Results 1 to 10 of about 3,093 (168)

Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangement [PDF]

Nature Communications, 2022
The dearomative functionalization of aromatic compounds represents a challenging transformation, as it typically needs to overcome a great kinetic barrier.
Qiu Shi, Zhehui Liao, Zhili Liu, Jiajia Wen, Chenguang Li, Jiamin He, Jiazhen Deng, Shan Cen, Tongxiang Cao, Jinming Zhou, Shifa Zhu   +10 more
doaj   +2 more sources

Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes [PDF]

Biomedicines, 2023
The number of N-Methyl-D-aspartate receptor (NMDAR) linked neurodegenerative diseases such as Alzheimer’s disease and dementia is constantly increasing. This is partly due to demographic change and presents new challenges to societies. To date, there are
Nadine Ritter, Paul Disse, Bernhard Wünsch, Guiscard Seebohm, Nathalie Strutz-Seebohm   +4 more
doaj   +2 more sources

Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines. [PDF]

Org Lett, 2023
The first Pd-catalyzed [5 + 2] rollover annulation of 1-benzylpyrazoles with alkynes to assemble 10H-benzo[e]pyrazolo[1,5-a]azepines (tricyclic 2-benzazepines) has been developed.
Suárez-Lustres A, Martínez-Yáñez N, Velasco-Rubio Á, Varela JA, Saá C.   +4 more
europepmc   +3 more sources

Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors

Results in Chemistry, 2022
The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its ...
Sneh Lata, Ashish Dhir, S.V. Kessar, K.N. Singh, S.K. Kulkarni, Pushpinder Singh   +5 more
doaj   +1 more source

Unravelling benzazepines and aminopyrimidine as multi-target therapeutic repurposing drugs for EGFR V774M mutation in neuroglioma patients [PDF]

BioImpacts
Introduction: Neuroglioma, a classification encompassing tumors arising from glial cells, exhibits variable aggressiveness and depends on tumor grade and stage.
Jitender Singh, Krishan L Khanduja, Pramod K Avti   +2 more
doaj   +1 more source

Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compounds, C22H29NO2 (3) and C22H29NO2 (4) [systematic names: (1S*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol and (1R*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol, are
Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch   +3 more
doaj   +1 more source

Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the title compound, C25H27NO4S, which crystallized as a racemate, the relative configuration of the adjacent OH and CH3 groups on the azepine ring is trans. The seven-membered azepin ring has a chair-like conformation. The planar aromatic rings of the
Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch   +3 more
doaj   +1 more source

Convenient Synthesis of 2-Benzazepines via Radical Cyclization [PDF]

The Journal of Organic Chemistry, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Akio, Kamimura, Yohei, Taguchi, Yoji, Omata, Masahiko, Hagihara   +3 more
openaire   +2 more sources

Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds

RSC Advances, 2020
An efficient and highly diastereoselective synthesis of 2-substituted benzo[b]azepin-5-olviastereocontrolled addition of Grignard reagents to oxa-bridged benzazepines has been developed.
Yuewei Zhang, Qingqing Bao, Ning Zhang, Shuohang Wang, Xue Yu   +4 more
openaire   +3 more sources

Asymmetric synthesis of trans-3,4-disubstituted tetrahydro-2-benzazepines

ARKIVOC, 2010
David Dumoulin, Stéphane Lebrun, Axel Couture, Eric Deniau, Pierre Grandclaudon   +4 more
doaj   +1 more source