Results 21 to 30 of about 4,292 (206)

Phenol—Benzoxazolone bioisosteres: Synthesis and biological evaluation of tricyclic GluN2B‐selective N‐methyl‐ d‐aspartate receptor antagonists

Archiv der Pharmazie, Volume 355, Issue 9, September 2022., 2022
Tricyclic tetrahydrooxazolo[4,5‐h]‐[3]benzazepin‐9‐ols 22 were designed as phenol bioisosteres of tetrahydro‐3‐benzazepine‐1,7‐diols. In receptor binding studies, ketone 22m showed the highest affinity toward GluN2B subunit‐containing N‐methyl‐ d‐aspartate receptors.
Alexander Markus, Julian A. Schreiber, Gunnar Goerges, Bastian Frehland, Guiscard Seebohm, Dirk Schepmann, Bernhard Wünsch   +6 more
wiley   +1 more source

Unravelling benzazepines and aminopyrimidine as multi-target therapeutic repurposing drugs for EGFR V774M mutation in neuroglioma patients [PDF]

BioImpacts
Introduction: Neuroglioma, a classification encompassing tumors arising from glial cells, exhibits variable aggressiveness and depends on tumor grade and stage.
Jitender Singh, Krishan L Khanduja, Pramod K Avti   +2 more
doaj   +1 more source

Pharmaceutically relevant (hetero)cyclic compounds and natural products from lignin-derived monomers:Present and perspectives [PDF]

, 2021
Lignin, the richest source of renewable aromatics on the planet, is an intriguing raw material for the construction of value-added aromatics. In the past decade, much progress has been made regarding the development of efficient lignin depolymerization ...
Afanasenko, Anastasiia, Barta, Katalin
core   +1 more source

Catalytic Cyclization of o‐Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3‐Benzazepines [PDF]

, 2015
NOTICE: This is the peer reviewed version of the following article: Álvarez-Pérez, A., González-Rodríguez, C., García-Yebra, C., Varela, J. A., Oñate, E., Esteruelas, M. A., Saá, C. (2015).
Esteruelas Rodrigo, Miguel Ángel, García Yebra, Cristina, González Rodríguez, Carlos, Oñate Rodríguez, Enrique, Saá Rodríguez, Carlos, Varela Carrete, Jesús Ángel, Álvarez Pérez, Andrea   +6 more
core   +1 more source

Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compounds, C22H29NO2 (3) and C22H29NO2 (4) [systematic names: (1S*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol and (1R*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol, are
Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch   +3 more
doaj   +1 more source

Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors

Results in Chemistry, 2022
The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its ...
Sneh Lata, Ashish Dhir, S.V. Kessar, K.N. Singh, S.K. Kulkarni, Pushpinder Singh   +5 more
doaj  

Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the title compound, C25H27NO4S, which crystallized as a racemate, the relative configuration of the adjacent OH and CH3 groups on the azepine ring is trans. The seven-membered azepin ring has a chair-like conformation. The planar aromatic rings of the
Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch   +3 more
doaj   +1 more source

A suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst [PDF]

, 2010
The preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines, N-sulfonyl-2,3,4,5-tetrahydro-1H-2-benzazepines and N-sulfonyl-1,2,3,4,5,6-hexahydrobenzazocine was catalyzed by a Preyssler heteropolyacid, H₁₄[NaP₅W₃₀O₁₁₀], (PA), supported on silica ...
Autino, Juan Carlos, Giaccio, Héctor E., Romanelli, Gustavo Pablo, Ruiz, Diego Manuel   +3 more
core   +3 more sources

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy [PDF]

, 2010
The synthesis of ruthenium(II) and osmium(II) arene complexes with the closely related indolo[3,2-c]quinolines N-(11H-indolo[3,2-c]quinolin-6-yl)-ethane-1,2-diamine (L1) and N′-(11H-indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (L2) and ...
A Dobrov, A Dorcier, AFA Peacock, AK Renfrew, Bernhard K. Keppler, BJ Lipworth, C Berthet, C Lamazzi, C McInnes, C Schultz, C-M Chien, CA Vock, CC Tzeng, CH Nguyen, CT Alabaster, CT Alabaster, D Marko, DW Zaharewitz, EK Rowinsky, F Wang, Gerhard Mühlgassner, H Chen, HB MacPhillamy, HH Sedlacek, J Bergman, J Zagermann, Lukas K. Filak, M Tominaga, Michael A. Jakupec, MW Karaman, N Pagano, P Heffeter, P Molina, Petra Heffeter, RC Donehower, RE Morris, S-H Yang, T Fujioka, T Nishi, T Nishi, T Schmeller, Vladimir B. Arion, W Ginzinger, W Kiel, W Stadlbauer, W Stadlbauer, Walter Berger, WF Schmid, WF Schmid, WF Schmid, X-W Hu, Y-L Chen, YNV Gopal   +52 more
core   +2 more sources

Fe‐Catalyzed α‐C(sp3)−H Amination of N‐Heterocycles

Angewandte Chemie, Volume 137, Issue 5, January 27, 2025.
An iron(II)‐catalyzed α‐selective C−H amination of N‐heterocycles is reported. It employs the N‐heterocycle as the limiting reagent and presumably involves the formation of a reactive Fe‐nitrene/imidyl radical species. This operationally simple method is amenable to the late‐stage functionalization of natural products and APIs.
Andrea Geraci, Olivier Baudoin
wiley   +2 more sources