Optimized psilocybin production in tryptophan catabolism‐repressed fungi
Microbial Biotechnology, Volume 17, Issue 11, November 2024.Here, we developed an in vivo psilocybin production chassis, based on repression of l‐tryptophan catabolism. By genome mining, we identified two aminotransferase ARO8/9 orthologs in Aspergillus nidulans involved in l‐tryptophan catabolism. Double deletion of the aminotransferase genes aroH1 and aroH2 resulted in a 10‐fold increased psilocybin ...
Slavica Janevska +12 more
wiley +1 more source
D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia [PDF]
, 2009 YesPhencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The aim was to investigate the efficacy of the D1-like receptor agonist, SKF-38393, to improve PCPinduced deficits in the novel object recognition (NOR ...
Abdul-Monim +84 more
core +1 more source
Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review
ChemMedChem, Volume 19, Issue 9, May 2, 2024.Searching for a cure for neuroblastoma: This review highlights the urgent need to find a cure for high‐risk neuroblastoma. It provides an overview of the current treatment available and the drug discovery approach of seven drugs that reached clinical trial.
A. Gerges, U. Canning
wiley +1 more source
Novas metodologias sintéticas utilizando reator de micro-ondas fundamentadas nos princípios da química verde (azidas alílicas e reações de cicloadição) [PDF]
, 2010 TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.Este trabalho objetiva a preparação de compostos nitrogenados multifuncionais e de sistemas alílicos contendo o grupo azido, os quais são
Monteiro, Gustavo Claro
core
Ready access to 7,8-dihydroindolo[2,3-d][1]benzazepine-6(5H)-one scaffold and analogues via early-stage Fischer ring-closure reaction [PDF]
, 2022 Irina Kuznetcova +4 more
openalex +1 more source
New Catalytic Routes to Benzofused Seven-Membered Azaheterocycles [PDF]
, 2021 Benzazepines, benzodiazepines and benzoxazepines compose a privileged family of natural products and pharmaceuticals. Their remarkable biological activity made them useful drugs to treat a large variety of issues.
Velasco Rubio, Álvaro
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ChemBioChem, Volume 25, Issue 2, January 15, 2024.We herein report the identification of UR‐NR435 (25), a SCH‐23390‐based fluorescent ligand bearing a 5‐TAMRA dye, as suitable for fluorescence microscopy at the D1R. Single‐digit nanomolar binding affinity could be determined in radioligand competition binding and molecular brightness studies at D1‐like receptors.
Niklas Rosier +11 more
wiley +1 more source
Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles [PDF]
, 2013 RNA editing at the Q/R site near the apex of the pore loop of AMPA and kainate receptors controls a diverse array of channel properties, including ion selectivity and unitary conductance and susceptibility to inhibition by polyamines and cis-unsaturated ...
Boland +67 more
core +2 more sources
A suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst [PDF]
, 2010 The preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines, N-sulfonyl-2,3,4,5-tetrahydro-1H-2-benzazepines and N-sulfonyl-1,2,3,4,5,6-hexahydrobenzazocine was catalyzed by a Preyssler heteropolyacid, H₁₄[NaP₅W₃₀O₁₁₀], (PA), supported on silica ...
Autino, Juan Carlos +3 more
core +1 more source
One-Pot Phosphate-Mediated Synthesis of Novel 1,3,5-Trisubstituted Pyridinium Salts: A New Family of S. aureus Inhibitors [PDF]
, 2017 Polysubstituted pyridinium salts are valuable pharmacophores found in many biologically active molecules. Their synthesis typically involves the use of multistep procedures or harsh reaction conditions.
Edwards, M +4 more
core +1 more source