Results 1 to 10 of about 6,457 (248)

Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes [PDF]

Biomedicines, 2023
The number of N-Methyl-D-aspartate receptor (NMDAR) linked neurodegenerative diseases such as Alzheimer’s disease and dementia is constantly increasing. This is partly due to demographic change and presents new challenges to societies. To date, there are
Nadine Ritter, Paul Disse, Bernhard Wünsch, Guiscard Seebohm, Nathalie Strutz-Seebohm   +4 more
doaj   +5 more sources

Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines. [PDF]

Org Lett, 2023
The first Pd-catalyzed [5 + 2] rollover annulation of 1-benzylpyrazoles with alkynes to assemble 10H-benzo[e]pyrazolo[1,5-a]azepines (tricyclic 2-benzazepines) has been developed.
Suárez-Lustres A, Martínez-Yáñez N, Velasco-Rubio Á, Varela JA, Saá C.   +4 more
europepmc   +4 more sources

Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangement [PDF]

Nature Communications, 2022
The dearomative functionalization of aromatic compounds represents a challenging transformation, as it typically needs to overcome a great kinetic barrier.
Qiu Shi, Zhehui Liao, Zhili Liu, Jiajia Wen, Chenguang Li, Jiamin He, Jiazhen Deng, Shan Cen, Tongxiang Cao, Jinming Zhou, Shifa Zhu   +10 more
doaj   +3 more sources

Nitrogen atom insertion into arenols to access benzazepines. [PDF]

Chem Sci
Advances in site-selective molecular editing have enabled structural modification on complex molecules.
He Y, Wang J, Zhu T, Zheng Z, Wei H.
europepmc   +6 more sources

Chiral Ligands Based on Binaphthyl Scaffolds for Pd-Catalyzed Enantioselective C-H Activation/Cycloaddition Reactions. [PDF]

J Am Chem Soc, 2022
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/REDES METAL-ORGANICAS PARA LA VALORIZACION DE BIOMASA A TRAVES DE SIMULACIONES DE SISTEMAS CATALITICOSWe report the first examples of the use of ...
González JM, Vidal X, Ortuño MA, Mascareñas JL, Gulías M.   +4 more
europepmc   +3 more sources

Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines [PDF]

Advanced Synthesis and Catalysis, 2020
NOTICE: This is the peer reviewed version of the following article: Velasco-Rubio, A., Varela J. A., Saá C. (2020). Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines. Adv. Synth. Catal., 362, 22, 4861-
Bremner J. B., Carlos Saá, Clayton T., Elgarf A. A., Griffin C. E., Jesús A. Varela, Mantaj J., Meyer A. G., Meyer A. G., Meyer A. G., Pareek A., Ram V. J., Yin P., Álvaro Velasco‐Rubio   +13 more
core   +2 more sources

Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds. [PDF]

RSC Adv, 2020
An efficient and highly diastereoselective synthesis of 2-substituted benzo[b]azepin-5-olviastereocontrolled addition of Grignard reagents to oxa-bridged benzazepines has been developed.
Zhang Y, Bao Q, Zhang N, Wang S, Yu X.
europepmc   +6 more sources

Palladium-Catalyzed [5+2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines [PDF]

Organic Letters, 2020
NOTICE: This is the peer reviewed version of the following article: Velasco-Rubio, A., Varela, J. A., Saá, C. (2020). Palladium-Catalyzed [5+2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines. Org.
Saá Rodríguez, Carlos, Varela Carrete, Jesús Ángel, Velasco Rubio, Álvaro   +2 more
core   +2 more sources

Modern Friedel-Crafts chemistry. Part 35. New synthetic approach to substituted indolo[2,1-a][2]benzazepines and indolo[2,1-a]isoquinolines via Friedel-Crafts cyclialkylations

ARKIVOC, 2012
Hassan A. K. Abd El-Aal, * Ali A. Khalaf, Talaat I. El-Emary   +2 more
doaj   +3 more sources

Unravelling benzazepines and aminopyrimidine as multi-target therapeutic repurposing drugs for EGFR V774M mutation in neuroglioma patients [PDF]

BioImpacts
Introduction: Neuroglioma, a classification encompassing tumors arising from glial cells, exhibits variable aggressiveness and depends on tumor grade and stage.
Jitender Singh, Krishan L Khanduja, Pramod K Avti   +2 more
doaj   +1 more source