2 targeting biologics and a formal corticosteroid weaning protocol [PDF]
, 2022 : People with severe corticosteroid-dependent asthma have greater morbidity, mortality and corticosteroid side effects than any other people with asthma. Just as type-2 inflammation and recurrent asthma attacks remodel airways, we propose the concept of ‘
Couillard, Simon +2 more
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The Dental Status of Patients Taking Common Biologic Agents: A Single‐Center Cross‐Sectional Study
Oral Diseases, EarlyView.ABSTRACT Objectives Despite expanding use and medical applications, little is known about the impact of biologic agents (BAs) on dental treatment. The aim of this study was to investigate the dental status of patients on common classes of BAs to understand treatment needs and use in this population.
Shivani Shah +4 more
wiley +1 more source
Journal of Asthma and Allergy, 2018 Michel Aubier,1–4 Gabriel Thabut,1–3,5 Caroline Fabry-Vendrand6 1Inserm UMR1152, Physiopathology and Epidemiology of Respiratory Diseases, Paris, France; 2Faculty of Medicine, Paris Diderot University, Paris, France; 3Laboratory of Excellence,
Aubier M, Thabut G, Fabry-Vendrand C
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Heliyon, 2022 Background and aims: Biologics that target Type 2 inflammation are effective in reducing exacerbations of severe asthma. We conducted a systematic review and integrated analysis of the efficacy and safety of these biologics in chronic obstructive ...
Hiroshi Ohnishi +2 more
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Real-life cost-effectiveness of benralizumab in patients with severe asthma
Respiratory Research, 2021 Background Availability of clinically effective and cost-effective treatments for severe asthma would be beneficial to patients and national healthcare systems.
A. Padilla-Galo +10 more
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