Results 91 to 100 of about 16,181 (141)

Assembling an isomer grid: the isomorphous 4-, 3- and 2-fluoro-N'-(4-pyridyl)benzamides [PDF]

, 2008
The three title isomers, 4-, (I), 3-, (II), and 2-fluoro-N'-(4-pyridyl)benzamide, (III), all C₁₂H₉FN₂O, crystallize in the P21/c space group (No. 14) with similar unit-cell parameters and are isomorphous and isostructural at the primary hydrogen-bonding ...
Donnelly, Katie, Gallagher, John F., Lough, Alan J.   +2 more
core   +1 more source

Multiple Atropo Selectivity by κ2‐N,O‐Oxazoline Urea Ligands in Cobaltaelectro‐Catalyzed C─H Activations: Decoding Selectivity with Data Science Integration

ChemistryEurope, Volume 3, Issue 3, May 2025.
Cobaltaelectro‐catalyzed C─H activation enables simultaneous construction of indoles with up to two distinct C─N chiral axes. High stereoselectivity derives from newly developed chiral κ2‐N,O‐oxazoline urea ligands. Multivariate linear regression modeling reveals ligand–substrate features affecting the second C─N chiral axis, and density functional ...
Philipp Boos, Neeraj Kumar Pandit, Suman Dana, Tristan von Münchow, Airu Hashidoko, Laura Haberstock, Regine Herbst‐Irmer, Dietmar Stalke, Lutz Ackermann   +8 more
wiley   +1 more source

Unlocking Catalysis Using Oxidatively Induced Reductive Elimination

Chemistry – A European Journal, Volume 31, Issue 18, March 25, 2025.
Oxidatively induced reductive elimination (OIRE) has become a crucial chemical process in C−H bond functionalisation catalysis, allowing the formation of otherwise much less accessible products. The progress made in this field is addressed, highlighting the role played by specific metals in its development, and recaps the state of the art in the ...
Carmen Antuña‐Hörlein, Jean‐Pierre Djukic   +1 more
wiley   +1 more source

Advances in the Release of Amide‐Containing Molecules

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The ability to release a molecule from a larger construct in a controlled manner is of great importance to produce effective prodrugs, antibody‐drug conjugates, and chemical probes. Amides are ubiquitous functional groups, yet methods to utilise them as molecular release handles are seldom reported.
Thomas Wharton, David R. Spring
wiley   +1 more source

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model [PDF]

, 2011
NOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of Disease. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Acquaviva, Al-Mahdawi, Al-Mahdawi, Al-Mahdawi, Antos, Bradley, Butler, Campuzano, Campuzano, Cang, Chiranjeevi Sandi, Chou, Clark, Cossee, De Biase, Drummond, Garbes, Glenn Barnes, Gottesfeld, Grabczyk, Greene, Hahnen, Herman, Hockly, James R. Rusche, Joel M. Gottesfeld, Kernochan, Koeppen, Koeppen, Mark A. Pook, Monneret, Pandolfo, Pook, Prince, Puccio, Rai, Rai, Reid, Ricardo Mouro Pinto, Riessland, Rotig, Rufini, Sahar Al-Mahdawi, Saveliev, Schulz, Simon, Soragni, Steve Jones, Thomas, Vahid Ezzatizadeh, Wells, Xu   +51 more
core   +2 more sources

Continuous Flow Synthesis of β‐Aminoketones as Masked Vinyl Ketone Equivalents

Chemistry – A European Journal, Volume 31, Issue 19, April 1, 2025.
We report an efficient and scalable method for the generation of β‐aminoketones from amides and Grignard reagents. The continuous process operates at elevated temperatures and uses a plate‐based reactor exploiting a hydrophobic internal coating to avoid reactor fouling issues due to the heterogeneous reaction mixture. The unmasking of the β‐aminoketone
Ruairi Bannon, Megan Smyth, Thomas S. Moody, Scott Wharry, Philippe M. C. Roth, Guillaume Gauron, Marcus Baumann   +6 more
wiley   +1 more source

Disruption of salt bridge interactions in the inter‐domain cleft of the tubulin‐like protein FtsZ of Escherichia coli makes cells sensitive to the cell division inhibitor PC190723

Cytoskeleton, EarlyView.
Abstract FtsZ forms a ring‐like assembly at the site of division in bacteria. It is the first protein involved in the formation of the divisome complex to split the cell into two halves, indicating its importance in bacterial cell division. FtsZ is an attractive target for developing new anti‐microbial drugs to overcome the challenges of antibiotic ...
Sakshi Mahesh Poddar, Joyeeta Chakraborty, Pananghat Gayathri, Ramanujam Srinivasan   +3 more
wiley   +1 more source

A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues [PDF]

, 2017
For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl) benzoyl chloride.
Heugebaert, Thomas, Kerchev, Pavel, Stevens, Christian, Van Breusegem, Frank, van der Meer, Tom, Verlee, Arno   +5 more
core   +3 more sources

Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300

ChemMedChem, EarlyView.
Two PROTAC‐based degraders targeting the cancer‐associated transcriptional co‐activators CBP/p300 weredeveloped. These degraders, combining the CBP/p300 inhibitor C646 with the CRBN ligand thalidomide, reduced CBP/p300 levels in lymphoma cells at low‐micromolar concentration.
Francesco Fiorentino, Filippo Spriano, Daniela Tomaselli, Giorgia Risi, Emanuele Fabbrizi, Valeria Pecci, Simona Nanni, Francesco Bertoni, Dante Rotili, Antonello Mai   +9 more
wiley   +1 more source

The 68Ga-labeled chlorinated benzamide derivative: A novel PET imaging probe for detection of melanoma

Results in Chemistry
The benzamide structure is known for its ability to target melanin, a specific biomarker of melanoma. Therefore, we developed a new chlorinated benzamide structure for the detection of melanoma on positron emission tomography (PET). The derived benzamide
Yejin Seo, Dagyeong Hong, Eunsu Kim, Chaewon Lee, Boreum Song, Wookyeong Jeong, Jiyu Kim, Seong-Young Kwon, Dong-Yeon Kim, Ayoung Pyo   +9 more
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