Results 11 to 20 of about 4,292 (206)
Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes. [PDF]
Biomedicines, 2023 The number of N-Methyl-D-aspartate receptor (NMDAR) linked neurodegenerative diseases such as Alzheimer’s disease and dementia is constantly increasing. This is partly due to demographic change and presents new challenges to societies. To date, there are
Ritter N +4 more
europepmc +4 more sources
Heck–Suzuki Tandem Reaction for the Synthesis of 3-Benzazepines [PDF]
The Journal of Organic Chemistry, 2015 AbstractThe microwave‐assisted title reaction between N‐protected 2‐(2‐bromoaryl)alkylpropargylamides and organo‐boron compounds gives the corresponding 3‐benzazepin‐2‐ones.
Peshkov, Anatoly A. +5 more
openaire +5 more sources
Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangement. [PDF]
Nat Commun, 2022 The dearomative functionalization of aromatic compounds represents a challenging transformation, as it typically needs to overcome a great kinetic barrier.
Shi Q +10 more
europepmc +2 more sources
Convenient Synthesis of 2-Benzazepines via Radical Cyclization [PDF]
The Journal of Organic Chemistry, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Masahiko Hagihara +3 more
openaire +5 more sources
Carbotrifluoromethylations of C−C Multiple Bonds (Excluding Aryl‐ and Alkynyltrifluoromethylations)
Chemistry – A European Journal, Volume 29, Issue 19, April 3, 2023., 2023 One main method for the access of organofluorine compounds is the trifluoromethylative functionalization of an olefin bond, which simultaneously introduces a functional group and a trifluoromethyl element into an olefin framework. This review provides a concise overview of this powerful and versatile method. Abstract Organofluorine chemistry has become
Klára Aradi, Loránd Kiss
wiley +1 more source
Synthesizing Strained Azatriseptane Frameworks
Helvetica Chimica Acta, Volume 106, Issue 4, April 2023., 2023 Abstract Embedding seven‐membered rings into polycyclic aromatic molecules is attractive as they can exert an influence on molecular conformation that ultimately changes the solubility and π‐electronics. The considerations in designing and synthesizing a highly strained azatriseptane framework are discussed herein.
Kai Zhang +3 more
wiley +1 more source
Palladium-Catalyzed [5+2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines [PDF]
, 2020 NOTICE: This is the peer reviewed version of the following article: Velasco-Rubio, A., Varela, J. A., Saá, C. (2020). Palladium-Catalyzed [5+2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines. Org.
Saá Rodríguez, Carlos +2 more
core +1 more source
Pharmacology Research &Perspectives, Volume 11, Issue 2, April 2023., 2023 Dopamine D1 receptor manipulation induced BOLD signal changes in anesthetized rat brain which detected using pharmacological functional MRI. D1‐like receptor agonist increased, while the antagonist decreased the BOLD signal intensity in the striatum, thalamus, and cerebellum.
Yuka Kimura +5 more
wiley +1 more source
Archiv der Pharmazie, Volume 355, Issue 11, November 2022., 2022 To increase the affinity to the N‐methyl‐ d‐aspartate receptors with GluN2B subunit, the phenol of the benzazepine‐based inhibitor WMS‐1410 was replaced bioisosterically by a benzoxazolone moiety and the phenylbutyl side chain was conformationally restricted in a phenylcyclohexyl substituent.
Alexander Markus +8 more
wiley +1 more source