Results 41 to 50 of about 4,384 (210)

Palladium-Catalyzed [5+2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines [PDF]

, 2020
NOTICE: This is the peer reviewed version of the following article: Velasco-Rubio, A., Varela, J. A., Saá, C. (2020). Palladium-Catalyzed [5+2] Heteroannulation of Phenethylamides with 1,3-Dienes to Dopaminergic 3-Benzazepines. Org.
Saá Rodríguez, Carlos, Varela Carrete, Jesús Ángel, Velasco Rubio, Álvaro   +2 more
core   +1 more source

Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines [PDF]

, 2017
The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. In particular, the tetrahydro-1H-[
Díaz, Amelia, Lucena-Serrano, Ana, Lucena-Serrano, Cristina, López-Romero, Juan Manuel, Valpuesta-Fernandez, Maria   +4 more
core  

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, Volume 25, Issue 12, December 2025.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas

Angewandte Chemie, Volume 136, Issue 12, March 18, 2024.
Asymmetric deprotonation of N‐benzyl urea derivatives of nitrogen heterocycles leads to enantioselective insertion of the benzylic substituent into an aromatic C−N bond. Treatment of the ring‐expanded products induces a stereospecific ring‐contraction that results in an overall asymmetric enantioselective one‐carbon enlargement of the heterocycle ...
Rajendra K. Mallick, Matej Žabka, Jonathan Clayden   +2 more
wiley   +2 more sources

Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors [PDF]

, 2016
The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist.
Contreras-Cáceres, Rafael, Díaz, Amelia, Lucena-Serrano, Cristina, López-Romero, Juan Manuel, Rivera-Ramirez, Alicia, Valpuesta-Fernandez, Maria   +5 more
core  

Multistep Reactions Initiated by Amine‐Based Organometallic Methods

European Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.
The advent of C–H activation and other organometallic methodologies making use of transient directing groups or free amines themselves for the elaboration of amine substrates provides unique access to cascade‐type reactions that can generate significant molecular complexity in one pot. The pursuit of atom‐ and step‐economical pathways to access complex
Victoria D. Ho, Olutayo N. Farinde, Kendra K. Shrestha, Michael C. Young   +3 more
wiley   +1 more source

Study and characterization of modified silicon surfaces with organic molecules [PDF]

, 2016
Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows specific interactions with ...
Contreras-Cáceres, Rafael, Díaz, Amelia, Lucena-Serrano, Ana, López-Romero, Juan Manuel, Sánchez-Molina, María, Valpuesta-Fernandez, Maria   +5 more
core  

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase [PDF]

, 2015
Objectives (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H37Rv. A biomimetic approach for the chemical synthesis of a wide array of 1-
Angell, R, Barrera, DA, Bhakta, S, Cuca, LE, Davies, HM, Evangelopoulos, D, Gershater, MC, Guzman, JD, Hailes, HC, Lamming, ED, Maitra, A, McMahon, E, Mortazavi, PN, Munshi, T, Needham, D, Pesnot, T, Redmond, JM, Ward, JM   +17 more
core   +1 more source

Advances in Ligand‐Driven Pd‐Catalyzed C─H Functionalizations: Recent Insights and Updates

ChemCatChem, Volume 17, Issue 15, August 7, 2025.
The most significant advances in ligand‐driven Pd‐catalyzed organic synthesis over the past two years are presented. Processes involving C─H activation of substrates, avoiding their prefunctionalization are illustrated. Both the activity and selectivity of the catalyst depend on the design of the ligands (pyridones, pyridines, amino acids, phosphines ...
Jesús Moradell, Cosmina Bohan, Alexandra Pop, Esteban P. Urriolabeitia   +3 more
wiley   +1 more source

Convenient Synthesis of 2-Benzazepines via Radical Cyclization [PDF]

The Journal of Organic Chemistry, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Akio, Kamimura, Yohei, Taguchi, Yoji, Omata, Masahiko, Hagihara   +3 more
openaire   +2 more sources