Results 21 to 30 of about 8,103 (214)

Benzenesulfonamide compounds for somatic embryogenesis in plants

, 2014
Benzenesulfonamide compounds potentiate 2,4-D induced embryogenesis in plants. In particular, 4-chloro-N-methyl-N-(2-methylphenyl) benzenesulfonamide and analogs induce somatic embryogenesis in plants. Methods of inducing somatic embryogenesis comprise exposing selected plant tissues, e.g. seed embryos, to auxins, e.g.
Fiers, M.A., Boutilier, K.A.
openaire   +2 more sources

99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting [PDF]

Scientific Reports
Sulfonamide derivatives are a significant class of medicinal compounds. Gold nanoparticles (AuNPs) offer precise cancer treatment through targeted delivery, boasting high drug-loading capacity and low toxicity.
Adli A. Selim, Tamer M. Sakr, Basma M. Essa, Galal H. Sayed, Kurls E. Anwer   +4 more
doaj   +2 more sources

4-(5-Chloro-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β-Catenin Signaling Pathway, and P-Glycoprotein. [PDF]

ChemMedChem
Polypharmacology is expected to produce higher therapeutic efficacy and lower cytotoxic and side effects. Compound 15 exhibited strong inhibition of the human carbonic anhydrase isoforms IX and XII and selectivity toward the adverse isoforms I and II.
Puxeddu M, Bordone R, Colla C, Rotili G, Coluccia A, Sciò P, Cuřínová P, Nocentini A, Supuran CT, Filiberti S, Turati M, Ronca R, Kopecka J, Riganti C, Jimenez L, Link W, Bigogno C, Dondio G, Barba M, Canettieri G, Silvestri R, La Regina G.   +21 more
europepmc   +2 more sources

Quantitative Competition Binding of Fluorinated Ligands by Real-Time ¹⁹F In-Cell NMR to Assess Isoform Selectivity in Human Cells. [PDF]

Magn Reson Chem
Real‐time in‐cell 19F NMR spectroscopy in a flow NMR bioreactor was used to monitor the binding of fluorinated compounds to three cytosolic carbonic anhydrase isoforms in living human cells. The simultaneous observation of the two ligands allowed for the quantitative ranking of their intracellular affinities by competition binding. This approach allows
Costantino A, Barbieri L, Giovannuzzi S, Nocentini A, Supuran CT, Luchinat E.   +5 more
europepmc   +2 more sources

Crystal structures of three N-acylhydrazone isomers

Acta Crystallographica Section E: Crystallographic Communications, 2021
The crystal structures of three isomers of (E)-4-chloro-N-{2-[2-(chlorobenzylidene)hydrazinyl]-2-oxoethyl}benzenesulfonamide, namely, (E)-4-chloro-N-{2-[2-(2-chlorobenzylidene)hydrazinyl]-2-oxoethyl}benzenesulfonamide (I), (E)-4-chloro-N-{2-[2-(3 ...
H. Purandara, Sabine Foro, B. Thimme Gowda   +2 more
doaj   +1 more source

SYNTHESIS OF SOME NEW DERIVATIVES OF ISOINDOLINE-1,3-DIONE NUCLEUS FOR ANTIHYPERGLYCEMIC EVALUATION [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2013
In order to produce potent new leads for antidiabetic drugs, a new series of isoindoline-1,3-dione analogues bearing aryl sulfonylurea moieties were synthesized and screened for their antihyperglycemic activity.
Ibrahim Eissa
doaj   +1 more source

Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases

Pharmaceuticals, 2022
A series of novel benzenesulfonamide derivatives were synthesized bearing para-N β,γ-amino acid or para-N β-amino acid and thiazole moieties and their binding to the human carbonic anhydrase (CA) isozymes determined. These enzymes are involved in various
Benas Balandis, Tomas Šimkūnas, Vaida Paketurytė-Latvė, Vilma Michailovienė, Aurelija Mickevičiūtė, Elena Manakova, Saulius Gražulis, Sergey Belyakov, Visvaldas Kairys, Vytautas Mickevičius, Asta Zubrienė, Daumantas Matulis   +11 more
doaj   +1 more source

A benzenesulfonamide derivative as a novel PET radioligand for CXCR4 [PDF]

Bioorganic & Medicinal Chemistry, 2020
CXCR4 is involved in various diseases such as inflammation, tumor growth, and cancer metastasis through the interaction with its natural endogenous ligand, chemokine CXCL12. In an effort to develop imaging probes for CXCR4, we developed a novel small molecule CXCR4-targeted PET agent (compound 5) by combining our established benzenesulfonamide scaffold
Yoon Hyeun, Oum, Dinesh, Shetty, Younghyoun, Yoon, Zhongxing, Liang, Ronald J, Voll, Mark M, Goodman, Hyunsuk, Shim   +6 more
openaire   +2 more sources

Evaluation of the Antimicrobial Activity of N-Acylated 4-Chloro-2-mercaptobenzenesulfonamide Derivatives

Medical Sciences Forum, 2022
Aryl/heteroarylsulfonamides are an important group of compounds with different directions of biological activity. The number of literature reports on the antibacterial activity of sulfonamides is steadily increasing, bringing a lot of interesting data on
Anita Bułakowska, Jarosław Sławiński, Rafał Hałasa   +2 more
doaj   +1 more source

Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation

International Journal of Biological Macromolecules, 2023
Amyloid fibrils are protein aggregates formed by protein assembly through cross β structures. Inhibition of amyloid fibril formation may contribute to therapy against amyloid-related disorders like Parkinson's, Alzheimer's, and type 2 diabetes. Here we report that several fluorinated sulfonamide compounds, previously shown to inhibit human carbonic ...
Hadi Ali Janvand, Saeid, Ladefoged, Lucy Kate, Zubrienė, Asta, Sakalauskas, Andrius, Christiansen, Gunna, Dudutienė, Virginija, Schiøtt, Birgit, Matulis, Daumantas, Smirnovas, Vytautas, Otzen, Daniel E.   +9 more
openaire   +2 more sources