Results 1 to 10 of about 4,762 (102)

N‐benzhydryl quinuclidine compounds are a potent and Src kinase‐independent inhibitor of NALCN channels [PDF]

British Journal of Pharmacology, 2020
Background and PurposeNALCN is a Na+ leak, GPCR‐activated channel that regulates the resting membrane potential and neuronal excitability. Despite numerous possible roles for NALCN in both normal physiology and disease processes, lack of specific blockers hampers further investigation.Experimental ApproachThe effect of N‐benzhydryl quinuclidine ...
Suyun Hahn, So Woon Kim, Ki Bum Um, Hyun Jin Kim, Myoung Kyu Park   +4 more
openaire   +2 more sources

Enzymatic synthesis of novel pyrrole esters and their thermal stability

BMC Chemistry, 2023
In the present work a simple enzymatic approach (Novozym 435) for transesterification to synthesize pyrrole esters was reported. To generate the best reaction conditions, which resulted in the optimum yield of 92%, the effects of lipase type, solvent ...
Jingyi Hu, Meng Zhou, Yujie Zhang, Xi Zhang, Xiaoming Ji, Mingqin Zhao, Miao Lai   +6 more
doaj   +1 more source

Hydantoin Derivatives of L- and D-amino acids: Synthesis and Evaluation of Their Antiviral and Antitumoral Activity

Molecules, 2006
3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h wereprepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L-and D-amino acid amides 4a-h.
Mladen Mintas, Erik De Clercq, Jan Balzarini, KreÅ¡imir Pavelic, Marijeta Kralj, Katja Ester, Silvana Raic-Malic, Branka Zorc, Zrinka Rajic   +8 more
doaj   +1 more source

Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity

E-Journal of Chemistry, 2004
Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassium α,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4 ...
S. R. Dhol, P. M. Gami, R. C. Khunt, A. R. Parikh   +3 more
doaj   +1 more source

Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The synthesis of a new series of sulfamides incorporating ortho-, meta, and para-benzenesulfamide moieties is reported, which were investigated for the inhibition of two human (h) isoforms of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I and
Silvia Bua, Emanuela Berrino, Sonia Del Prete, Vallabhaneni S. Murthy, Vijayaparthasarathi Vijayakumar, Yasinalli Tamboli, Clemente Capasso, Elisabetta Cerbai, Alessandro Mugelli, Fabrizio Carta, Claudiu T. Supuran   +10 more
doaj   +1 more source

Proton Chemical Shifts in Some Benzhydryl Compounds. [PDF]

Acta Chemica Scandinavica, 1970
Leiv J. Stangeland, Jon Songstad, Torsten Nilsson, Kurt Torssell, S. E. Rasmussen, Erling Sunde, Nils Andreas Sørensen   +6 more
openaire   +1 more source

Syntheses of Organic Fluorine Compounds. IV. : Syntheses and Pharmacological Study of Fluorine-substituted Benzhydryl Aminopropyl Ethers

YAKUGAKU ZASSHI, 1967
K, Takatori, S, Hisada, S, Asano, T, Nakashima, H, Okumura   +4 more
openaire   +3 more sources

Studies on the Addition Compounds between β-Dimethylaminoethyl Benzhydryl Ether and Chlorophenol Derivatives

YAKUGAKU ZASSHI, 1954
Norio Sugimoto, Masao Tsuruoka, Motonosuke Kakuma   +2 more
openaire   +2 more sources

Syntheses of Organic Fluorine Compounds. V. : Syntheses and Pharmacological Study of Quaternary Ammonium Salts of Fluorine-substituted Benzhydryl Aminoethyl Ethers

YAKUGAKU ZASSHI, 1969
HIDEOMI FUKUDA, KAZUO WATANABE, NOBUKO NAKAMURA, CHIZUKO HOSHINO, KOJI MIZUKAMI, KICHITARO TAKATORI   +5 more
openaire   +3 more sources

Structural Exploitation of Cinnarizine Identified Novel Drug-Like Anthelmintic Agents Against <i>Angiostrongylus cantonensis</i>. [PDF]

ACS Infect Dis
Lemes BL, Siegl-Breno MA, Silva-Nunes MK, Lopes FB, Silva AS, Motta NEP, de Moraes J, Fernandes JPS.   +7 more
europepmc   +1 more source