Results 61 to 70 of about 6,469 (247)

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase [PDF]

, 2015
Objectives (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H37Rv. A biomimetic approach for the chemical synthesis of a wide array of 1-
Angell, R, Barrera, DA, Bhakta, S, Cuca, LE, Davies, HM, Evangelopoulos, D, Gershater, MC, Guzman, JD, Hailes, HC, Lamming, ED, Maitra, A, McMahon, E, Mortazavi, PN, Munshi, T, Needham, D, Pesnot, T, Redmond, JM, Ward, JM   +17 more
core   +1 more source

A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization. [PDF]

, 2010
BACKGROUND: G protein-coupled receptors (GPCRs) represent a family of well-characterized drug targets with significant therapeutic value. Phylogenetic classifications may help to understand the characteristics of individual GPCRs and their subtypes ...
Bender, Andreas, Beukers, Margot W, Emmerich, Michael TM, Ijzerman, Adriaan P, Lane, Jonathan R, Okuno, Yasushi, Peironcely, Julio E, van der Horst, Eelke, van Vlijmen, Herman WT   +8 more
core   +4 more sources

Shedding Light on the D1‐Like Receptors: A Fluorescence‐Based Toolbox for Visualization of the D1 and D5 Receptors**

ChemBioChem, Volume 25, Issue 2, January 15, 2024.
We herein report the identification of UR‐NR435 (25), a SCH‐23390‐based fluorescent ligand bearing a 5‐TAMRA dye, as suitable for fluorescence microscopy at the D1R. Single‐digit nanomolar binding affinity could be determined in radioligand competition binding and molecular brightness studies at D1‐like receptors.
Niklas Rosier, Denise Mönnich, Martin Nagl, Hannes Schihada, Alexei Sirbu, Nergis Konar, Irene Reyes‐Resina, Gemma Navarro, Rafael Franco, Peter Kolb, Paolo Annibale, Steffen Pockes   +11 more
wiley   +1 more source

D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia [PDF]

, 2009
YesPhencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The aim was to investigate the efficacy of the D1-like receptor agonist, SKF-38393, to improve PCPinduced deficits in the novel object recognition (NOR ...
Abdul-Monim, Abdul-Monim, Abdul-Monim, Amico, Apud, Arnsten, Benes, Benes, Briggs, Brown, Buchanan, Cahill, Castner, Ciliax, Creese, Davis, Dawson, Finger, Fletcher, Fletcher, George, Goldman-Rakic, Goldman-Rakic, Grace, Granon, Gray, Grayson, Grayson, Green, Guillin, Hagan, Hagger, Harvey, Haut, Hersi, Hirvonen, Ichikawa, Idris, Javitt, Jentsch, Jentsch, Jentsch, Joanna C. Neill, Kashima, Kebabian, Keefe, Kolb, Lahti, Lawler, Levey, Lidow, Lieberman, Marder, Marie L. Woolley, McAlonan, McLean, McLean, Meador-Woodruff, Meltzer, Meunier, Mu, Murray, Nagi F. Idris, Neill, Neill, Neumeyer, Okubo, Pantelis, Qandil, Rossi, Samantha L. McLean, Sawaguchi, Seeman, Siuciak, Snigdha, Snigdha, Snigdha, Snigdha, Spano, Steele, Sutcliffe, Sutcliffe, Tait, Tunbridge, Vincent   +84 more
core   +1 more source

Rh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted 1,4‐ Dihydroquinazolin‐2‐amines [PDF]

, 2015
NOTICE: This is the peer reviewed version of the following article: Cajaraville, A., Suárez, J., López, S., Varela. J. A., Saá, C. (2015). Rh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted ...
Cajaraville Leiro, Ana, López Estévez, Susana, Saá Rodríguez, Carlos, Suárez Rivero, Jaime, Varela Carrete, Jesús Ángel   +4 more
core   +1 more source

Novas metodologias sintéticas utilizando reator de micro-ondas fundamentadas nos princípios da química verde (azidas alílicas e reações de cicloadição) [PDF]

