Results 11 to 20 of about 8,103 (214)

Benzenesulfonamide Analogs: Synthesis, Anti-GBM Activity and Pharmacoprofiling

International Journal of Molecular Sciences, 2023
The tropomyosin receptor kinase A (TrkA) family of receptor tyrosine kinases (RTKs) emerge as a potential target for glioblastoma (GBM) treatment. Benzenesulfonamide analogs were identified as kinase inhibitors possessing promising anticancer properties.
Konda Mani Saravanan, Thiyagarajan Ramesh, Suresh Palanivel   +2 more
exaly   +6 more sources

The crystal structures and Hirshfeld surface analysis of the 2-iodophenyl- and 4,5-difluoro-2-iodophenyl derivatives of benzenesulfonamide [PDF]

Acta Crystallographica Section E: Crystallographic Communications
Two new benzenesulfonyl derivatives, N-(2-iodophenyl)benzenesulfonamide, C12H10INO2, (I), and N-(4,5-difluoro-2-iodophenyl)benzenesulfonamide, C12H8F2INO2S, (II) were synthesized and structurally characterized.
Sundarasamy Madhan, MohamedHanifa NizamMohideen, Vinayagam Pavunkumar, Arasambattu K. MohanaKrishnan   +3 more
doaj   +3 more sources

Synthesis and Structure of N-(1-(Bromomethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl)benzenesulfonamide

Molbank, 2023
A new bicyclic sulfonamide derivative, N-(1-(bromomethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl)benzenesulfonamide, was synthesized in the reaction of benzenesulfonamide and camphene in the presence of N-bromosuccinimide in acetonitrile.
Ivan A. Garagan, Mikhail Yu. Moskalik, Irina V. Sterkhova, Anton S. Ganin   +3 more
doaj   +2 more sources

Discovery of Pyrazoline Benzenesulfonamide Derivatives as Anticancer Agents: A Review. [PDF]

Drug Des Devel Ther
Pyrazoline benzenesulfonamide derivatives represent a distinctive class of heterocyclic compounds that synergistically combine the pharmacological versatility of the pyrazoline scaffold with the enzyme-inhibitory prowess of benzenesulfonamide moieties. These hybrids have emerged as promising candidates in anticancer drug discovery.
Hasyim DM, Musfiroh I, Hendra R, Kamarulzaman EE, Ritmaleni R, Muchtaridi M.   +5 more
europepmc   +4 more sources

N-(4-Methoxyphenyl)benzenesulfonamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
في مركب العنوان، C(13)H(13)NO(3)S، تكون حلقة البنزين لشطر البنزين- سلفوناميد مضطربة بنسبة إشغال 0.56 (3):0.44 (3)، ويتم لف مكونات الاضطراب بزاوية 21 (1) درجة مع بعضها البعض. مجموعة الميثوكسي بنزين مستوية تقريبًا (انحراف الجذر التربيعي = 0.0144 Å) ويتم إزاحة ذرة أميد N من هذا المستوى بمقدار 0.090 (6) Å.
Slamet Ibrahim, Muhammad Nawaz Tahir, Naveed Iqbal, Durre Shahwar, Muhammad Asam Raza   +4 more
openaire   +3 more sources

Synthesis and Monoamine Oxidase Inhibition Properties of 4-(2-Methyloxazol-4-yl)benzenesulfonamide

Molbank
4-(2-Methyloxazol-4-yl)benzenesulfonamide was synthesized by the reaction of 4-(2-bromoacetyl)benzenesulfonamide with an excess of acetamide. The compound was evaluated as a potential inhibitor of human monoamine oxidase (MAO) A and B and was found to ...
Anton A. Shetnev, Julia A. Efimova, Mikhail K. Korsakov, Anél Petzer, Jacobus P. Petzer   +4 more
doaj   +2 more sources

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
We report the synthesis and characterisation of a novel series of triazole benzenesulfonamide derivatives, which incorporate the general pharmacophore associated with carbonic anhydrase (CA, EC 4.2.1.1) inhibitors.
Marwa G El-Gazzar, Alessio Nocentini, Mostafa M Ghorab   +2 more
exaly   +2 more sources

Synthesis of Novel Benzenesulfonamide-Bearing Functionalized Imidazole Derivatives as Novel Candidates Targeting Multidrug-Resistant Mycobacterium abscessus Complex

Microorganisms, 2023
Infections caused by drug-resistant (DR) Mycobacterium abscessus (M. abscessus) complex (MAC) are an important public health concern, particularly when affecting individuals with various immunodeficiencies or chronic pulmonary diseases.
Benas Balandis, Povilas Kavaliauskas, Birutė Grybaitė, Vidmantas Petraitis, Rūta Petraitienė, Ethan Naing, Andrew Garcia, Ramunė Grigalevičiūtė, Vytautas Mickevičius   +8 more
doaj   +2 more sources

Small-molecule screen in C. elegans identifies benzenesulfonamides as inhibitors of microsporidia spores [PDF]

npj Antimicrobials and Resistance
Microsporidia, a large group of fungal-related intracellular parasites, infect several economically significant animals, leading to substantial economic losses.
Qingyuan Huang, Haiyi Jiang, Junhong Wei, Yabin Dou, Guoqing Pan, Jie Chen, Aaron W. Reinke   +6 more
doaj   +2 more sources

The Identification and synthesis of metabolites of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide

Research Results in Pharmacology
Introduction: 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide is a new selective type II carbonic anhydrase inhibitor with local action through instillation into the eyes. For a complete pharmacokinetic study of this drug, it is necessary to detect
Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Valeria A. Panova, Julia A. Efimova, Sergey A. Ivanovskiy, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov   +8 more
doaj   +2 more sources