Results 81 to 90 of about 16,181 (141)

Proteome‐Wide Profiling of Olaparib Interactors Using a Biotinylated Photoaffinity Probe

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
Novel interactors found for olaparib: Olaparib is an important anti‐cancer drug in BRCA‐mutated cancers. In this study, we identified novel interactors for olaparib using photoaffinity labeling. We designed a biotinylated photoaffinity probe and used it in a proteomic screening to discover a broad range of olaparib interactors, including previously ...
Femke L. A. M. van der Heijden, Suzanne A. Weijers, Onno Bleijerveld, Katarzyna W. Kliza, Michiel Vermeulen, Dmitri V. Filippov   +5 more
wiley   +1 more source

Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy. [PDF]

, 2016
Patient-derived xenograft (PDX) mouse models of cancer are emerging as an important component of personalized precision cancer therapy. However, most models currently offered to patients have their tumors subcutaneously-transplanted in immunodeficient ...
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Ichikawa, Yasushi, Maawy, Ali, Murakami, Takashi, Tanaka, Kuniya, Zhang, Nan, Zhang, Yong   +10 more
core   +2 more sources

Synthesis and Preliminary Evaluation of Tanshinone Mimic Conjugates for Mechanism of Action Studies

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
A small array of Tanshinone Mimics (TM) probes with a detection‐promoting moiety (either a photoaffinity probe ‐ PAP or biotin) has been synthesized for mechanism of action (MoA) studies on Human antigen R (HuR). Biological and biochemical assays were used to characterize the novel TM conjugates.
Giulia Assoni, Ágata Sofia Assunção Carreira, Matteo Tomiello, Pierfausto Seneci, Alessandro Provenzani, Daniela Arosio   +5 more
wiley   +1 more source

A Polyproline type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein‐protein Interaction Implicated in Breast Cancer

ChemBioChem, Accepted Article.
Given the essential role of protein‐protein interactions (PPIs) in cellular signalling pathways their selective modulation is of great therapeutic interest. Mimicry of secondary structural protein elements has emerged as a promising strategy, with various scaffolds reproducing recognition surfaces of α‐helical and β‐strand/sheet proteins.
James Luccarelli, Philip C. Simister, Andrew D. Hamilton, Stephan M. Feller, Sam Thompson   +4 more
wiley   +1 more source

4-Iodo-N-(o-tolylsulfonyl)benzamide

IUCrData, 2017
The title compound, C14H12INO3S, crystallizes with two independent molecules (A and B) in the asymmetric unit. The dihedral angle between the two aryl rings is 83.1 (4)° in molecule A and 79.8 (4)° in molecule B.
S. Naveen, E. Suresha, A. G. Sudha, N. K. Lokanath, P. A. Suchetan, M. Abdoh   +5 more
doaj   +1 more source

para-Selective C-H amidation of simple arenes with nitriles [PDF]

, 2015
A para-selective C-H amidation of simple arenes with nitriles has been developed. By increasing the amount of arenes, a further meta-selective C-H arylation of the produced amides occurred.
Allen, Allen, Antonchick, Casitas, Chen, Fañanás-Mastral, Gao, Grohmann, Guérinot, Harvey, He, He, Hsieh, Huffman, Ichiishi, Ichiishi, Kantak, Kawano, Kim, Kim, King, Li, Li, Louillat, Lv, Marchetti, Matsuda, Nadres, Ng, Ng, Ng, Ng, Peng, Phipps, Phipps, Pialat, Ryu, Ryu, Shai, Shin, Shrestha, Skucas, Sokolovs, Su, Tew, Thomas, Thu, Tran, Tsang, Valeur, Wang, Wang, Wang, Xiang, Xu, Yoo, Zhang, Zhang, Zhang, Zhao   +59 more
core   +2 more sources

Energy Transfer Catalysis Enabled 2,2,2‐Trifluoroethoxy‐Amination of Olefins

ChemistryEurope, EarlyView.
A thioxanthone‐catalyzed 2,2,2‐trifluoroethoxyamination of olefins is developed using unprecedented, easily prepared, and bench‐stable oxime ethers via the generation of alkoxy and iminyl radicals. The controlled intermolecular addition of the alkoxy radical to an olefin, over possible competing side processes, is critical.
Floriane Doche, Thibault Gallavardin, Thomas Poisson, Tatiana Besset   +3 more
wiley   +1 more source

Studies of the Synthesis of Fused Isoxazoline/Isoquinolinones and Evaluation of the Antifungal Activity of Isoxazole-like Benzamide and Isoquinolinone Hybrids

Molecules
Isoxazole derivatives (isoxazoles, isoxazolines, and isoxazolidines) are present in the structure of several natural products and/or pharmaceutically interesting compounds.
Konstantinos A. Ouzounthanasis, Jasmina Glamočlija, Ana Ćirić, Alexandros E. Koumbis   +3 more
doaj   +1 more source

2-Amino-N-(2-chloropyridin-3yl)benzamide

IUCrData, 2017
The title compound, C12H10ClN3O, is a condensation product of 3-amino-2-chloropyridine and ethyl 2-aminobenzoate in which the aromatic rings are almost coplanar [dihedral angle = 2.28 (9)°] and an intramolecular N—H...O hydrogen bond occurs.
Noura M. Riad, Darius P. Zlotos, Ulrike Holzgrabe   +2 more
doaj   +1 more source

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]

, 1983
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M., Godoi, Paulo H., Counago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.   +11 more
core   +3 more sources