Results 21 to 30 of about 6,457 (248)

Recent Advances in the Development of Catalytic Methods that Construct Medium-Ring Lactams, Partially Saturated Benzazepines and Their Derivatives

Synthesis, 2021
Recent catalytic methods to construct medium-sized lactams and partially saturated benzazepines and their derivatives are surveyed. The review is divided into the following sections: 1 Introduction 2 Non-Transition-Metal-Catalyzed Reactions 2.1 Beckmann ...
T. Driver, Wrickban Mazumdar
semanticscholar   +1 more source

Some derivatives of 1-benzazepine [PDF]

Canadian Journal of Chemistry, 1969
A new rearrangement of a substituted 5H-1-benzazepine-5-one is described. A new route to certain dimethyl-1-benzazepines has been developed and linked up with a known synthesis. Several new derivatives of 1-benzazepine are reported.
A. H. REES, K. Simon
openalex   +3 more sources

Synthesis of Indole‐Fused 1,4‐Diazepinones via Photoredox‐Catalyzed Cascade Cyclization Reaction

Advanced Synthesis &Catalysis, Volume 365, Issue 22, Page 3958-3966, November 21, 2023., 2023
Abstract A photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐a]indol‐6(7H)‐ones starting from N‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric ...
Elisa Brambilla, Silvia Meraviglia, Edoardo Moneta, Donatella Nava, Silvia Rizzato, Giorgio Abbiati, Valentina Pirovano   +6 more
wiley   +1 more source

Asymmetric Catalytic Transformations of Aza‐ortho‐ and Aza‐para‐Quinone Methides

ChemCatChem, Volume 15, Issue 13, July 7, 2023., 2023
Aza‐quinone methides (aza‐QMs) are transient intermediates, which are able to react easily with a variety of nucleophiles providing a variety of N‐heterocycles. The catalytic methodologies for the derivatization of aza‐QM into chiral derivatives have been recently reported and involve organocatalytic or organometallic approaches.
Mercedes Zurro, Aitor Maestro
wiley   +1 more source

Carbotrifluoromethylations of C−C Multiple Bonds (Excluding Aryl‐ and Alkynyltrifluoromethylations)

Chemistry – A European Journal, Volume 29, Issue 19, April 3, 2023., 2023
One main method for the access of organofluorine compounds is the trifluoromethylative functionalization of an olefin bond, which simultaneously introduces a functional group and a trifluoromethyl element into an olefin framework. This review provides a concise overview of this powerful and versatile method. Abstract Organofluorine chemistry has become
Klára Aradi, Loránd Kiss
wiley   +1 more source

Synthesizing Strained Azatriseptane Frameworks

Helvetica Chimica Acta, Volume 106, Issue 4, April 2023., 2023
Abstract Embedding seven‐membered rings into polycyclic aromatic molecules is attractive as they can exert an influence on molecular conformation that ultimately changes the solubility and π‐electronics. The considerations in designing and synthesizing a highly strained azatriseptane framework are discussed herein.
Kai Zhang, Mélissa El Bitar Nehme, Philip A. Hope, Michel Rickhaus   +3 more
wiley   +1 more source

Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compounds, C22H29NO2 (3) and C22H29NO2 (4) [systematic names: (1S*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol and (1R*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol, are
Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch   +3 more
doaj   +1 more source

Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors

Results in Chemistry, 2022
The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its ...
Sneh Lata, Ashish Dhir, S.V. Kessar, K.N. Singh, S.K. Kulkarni, Pushpinder Singh   +5 more
doaj  

Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the title compound, C25H27NO4S, which crystallized as a racemate, the relative configuration of the adjacent OH and CH3 groups on the azepine ring is trans. The seven-membered azepin ring has a chair-like conformation. The planar aromatic rings of the
Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch   +3 more
doaj   +1 more source

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy [PDF]

, 2010
The synthesis of ruthenium(II) and osmium(II) arene complexes with the closely related indolo[3,2-c]quinolines N-(11H-indolo[3,2-c]quinolin-6-yl)-ethane-1,2-diamine (L1) and N′-(11H-indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (L2) and ...
A Dobrov, A Dorcier, AFA Peacock, AK Renfrew, Bernhard K. Keppler, BJ Lipworth, C Berthet, C Lamazzi, C McInnes, C Schultz, C-M Chien, CA Vock, CC Tzeng, CH Nguyen, CT Alabaster, CT Alabaster, D Marko, DW Zaharewitz, EK Rowinsky, F Wang, Gerhard Mühlgassner, H Chen, HB MacPhillamy, HH Sedlacek, J Bergman, J Zagermann, Lukas K. Filak, M Tominaga, Michael A. Jakupec, MW Karaman, N Pagano, P Heffeter, P Molina, Petra Heffeter, RC Donehower, RE Morris, S-H Yang, T Fujioka, T Nishi, T Nishi, T Schmeller, Vladimir B. Arion, W Ginzinger, W Kiel, W Stadlbauer, W Stadlbauer, Walter Berger, WF Schmid, WF Schmid, WF Schmid, X-W Hu, Y-L Chen, YNV Gopal   +52 more
core   +2 more sources