Results 11 to 20 of about 6,338 (167)

N‐benzhydryl quinuclidine compounds are a potent and Src kinase‐independent inhibitor of NALCN channels [PDF]

British Journal of Pharmacology, 2020
Background and PurposeNALCN is a Na+ leak, GPCR‐activated channel that regulates the resting membrane potential and neuronal excitability. Despite numerous possible roles for NALCN in both normal physiology and disease processes, lack of specific blockers hampers further investigation.Experimental ApproachThe effect of N‐benzhydryl quinuclidine ...
Suyun Hahn, So Woon Kim, Ki Bum Um, Hyun Jin Kim, Myoung Kyu Park   +4 more
openaire   +3 more sources

Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity [PDF]

European journal of medicinal chemistry, 2021
Due to the surge in resistance to common therapies, malaria remains a significant concern to human health worldwide. In chloroquine (CQ)-resistant (CQ-R) strains of Plasmodium falciparum, CQ and related drugs are effluxed from the parasite's digestive ...
Taramelli D., D'Alessandro S., Martin R. E., Babij S. K., Tapanelli S., Pozzetti L., Gemma S., Caldelari R., Butini S., Lamponi S., Federico S., Shafik S. H., Campiani G., Summers R. L., Relitti N., Habluetzel A.   +15 more
core   +2 more sources

C5-alkyl and C5-aryl Substituted 5-Deazaflavin as Sensitizers for Photodehalogenation of Aryl Halides [PDF]

Molecules
Aryl halides are important intermediates for chemical synthesis. However, the negative reduction potential up to −2.7 V (vs. SCE) makes photoredox conversion of aryl halides by reductive dehalogenation to aryl radicals for chemical transformations ...
Huimin Guo, Xing Guan, Heping Li, Weihua Guo   +3 more
doaj   +2 more sources

Hydantoin Derivatives of L- and D-amino acids: Synthesis and Evaluation of Their Antiviral and Antitumoral Activity

Molecules, 2006
3,5-Disubstituted hydantoin (1,3-imidazolidinedione) derivatives 5a-h wereprepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L-and D-amino acid amides 4a-h.
Mladen Mintas, Erik De Clercq, Jan Balzarini, KreÅ¡imir Pavelic, Marijeta Kralj, Katja Ester, Silvana Raic-Malic, Branka Zorc, Zrinka Rajic   +8 more
doaj   +2 more sources

Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity

E-Journal of Chemistry, 2004
Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassium α,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4 ...
S. R. Dhol, P. M. Gami, R. C. Khunt, A. R. Parikh   +3 more
doaj   +2 more sources

Proton Chemical Shifts in Some Benzhydryl Compounds. [PDF]

Acta Chemica Scandinavica, 1970
Leiv J. Stangeland, Jon Songstad, Torsten Nilsson, Kurt Torssell, S. E. Rasmussen, Erling Sunde, Nils Andreas Sørensen   +6 more
openaire   +2 more sources

Studies on the Addition Compounds between β-Dimethylaminoethyl Benzhydryl Ether and Chlorophenol Derivatives

YAKUGAKU ZASSHI, 1954
Norio Sugimoto, Masao Tsuruoka, Motonosuke Kakuma   +2 more
openaire   +3 more sources

Enzymatic synthesis of novel pyrrole esters and their thermal stability

BMC Chemistry, 2023
In the present work a simple enzymatic approach (Novozym 435) for transesterification to synthesize pyrrole esters was reported. To generate the best reaction conditions, which resulted in the optimum yield of 92%, the effects of lipase type, solvent ...
Jingyi Hu, Meng Zhou, Yujie Zhang, Xi Zhang, Xiaoming Ji, Mingqin Zhao, Miao Lai   +6 more
doaj   +1 more source

Why Can Cationic Halogen Bond Donors Activate the Ritter-Type Solvolysis of Benzhydryl Bromide but Cationic Hydrogen Bond Donors Can Not?

ACS Omega, 2020
It is found by experiment that the cationic halogen bond donors (cationic iodoimidazolium compounds) can activate the Ritter-type solvolysis of benzhydryl bromide, while the cationic hydrogen bond donors (cationic imidazolium compounds) could not.
Yueyan Wang, Peifeng Su
semanticscholar   +1 more source

<i>ortho/para</i>-Chlorinated α‑Diimine Nickel Precatalysts Resulting Polyethylenes with Improved Mechanical Properties and Controlled Crystallinity. [PDF]

ACS Omega
A series of ortho/para-chlorinated N-(6-benzhydryl-2,4-dichlorophenylimino)-N’-aryliminoacenaphthylene derivatives as ligands (L1-L6, aryl = 2,6-dimethylphenyl (L1), 2,6-diethylphenyl (L2), 2,6-diisopropylphenyl (L3), 2,4,6-trimethylphenyl (L4), 2,6 ...
Xi A, Zhang Q, Zeng Y, Wang Y, Wang Q, Ma Y, Hao X, Sun WH.   +7 more
europepmc   +2 more sources