Results 21 to 30 of about 16,181 (141)
Pharmaceutical Fronts, 2022 Targeting histone deacetylases (HDACs) has become an important focus in cancer inhibition. The pharmacophore of HDAC inhibitors (HDACis) reported so far is composed of three parts: a zinc-binding group (ZBG), a hydrophobic cavity-binding linker, and a ...
Xiu Gu +6 more
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The assessment of acute toxicity of 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide [PDF]
Вестник Витебского государственного медицинского университета, 2022 Objectives. To evaluate the acute toxicity of a benzamide derivative – 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide after a single intragastric administration to laboratory mice and rats.
O.G. Sechko, V.M. Tsarenkov
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Crystal structure of 4-methyl-N-{[1-(4-methylbenzoyl)piperidin-4-yl]methyl}benzamide
Acta Crystallographica Section E, 2014 In the title compound, C22H27N2O2, the piperidine ring adopts a half-chair conformation with the benzene rings inclined in a trans orientation with respect to the piperidine ring [dihedral angle between the benzene rings = 89.1 (1)°].
K. Prathebha +4 more
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Evaluation of melanin-targeted radiotherapy in combination with radiosensitizing drugs for the treatment of melanoma [PDF]
, 2014 The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. An [131I]-labeled benzamide - [131I]MIP-1145 - selectively targets melanin, reduces melanoma tumor burden and increases survival in preclinical ...
Babich, John +5 more
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Crystal structure of 4-chloro-N-[2-(piperidin-1-yl)ethyl]benzamide monohydrate
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C14H19ClN2O2·H2O, the piperdine ring adopts a chair conformation. The dihedral angle between the mean plane of the piperidine ring and that of the phenyl ring is 41.64 (1)°.
K. Prathebha +4 more
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Crystal structure of N-[(morpholin-4-yl)(thiophen-2-yl)methyl]benzamide
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C16H18N2O2S, the morpholine ring adopts a chair conformation. The thiophene ring makes a dihedral angle of 63.54 (14)° with the mean plane of the four C atoms [maximum deviation = 0.010 (3) Å] of the morpholine ring.
S. Arun Prabhu +4 more
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Highly active iridium(I) complexes for the selective hydrogenation of carbon-carbon multiple bonds [PDF]
, 2011 New iridium(I) complexes, bearing a bulky NHC/phosphine ligand combination, have been established as extremely efficient hydrogenation catalysts that can be used at low catalyst loadings, and are compatible with functional groups which are often ...
Andersson, Shalini +5 more
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N-Benzo[c][1,2,5]thiazol-4-yl-3-trifluoromethylbenzamide
Molbank, 2019 The title compound, N-benzo[c][1,2,5]thiazol-4-yl-3-trifluoromethylbenzamide (1) was synthesized by reacting 3-trifluoromethylbenzoyl chloride (4) and 4-aminobenzo[c][1,2,5]thiadiazole (5). The compound was characterized by various spectroscopic methods (
Hamad H. Al Mamari +2 more
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Acta Crystallographica Section E: Crystallographic Communications, 2020 The title compound, C15H15NO, is an enantiopure small molecule, which has been synthesized many times, although its crystal structure was never determined. By recrystallization from a variety of solvent mixtures (pure acetonitrile, ethanol–water, toluene–
Fermin Flores Manuel +2 more
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Acta Crystallographica Section E: Crystallographic Communications, 2021 Ionic co-crystals are co-crystals between organic molecules and inorganic salt coformers. Co-crystals of pharmaceuticals are of interest to help control polymorph formation and potentially improve stability and other physical properties.
Elizabeth Tinapple +2 more
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