, 2010
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.Este trabalho objetiva a preparação de compostos nitrogenados multifuncionais e de sistemas alílicos contendo o grupo azido, os quais são
Monteiro, Gustavo Claro
core  

A novel, tandem construction of C-N and C-C bonds: facile and one-pot transformation of the Baylis-Hillman adducts into 2-benzazepines [PDF]

, 2004
A novel reaction involving tandem construction of C-N and C- C bonds via the simultaneous Ritter and Houben-Hoesch reactions on Baylis-Hillman adducts leading to a convenient, one-pot synthesis of 2-benzazepine derivatives is described.
Basavaiah, Deevi, Satyanarayana, Tummanapalli   +1 more
core   +1 more source

Conjugation of Organoruthenium(II) 3-(1H-Benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and Indolo[3,2-d]benzazepines to Recombinant Human Serum Albumin: a Strategy To Enhance Cytotoxicity in Cancer Cells [PDF]

, 2011
Five organoruthenium complexes [RuCl(η6-arene)(L)]Cl with a modified arene ligand, namely, 4-formylphenoxyacetyl-η6-benzylamide, and L = 3-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines or indolo[3,2-d]benzazepines were synthesized and conjugated to ...
Ang W. H., Ang W. H., Ang W. H., Angela Casini, Bergamo A., Bernhard K. Keppler, Brewer E., Bruijnincx P. C. A., Chatterjee S., Cho K., Chuang V. T. G., Dobrov A., Dosio F., Dyson P. J., Fabio Edafe, Filak L. K., Garmann D., Ginzinger W., Haag R., Haley B., Hartinger C. G., Hawkins M. J., Iryna N. Stepanenko, Kratz F., Kratz F., Kratz F., Kratz F., Maria S. Novak, Michael A. Jakupec, Modi S., Paul J. Dyson, Peacock A. F. A., Primik M. F., Rapoport N., Sanchez-Cano C., Schmid W. F., Schmid W. F., Schmid W. F., Scolaro C., Sheldrick G. M., Stepanenko I. N., Vladimir B. Arion, Warnecke A., Yokoyama M.   +43 more
core   +2 more sources

Seven-membered Rings Through Metal-free Rearrangement Mediated By Hypervalent Iodine. [PDF]

, 2015
A versatile and metal-free approach for the synthesis of carbocycles and of heterocycles bearing seven- and eight-membered rings is described. The strategy is based on ring expansion of 1-vinylcycloalkanols (or the corresponding silyl or methyl ether ...
de Carvalho, João Ernesto, Ruiz, Ana Lúcia Tasca Gois, Silva, Luiz F, Silva, Siguara Bastos Lemos, Torre, Adriana Della   +4 more
core   +3 more sources

Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles [PDF]

, 2013
RNA editing at the Q/R site near the apex of the pore loop of AMPA and kainate receptors controls a diverse array of channel properties, including ion selectivity and unitary conductance and susceptibility to inhibition by polyamines and cis-unsaturated ...
Boland, Bolivar, Bowie, Bowie, Brohawn, Bruno, Burnashev, Burnashev, Bähring, Carter, Chatelain, Decher, Dingledine, Doyle, Eswar, Flynn, Gonzalez, Greger, Heler, Hidalgo, Hille, Howe, Huettner, James E. Huettner, Kamboj, Kato, Koh, Kollewe, Körber, Lingle, Ma-Högemeier, Mayer, Melany N. Lopez, Miller, Miller, Panchenko, Panchenko, Patel, Payandeh, Payandeh, Perozo, Ranganathan, Roche, Rosenhouse-Dantsker, Rosenhouse-Dantsker, Rosenthal, Rozov, Salussolia, Schorge, Schreiber, Shen, Siegler Retchless, Sigworth, Smithers, Sobolevsky, Sobolevsky, Sommer, Swanson, Swartz, Terhag, Timothy J. Wilding, Traynelis, Valiyaveetil, Wilding, Wilding, Wilding, Wilding, Wilding   +67 more
core   +2 more sources