Results 1 to 10 of about 6,469 (247)

Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes [PDF]

Biomedicines, 2023
The number of N-Methyl-D-aspartate receptor (NMDAR) linked neurodegenerative diseases such as Alzheimer’s disease and dementia is constantly increasing. This is partly due to demographic change and presents new challenges to societies. To date, there are
Nadine Ritter, Paul Disse, Bernhard Wünsch, Guiscard Seebohm, Nathalie Strutz-Seebohm   +4 more
doaj   +5 more sources

Nitrogen atom insertion into arenols to access benzazepines. [PDF]

Chem Sci
Advances in site-selective molecular editing have enabled structural modification on complex molecules. However, thus far, their applications have been restricted to C–H functionalization chemistry.
He Y, Wang J, Zhu T, Zheng Z, Wei H.
europepmc   +6 more sources

Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangement [PDF]

Nature Communications, 2022
The dearomative functionalization of aromatic compounds represents a challenging transformation, as it typically needs to overcome a great kinetic barrier.
Qiu Shi, Zhehui Liao, Zhili Liu, Jiajia Wen, Chenguang Li, Jiamin He, Jiazhen Deng, Shan Cen, Tongxiang Cao, Jinming Zhou, Shifa Zhu   +10 more
doaj   +3 more sources

Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines. [PDF]

Org Lett, 2023
The first Pd-catalyzed [5 + 2] rollover annulation of 1-benzylpyrazoles with alkynes to assemble 10H-benzo[e]pyrazolo[1,5-a]azepines (tricyclic 2-benzazepines) has been developed.
Suárez-Lustres A, Martínez-Yáñez N, Velasco-Rubio Á, Varela JA, Saá C.   +4 more
europepmc   +4 more sources

Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines [PDF]

Advanced Synthesis and Catalysis, 2020
NOTICE: This is the peer reviewed version of the following article: Velasco-Rubio, A., Varela J. A., Saá C. (2020). Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines. Adv. Synth. Catal., 362, 22, 4861-
Bremner J. B., Carlos Saá, Clayton T., Elgarf A. A., Griffin C. E., Jesús A. Varela, Mantaj J., Meyer A. G., Meyer A. G., Meyer A. G., Pareek A., Ram V. J., Yin P., Álvaro Velasco‐Rubio   +13 more
core   +2 more sources

Chiral Ligands Based on Binaphthyl Scaffolds for Pd-Catalyzed Enantioselective C-H Activation/Cycloaddition Reactions. [PDF]

J Am Chem Soc, 2022
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/REDES METAL-ORGANICAS PARA LA VALORIZACION DE BIOMASA A TRAVES DE SIMULACIONES DE SISTEMAS CATALITICOSWe report the first examples of the use of ...
González JM, Vidal X, Ortuño MA, Mascareñas JL, Gulías M.   +4 more
europepmc   +3 more sources

From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds

ACS Central Science, 2019
Inherently complex, lignin-derived aromatic monomers comprising valuable structural moieties present in many pharmaceuticals would serve as ideal substrates for the construction of biologically active molecules.
Saravanakumar Elangovan, Anastasiia Afanasenko, Jörg Haupenthal, Zhuohua Sun, Yongzhuang Liu, Anna K. H. Hirsch, Katalin Barta   +6 more
doaj   +2 more sources

Assembly of Tetrahydroquinolines and 2-Benzazepines by Pd-Catalyzed Cycloadditions Involving the Activation of C(sp³)-H Bonds. [PDF]

Org Lett, 2021
Cycloaddition reactions are among the most practical strategies to assemble cyclic products; however, they usually require the presence of reactive functional groups in the reactants.
Vidal X, Mascareñas JL, Gulías M.
europepmc   +2 more sources

Palladium-Catalyzed [5+2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines [PDF]

Organic Letters, 2020
NOTICE: This is the peer reviewed version of the following article: Velasco-Rubio, A., Varela, J. A., Saá, C. (2020). Palladium-Catalyzed [5+2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines. Org.
Saá Rodríguez, Carlos, Varela Carrete, Jesús Ángel, Velasco Rubio, Álvaro   +2 more
core   +2 more sources

One-Pot, Water-Mediated, H2O2-HCl Catalyzed Synthesis of Benzazepines

, 2020
One-pot, multicomponent H2O2-HCl catalyzed system was employed for the synthesis of a series of benzazepine compounds. The implemented procedure oxidized the carbon-nitrogen bonds and produced benzazepines, while integrating diamines and substituted ...
Nidhi Singh, Jaya Pandey
openalex   +2 more sources