Results 11 to 20 of about 6,457 (248)

Catalytic Cyclization of o‐Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3‐Benzazepines [PDF]

Angewandte Chemie, 2015
NOTICE: This is the peer reviewed version of the following article: Álvarez-Pérez, A., González-Rodríguez, C., García-Yebra, C., Varela, J. A., Oñate, E., Esteruelas, M. A., Saá, C. (2015).
Esteruelas Rodrigo, Miguel Ángel, García Yebra, Cristina, González Rodríguez, Carlos, Oñate Rodríguez, Enrique, Saá Rodríguez, Carlos, Varela Carrete, Jesús Ángel, Álvarez Pérez, Andrea   +6 more
core   +2 more sources

From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds

ACS Central Science, 2019
Inherently complex, lignin-derived aromatic monomers comprising valuable structural moieties present in many pharmaceuticals would serve as ideal substrates for the construction of biologically active molecules.
Saravanakumar Elangovan, Anastasiia Afanasenko, Jörg Haupenthal, Zhuohua Sun, Yongzhuang Liu, Anna K. H. Hirsch, Katalin Barta   +6 more
doaj   +2 more sources

Iodine(III)-Mediated Oxidation of Anilines to Construct Dibenzazepines. [PDF]

Chemistry, 2023
Cyclization: A mild, room temperature oxidative cyclization of 2‐substituted anilines that accesses a broad range of medium‐ring N‐heterocycles via radical intermediates is reported. Abstract The development of an efficient process that produces bioactive medium‐sized N‐heterocyclic scaffolds from 2‐substituted anilines using either iodosobenzene or ...
White CM, Zorigt N, Deng T, Driver TG.
europepmc   +2 more sources

Preparation of substituted tetrahydro-1-benzazepines by lithiation-trapping [PDF]

Annalen der Pharmacie, 2018
The tetrahydro‐1‐benzazepine or benzo[b]azepine ring system is found in a number of drug molecules although methods to access 2,2‐disubstituted derivatives are rare. Here we report the preparation of N‐tert‐butoxycarbonyl‐2‐phenyltetrahydro‐1‐benzazepine
Aeyad, Ahlbrecht, Andersson, Beak, Bertini Gross, Blanco, Carter, Chaumontet, chemistry, Cochrane, Cochrane, Coldham, Coldham, Davidson, Gómez-Ayala, Hino, Kessar, Konstam, Li, Li, Liang, Madan, Maryanoff, Mealing, Meyers, Min, Miyata, Rahman, Raj, Robinson, Rueping, Sheikh, Singh, Soto, Stead, Talk, Tatic, Wang, Wu   +38 more
core   +2 more sources

One-Pot, Water-Mediated, H2O2-HCl Catalyzed Synthesis of Benzazepines

, 2020
One-pot, multicomponent H2O2-HCl catalyzed system was employed for the synthesis of a series of benzazepine compounds. The implemented procedure oxidized the carbon-nitrogen bonds and produced benzazepines, while integrating diamines and substituted ...
Nidhi Singh, Jaya Pandey
openalex   +2 more sources

Review on allosteric modulators of dopamine receptors so far. [PDF]

Health Sci Rep
Abstract Background Contemporary research is predominantly directed towards allosteric modulators, a class of compounds designed to interact with specific sites distinct from the orthosteric site on G protein‐coupled receptors. These allosteric modulators play a pivotal role in influencing diverse pharmacological effects, such as agonism/inverse ...
Girmaw F.
europepmc   +2 more sources

Propargyl Amines: Versatile Building Blocks in Post-Ugi Transformations. [PDF]

ChemistryOpen, 2023
Applications of propargyl amines in the Ugi reaction and further transformations are discussed in this review. These post‐Ugi transformations, employing transition metal catalysis, base‐mediated reactions and rearrangements, allow the syntheses of diversely substituted scaffolds.
Bhoraniya RB, Modha SG.
europepmc   +2 more sources

Heck–Suzuki Tandem Reaction for the Synthesis of 3-Benzazepines [PDF]

Journal of Organic Chemistry, 2015
A novel procedure for the Heck-Suzuki tandem reaction suitable for the construction of nitrogen-containing medium rings was developed to provide access toward the 3-benzazepine framework.
Anatoly A. Peshkov, Vsevolod A. Peshkov, Olga P. Pereshivko, Kristof Van Hecke, Rakesh Kumar, Erik V. Van der Eycken   +5 more
openalex   +2 more sources

Convenient Synthesis of 2‐Benzazepines via Radical Cyclization. [PDF]

The Journal of Organic Chemistry, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Akio Kamimura, Yohei Taguchi, Yoji Omata, Masahiko Hagihara   +3 more
openalex   +5 more sources

Assembly of Tetrahydroquinolines and 2-Benzazepines by Pd-Catalyzed Cycloadditions Involving the Activation of C(sp3)–H Bonds

Organic Letters, 2021
Cycloaddition reactions are among the most practical strategies to assemble cyclic products; however, they usually require the presence of reactive functional groups in the reactants.
Xandro Vidal, J. Mascareñas, Moisés Gulías   +2 more
semanticscholar   +1 more source