Results 61 to 70 of about 6,457 (248)

Shedding Light on the D1‐Like Receptors: A Fluorescence‐Based Toolbox for Visualization of the D1 and D5 Receptors**

ChemBioChem, Volume 25, Issue 2, January 15, 2024.
We herein report the identification of UR‐NR435 (25), a SCH‐23390‐based fluorescent ligand bearing a 5‐TAMRA dye, as suitable for fluorescence microscopy at the D1R. Single‐digit nanomolar binding affinity could be determined in radioligand competition binding and molecular brightness studies at D1‐like receptors.
Niklas Rosier, Denise Mönnich, Martin Nagl, Hannes Schihada, Alexei Sirbu, Nergis Konar, Irene Reyes‐Resina, Gemma Navarro, Rafael Franco, Peter Kolb, Paolo Annibale, Steffen Pockes   +11 more
wiley   +1 more source

Seven-membered Rings Through Metal-free Rearrangement Mediated By Hypervalent Iodine. [PDF]

, 2015
A versatile and metal-free approach for the synthesis of carbocycles and of heterocycles bearing seven- and eight-membered rings is described. The strategy is based on ring expansion of 1-vinylcycloalkanols (or the corresponding silyl or methyl ether ...
de Carvalho, João Ernesto, Ruiz, Ana Lúcia Tasca Gois, Silva, Luiz F, Silva, Siguara Bastos Lemos, Torre, Adriana Della   +4 more
core   +3 more sources

Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. [PDF]

, 2016
Notch is a key player in various developmental processes during the embryonic stage as well as in regulating tissue homeostasis, cell differentiation, and stem cell maintenance in adult life.
Dela Golshayan, Lucienne Juillerat-Jeanneret, Massard C., Müllberg J., Okada H., Rajesh Kumar, Shawber C.   +6 more
core   +1 more source

Synthesis of 3-aryl-3-benzazepines via aryne [1,2] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines

, 2018
An efficient method for the synthesis of 3-aryl-3-benzazepines via aryne induced [1,2] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines is described.
Xuan Pan, Zhanzhu Liu
semanticscholar   +1 more source

Designing organometallic compounds for catalysis and therapy [PDF]

, 2012
Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation.
Abraha Habtemariam, Aird, Alama, Alama, Alberto, Allardyce, Allen, Allen, Ana M. Pizarro, Anand, Ang, Ang, Anna Louisa Noffke, Arancibia, Barragan, Barry, Barry, Barry, Barry, Bergamo, Bergamo, Betanzos-Lara, Betanzos-Lara, Betanzos-Lara, Brewster, Bugarcic, Bugarcic, Canivet, Carrión, Caruso, Casini, Casini, Casini, Chaplin, Chen, Chen, del Pozo, Desmard, Dorcier, Dorcier, Dougan, Dougan, Dyson, Erxleben, Feng, Fernandez, Filak, Fu, Fu, Fujii, Giannini, Gormen, Gossens, Grau, Grguric-Sipka, Grubbs, Gröger, Guichard, Guo, Guo, Habtemariam, Hambley, Hamels, Hanif, Hanif, Harris, Hartinger, Hashiguchi, Hayes, Hayward, Herman, Hindi, Hogan, Hollmann, Hu, Hull, Ito, Jafarpour, Jennerwein, Jira, Jungwirth, Kandioller, Kisova, Kljun, Kopf, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kröger, Kuninobu, Lee, Leiva, Li, Liu, Liu, Liu, Liu, Liu, Lo, Lo, Lummen, Lutz, Maenaka, Meggers, Meggers, Meggers, Melchart, Melchart, Melchart, Melendez, Mendes, Motterlini, Mross, Novakova, Novakova, Novakova, Noyori, Noyori, Oehninger, Ogo, Ogo, Olliaro, Page, Patiño, Peacock, Peacock, Peacock, Peacock, Pelletier, Peter J. Sadler, Petzold, Petzold, Pitto-Barry, Pitto-Barry, Pizarro, Plazuk, Rocamora-Reverte, Ruiz, Ruppert, Sandoval, Sanford, Sarsam, Schatzschneider, Schmid, Schäfer, Scolaro, Selander, Skinner, Sriskandakumar, Steckhan, Strohfeldt, Suss-Fink, Sweeney, Takebayashi, Tan, Therrien, Therrien, Toney, Top, Top, Top, Trnka, Turel, van der Donk, van Rijt, van Rijt, van Rijt, Vessières, Vougioukalakis, Vougioukalakis, Wang, Wang, Wang, Ward, Williams, Williams, Wong, Wu, Wu, Yabluchanskiy, Yamakawa, Yan, Yano, Yuasa, Zava, Zekri, Zhao, Zoeller   +188 more
core   +1 more source

Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory. [PDF]

, 2016
RATIONALE: Antenatal exposure to the glucocorticoid dexamethasone dramatically increases the number of mesencephalic dopaminergic neurons in rat offspring.
Dalley, J.W., Dalley, J.W., Gillies, G.E., Gillies, G.E., Hensman, D., Hensman, D., Jupp, B., Jupp, B., Kentrop, J., Kentrop, J., McArthur, S., McArthur, S., Robbins, T.W., Robbins, T.W., Venus, B., Venus, B., Virdee, K., Virdee, K., Wilkinson, J., Wilkinson, J.   +19 more
core   +3 more sources

Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides [PDF]

, 2008
A number of new analogs of 3,3-dimethyl-4,5-dihydro-3H-2-benzazepine 2-oxide, structurally related to the nitrone spin trap α-phenyl-N-tert-butylnitrone (PBN), were synthesized and evaluated for their activity in vitro as protectants against oxidative ...
Altomare, Cosimo, de Candia, Modesto, Méndez-Álvarez, Estefanía, Soto-Otero, Ramón, Sánchez Iglesias, Sofía, Varlamov, Alexey V., Voskressensky, Leonid G., Zubkov, Fedor I.   +7 more
core   +1 more source

Azabicyclo chemistry II. Synthesis of 1,5‐methano‐2,3,4,5‐tetrahydro‐1H‐2‐benzazepines. B‐norbenzomorphans [PDF]

, 1970
Michael Mokotoff, Arthur E. Jacobson
openalex   +1 more source

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase [PDF]

, 2015
Objectives (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H37Rv. A biomimetic approach for the chemical synthesis of a wide array of 1-
Angell, R, Barrera, DA, Bhakta, S, Cuca, LE, Davies, HM, Evangelopoulos, D, Gershater, MC, Guzman, JD, Hailes, HC, Lamming, ED, Maitra, A, McMahon, E, Mortazavi, PN, Munshi, T, Needham, D, Pesnot, T, Redmond, JM, Ward, JM   +17 more
core   +1 more source

A primordial dopamine D1‐like adenylyl cyclase‐linked receptor from Drosophila melanogaster displaying poor affinity for benzazepines [PDF]

, 1995
Kim S. Sugamori, Lidia Demchyshyn, Fortunata McConkey, Michael Forte, Hyman B. Niznik   +4 more
openalex   +1 more source