Results 1 to 10 of about 4,292 (206)

Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds. [PDF]

RSC Adv, 2020
An efficient and highly diastereoselective synthesis of 2-substituted benzo[b]azepin-5-olviastereocontrolled addition of Grignard reagents to oxa-bridged benzazepines has been developed.
Zhang Y, Bao Q, Zhang N, Wang S, Yu X.
europepmc   +6 more sources

Nitrogen atom insertion into arenols to access benzazepines. [PDF]

Chem Sci
Advances in site-selective molecular editing have enabled structural modification on complex molecules.
He Y, Wang J, Zhu T, Zheng Z, Wei H.
europepmc   +5 more sources

Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines. [PDF]

Org Lett, 2023
The first Pd-catalyzed [5 + 2] rollover annulation of 1-benzylpyrazoles with alkynes to assemble 10H-benzo[e]pyrazolo[1,5-a]azepines (tricyclic 2-benzazepines) has been developed.
Suárez-Lustres A, Martínez-Yáñez N, Velasco-Rubio Á, Varela JA, Saá C.   +4 more
europepmc   +3 more sources

Chiral Ligands Based on Binaphthyl Scaffolds for Pd-Catalyzed Enantioselective C-H Activation/Cycloaddition Reactions. [PDF]

J Am Chem Soc, 2022
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/REDES METAL-ORGANICAS PARA LA VALORIZACION DE BIOMASA A TRAVES DE SIMULACIONES DE SISTEMAS CATALITICOSWe report the first examples of the use of ...
González JM, Vidal X, Ortuño MA, Mascareñas JL, Gulías M.   +4 more
europepmc   +3 more sources

Iodine(III)-Mediated Oxidation of Anilines to Construct Dibenzazepines. [PDF]

Chemistry, 2023
Cyclization: A mild, room temperature oxidative cyclization of 2‐substituted anilines that accesses a broad range of medium‐ring N‐heterocycles via radical intermediates is reported. Abstract The development of an efficient process that produces bioactive medium‐sized N‐heterocyclic scaffolds from 2‐substituted anilines using either iodosobenzene or ...
White CM, Zorigt N, Deng T, Driver TG.
europepmc   +2 more sources

Review on allosteric modulators of dopamine receptors so far. [PDF]

Health Sci Rep
Abstract Background Contemporary research is predominantly directed towards allosteric modulators, a class of compounds designed to interact with specific sites distinct from the orthosteric site on G protein‐coupled receptors. These allosteric modulators play a pivotal role in influencing diverse pharmacological effects, such as agonism/inverse ...
Girmaw F.
europepmc   +2 more sources

Propargyl Amines: Versatile Building Blocks in Post-Ugi Transformations. [PDF]

ChemistryOpen, 2023
Applications of propargyl amines in the Ugi reaction and further transformations are discussed in this review. These post‐Ugi transformations, employing transition metal catalysis, base‐mediated reactions and rearrangements, allow the syntheses of diversely substituted scaffolds.
Bhoraniya RB, Modha SG.
europepmc   +2 more sources

Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines [PDF]

, 2020
NOTICE: This is the peer reviewed version of the following article: Velasco-Rubio, A., Varela J. A., Saá C. (2020). Recent Advances in Transition-Metal Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines. Adv. Synth. Catal., 362, 22, 4861-
Bremner J. B., Carlos Saá, Clayton T., Elgarf A. A., Griffin C. E., Jesús A. Varela, Mantaj J., Meyer A. G., Meyer A. G., Meyer A. G., Pareek A., Ram V. J., Yin P., Álvaro Velasco‐Rubio   +13 more
core   +1 more source

Synthesis of Indole‐Fused 1,4‐Diazepinones via Photoredox‐Catalyzed Cascade Cyclization Reaction

Advanced Synthesis &Catalysis, Volume 365, Issue 22, Page 3958-3966, November 21, 2023., 2023
Abstract A photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐a]indol‐6(7H)‐ones starting from N‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric ...
Elisa Brambilla, Silvia Meraviglia, Edoardo Moneta, Donatella Nava, Silvia Rizzato, Giorgio Abbiati, Valentina Pirovano   +6 more
wiley   +1 more source

Asymmetric Catalytic Transformations of Aza‐ortho‐ and Aza‐para‐Quinone Methides

ChemCatChem, Volume 15, Issue 13, July 7, 2023., 2023
Aza‐quinone methides (aza‐QMs) are transient intermediates, which are able to react easily with a variety of nucleophiles providing a variety of N‐heterocycles. The catalytic methodologies for the derivatization of aza‐QM into chiral derivatives have been recently reported and involve organocatalytic or organometallic approaches.
Mercedes Zurro, Aitor Maestro
wiley   +1 more source