Results 11 to 20 of about 4,384 (210)

Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangement [PDF]

Nature Communications, 2022
The dearomative functionalization of aromatic compounds represents a challenging transformation, as it typically needs to overcome a great kinetic barrier.
Qiu Shi, Zhehui Liao, Zhili Liu, Jiajia Wen, Chenguang Li, Jiamin He, Jiazhen Deng, Shan Cen, Tongxiang Cao, Jinming Zhou, Shifa Zhu   +10 more
doaj   +4 more sources

Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors

Results in Chemistry, 2022
The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its ...
Sneh Lata, Ashish Dhir, S.V. Kessar, K.N. Singh, S.K. Kulkarni, Pushpinder Singh   +5 more
doaj   +2 more sources

Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes [PDF]

Biomedicines, 2023
The number of N-Methyl-D-aspartate receptor (NMDAR) linked neurodegenerative diseases such as Alzheimer’s disease and dementia is constantly increasing. This is partly due to demographic change and presents new challenges to societies. To date, there are
Nadine Ritter, Paul Disse, Bernhard Wünsch, Guiscard Seebohm, Nathalie Strutz-Seebohm   +4 more
doaj   +2 more sources

Palladium-Catalyzed [5 + 2] Rollover Annulation of 1-Benzylpyrazoles with Alkynes: A Direct Entry to Tricyclic 2-Benzazepines. [PDF]

Org Lett, 2023
The first Pd-catalyzed [5 + 2] rollover annulation of 1-benzylpyrazoles with alkynes to assemble 10H-benzo[e]pyrazolo[1,5-a]azepines (tricyclic 2-benzazepines) has been developed.
Suárez-Lustres A, Martínez-Yáñez N, Velasco-Rubio Á, Varela JA, Saá C.   +4 more
europepmc   +3 more sources

Chiral Ligands Based on Binaphthyl Scaffolds for Pd-Catalyzed Enantioselective C-H Activation/Cycloaddition Reactions. [PDF]

J Am Chem Soc, 2022
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/REDES METAL-ORGANICAS PARA LA VALORIZACION DE BIOMASA A TRAVES DE SIMULACIONES DE SISTEMAS CATALITICOSWe report the first examples of the use of ...
González JM, Vidal X, Ortuño MA, Mascareñas JL, Gulías M.   +4 more
europepmc   +3 more sources

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy [PDF]

, 2010
The synthesis of ruthenium(II) and osmium(II) arene complexes with the closely related indolo[3,2-c]quinolines N-(11H-indolo[3,2-c]quinolin-6-yl)-ethane-1,2-diamine (L1) and N′-(11H-indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (L2) and ...
A Dobrov, A Dorcier, AFA Peacock, AK Renfrew, Bernhard K. Keppler, BJ Lipworth, C Berthet, C Lamazzi, C McInnes, C Schultz, C-M Chien, CA Vock, CC Tzeng, CH Nguyen, CT Alabaster, CT Alabaster, D Marko, DW Zaharewitz, EK Rowinsky, F Wang, Gerhard Mühlgassner, H Chen, HB MacPhillamy, HH Sedlacek, J Bergman, J Zagermann, Lukas K. Filak, M Tominaga, Michael A. Jakupec, MW Karaman, N Pagano, P Heffeter, P Molina, Petra Heffeter, RC Donehower, RE Morris, S-H Yang, T Fujioka, T Nishi, T Nishi, T Schmeller, Vladimir B. Arion, W Ginzinger, W Kiel, W Stadlbauer, W Stadlbauer, Walter Berger, WF Schmid, WF Schmid, WF Schmid, X-W Hu, Y-L Chen, YNV Gopal   +52 more
core   +4 more sources

Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds. [PDF]

RSC Adv, 2020
An efficient and highly diastereoselective synthesis of 2-substituted benzo[b]azepin-5-olviastereocontrolled addition of Grignard reagents to oxa-bridged benzazepines has been developed.
Zhang Y, Bao Q, Zhang N, Wang S, Yu X.
europepmc   +4 more sources

Synthesis of Chiral Tetrahydro-3-benzazepine Motifs by Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Ene-carbamates. [PDF]

Org Lett, 2022
Peters BBC, Andersson PG, Ruchirawat S, Ieawsuwan W.   +3 more
europepmc   +2 more sources

Asymmetric synthesis of trans-3,4-disubstituted tetrahydro-2-benzazepines

ARKIVOC, 2010
David Dumoulin, Stéphane Lebrun, Axel Couture, Eric Deniau, Pierre Grandclaudon   +4 more
doaj   +3 more sources

Synthesis of Indole‐Fused 1,4‐Diazepinones via Photoredox‐Catalyzed Cascade Cyclization Reaction

Advanced Synthesis &Catalysis, Volume 365, Issue 22, Page 3958-3966, November 21, 2023., 2023
Abstract A photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐a]indol‐6(7H)‐ones starting from N‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric ...
Elisa Brambilla, Silvia Meraviglia, Edoardo Moneta, Donatella Nava, Silvia Rizzato, Giorgio Abbiati, Valentina Pirovano   +6 more
wiley   +1 more source