Results 51 to 60 of about 16,181 (141)

Pharmacological evaluation of novel bioisosteres of an adamantanyl benzamide P2X7 receptor antagonist [PDF]

, 2017
Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of bioisosteres of benzamide 1 to explore improvements in the ...
Barron, Melissa L, Chishty, Mansoor, Fuller, Stephen, Hibbs, David E., Janssen, Bieneke, Kassiou, Michael, O'Brien-Brown, James, Ong, Jennifer A., Skarratt, Kristen K., Stokes, Leanne, Vugts, Danielle J., Werry, Eryn L., Wilkinson, Shane M, Windhorst, Albert D.   +13 more
core   +3 more sources

Visible‐Light Enabled Synthesis of 1‐Aryl‐3‐Sulfonylmethyl‐1,2,4‐Triazoles by Arylazo Sulfones

Advanced Synthesis &Catalysis, Volume 367, Issue 6, March 18, 2025.
Abstract We present a novel and highly efficient method for synthesizing polyfunctionalized 1,2,4‐triazoles. This approach leverages visible light and arylazo sulfones in combination with N‐vinyl amides, in the environmentally friendly solvent ethyl acetate.
Luca Nicchio, Lorenzo Di Terlizzi, Maurizio Fagnoni, Luc Neuville, Stefano Protti, Geraldine Masson   +5 more
wiley   +1 more source

Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides

Beilstein Journal of Organic Chemistry, 2017
Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination.
Ryota Miyaji, Yuuki Wada, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara   +4 more
doaj   +1 more source

Regioselective Palladaelectro‐Catalyzed Chlorination of Arenes in an Undivided Cell

Advanced Synthesis &Catalysis, Volume 367, Issue 6, March 18, 2025.
Abstract Chloroarenes constitute fundamental building blocks in organic synthesis and are widely applied in the synthesis of bioactive compounds, fine chemicals, materials, natural products and pharmaceuticals. Electrochemical chlorination has been recognized as a promising synthetic method for accessing chloroarenes, but it has proved challenging to ...
Sudipta Ponra, Ruzal Sitdikov, Alyssio Calis, Oscar Verho   +3 more
wiley   +1 more source

Ab-initio crystal structure analysis and refinement approaches of oligo p-benzamides based on electron diffraction data [PDF]

, 2012
Ab-initio crystal structure analysis of organic materials from electron diffraction data is presented. The data were collected using the automated electron diffraction tomography (ADT) technique.
Brunklaus, Gunther, Gorelik, Tatiana E., Kilbinger, Andreas F. M., Kolb, Ute, Streek, Jacco van de   +4 more
core   +1 more source

Mannich Reaction of Secondary Benzylzinc Reagents: Synthesis of α,β‐Disubstituted β‐Arylethylamines

Asian Journal of Organic Chemistry, EarlyView.
The organometallic Mannich multicomponent reaction (MCR) of secondary benzylzinc reagents is described. The final α,β‐disubstituted β‐arylethylamines are obtained in generally high yields. The reaction is however characterized by a general lack of diastereoselectivity. A possible explanation is provided.
Baptiste Leroux, Federico Banchini, Olivier Jackowski, Alejandro Perez‐Luna, Fabrice Chemla, Marc Presset, Erwan Le Gall   +6 more
wiley   +1 more source

Crystal structure of 2-(1,3,7,9-tetramethyl-2,4,6,8-tetraoxo-1,2,3,4,6,7,8,9-octahydropyrido[2,3-d:6,5-d′]dipyrimidin-5-yl)benzamide dimethylformamide hemisolvate

Acta Crystallographica Section E, 2014
The title compound, C20H18N6O5·0.5C3H7NO, crystallized as a dimethylformamide (DMF) solvate. In the main molecule, the dihedral angle between the pyridodipyrimidine fused-ring system and the benzamide substituent is 82.26 (11)°.
Armen Ayvazyan
doaj   +1 more source

Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines [PDF]

, 2019
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products.
Arachchige, Pandula T. Kirinde, Yi, Chae S.   +1 more
core   +3 more sources

Production Of 11C‐Labeled Amides Via “In‐Loop” 11C‐Carbonylation

Asian Journal of Organic Chemistry, EarlyView.
The current work utilizes carbon‐11 labelled aroyl dimethylaminopyridinium salts in a two‐step in‐loop carbonylative cross‐coupling reaction of aryl halides with [¹¹C]CO yielding a diverse range of carbon‐11 labelled primary benzamides with good to excellent yields.
Tanpreet Kaur, Xia Shao, Allen F. Brooks, Peter J. H. Scott   +3 more
wiley   +1 more source

2-Anilino-N-methyl-N-phenylbenzamide

Acta Crystallographica Section E, 2009
The title compound, C20H18N2O, is composed of three aromatic rings, the dihedral angles between the phenyl and benzamide rings, and between the benzamide and aniline rings being 59.86 (9) and 46.57 (10)°, respectively.
Da-Bin Qin, Chenglin Zhou, Xing-Xing Yang   +2 more
doaj   +1 more source