Results 11 to 20 of about 5,281 (113)

Zwitterionic Penicillin-Derived Sulfone Inhibitor for Combating β-Lactamase-Mediated Antibiotic Resistance. [PDF]

ChemMedChem
Combining enhanced permeability strategies with (2‐pyridyl)methylene substitution in the sulbactam scaffold led to a novel β‐lactamase inhibitor to combat β‐lactamase‐mediated resistance to β‐lactam antibiotics. The studies presented highlight the potential of compound 3 as a next‐generation β‐lactamase inhibitor for combating infections caused by ...
Rodríguez D, Lence E, Vázquez-Ucha JC, Beceiro A, González-Bello C.   +4 more
europepmc   +2 more sources

Enantioselective Synthesis of a New Class of Stable and Functionalized Cyclopentadienes via CuH‐Catalysis

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
Cyclopentadienes (CpHs) are fundamental building blocks with widespread applications in chemistry. However, their inherent acidity and isomeric instability have long limited access to chiral variants in an asymmetric fashion. Here, we introduce a CuH‐catalyzed asymmetric transformation that provides an unprecedented entry into a new class of ...
Piero Soppelsa, Riccardo Bellin, Besma Boulila, Francesco Vaghi, Manuel Orlandi   +4 more
wiley   +2 more sources

Rapid and Stereoselective Ring‐Opening Polymerization of rac‐Lactide Enabled by a Chiral Cyclopropenimine–Thiourea Catalyst

Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.
Chiral cyclopropenimine–thiourea organocatalysts enabled both high reactivity and precise stereocontrol in the ring‐opening polymerization of rac‐lactide. The bifunctional system exhibited a TOF up to 1,710 h−1 with Pm = 0.90 at 25°C, and achieved Pm = 0.99 at −78°C while maintaining a TOF of 16.3 h−1.
Sumin Lee, Hooseung Lee, Hyeongwoo Nam, Seungyun Jo, Minseong Kim, Dongwook Kim, Du Yeol Ryu, Sarah Yunmi Lee, Byeong‐Su Kim   +8 more
wiley   +2 more sources

Direct C─H Lactonization of Carboxylic Acids Enabled by LMCT Photoactivation

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
We report a photochemical method for oxidative γ‐C─H lactonization of simple carboxylic acid substrates upon LMCT photoactivation. Intriguingly, these conditions suppress the rapid decarboxylation characteristic of oxidized carboxylates, suggesting the intermediacy of metal‐stabilized acyloxy radical instead of the dissociative process typically ...
Kathryn M. Weber, Rodrigo Villanueva, Mihai V. Popescu, Grace A. Lutovsky, Samuel N. Gockel, Robert S. Paton, Tehshik P. Yoon   +6 more
wiley   +2 more sources

Targeting the Carotid Body Function With Big‐K+‐Channel Blocker ENA‐001 in Opioid‐Induced Respiratory Depression: A Scoping Review

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Opioids, most intravenous anesthetics and various illicit substances can cause fatal respiratory depression by depressing central respiratory networks. ENA‐001, a ventilatory modulator targeting the carotid bodies, has emerged as a potential countermeasure without impairing analgesia or hypnosis.
Jimmy J. Arevalo, Monique van Velzen, Simone C. Jansen, Maarten van Lemmen, Elise Sarton, Albert Dahan, Erik Olofsen, Joseph F. Cotten, Marieke Niesters, Rutger M. van der Schrier   +9 more
wiley   +1 more source

Gallium‐Catalyzed Tandem Carbonyl–Olefin Metathesis/Dehydrogenative Coupling Enables Rapid Access to Cyclopentenes

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
A cationic gallium(III) catalyst enables rapid construction of substituted cyclopentenes via tandem carbonyl‐ene metathesis/Friedel–Crafts coupling. Electronic tuning of alcohol electrophiles allows access to diverse, densely functionalized rings in a single operation.
Arnaud Espied, Djamila Azrou, Alexandre Djurovic, Régis Guillot, Aurélien Alix, Vincent Gandon, Christophe Bour   +6 more
wiley   +1 more source

Brønsted Acid‐Catalyzed Direct N‐Alkylation of Anilines With Alcohols

ChemistrySelect, Volume 11, Issue 22, 11 June 2026.
Brønsted acid‐catalyzed methodology for the alkylation of anilines with alcohols has been developed. The reaction occurs in short reaction time with excellent functional group tolerance. A broad range of aniline and alcohol derivatives generates the desired adducts in good to excellent yields.
Rony Gantous, Yuri Bolshan
wiley   +1 more source

A Gallium(I) β‐Amido‐Imino‐Phosphorane: A Five‐Membered N‐Heterocyclic Gallylene with Enhanced Nucleophilicity

ChemistryEurope, Volume 4, Issue 5, May 2026.
By introducing β‐amino‐imino‐phosphoranes (BAIPs) as a new class of strongly electron‐donating N,N’‐chelates, an N‐heterocyclic gallylene (NHGa) with enhanced nucleophilicity is obtained. The new NHGa is readily synthesized, and the ligand features potent 1H and 31P NMR probes for reaction control.
Aylin Nagel, Samuel R. Lawrence, Tobias Rüffer, Robert Kretschmer   +3 more
wiley   +1 more source

Development of a Novel Polyleucine‐Based Immunopotentiator for Subunit Vaccines Against Group A Streptococcus

Small, Volume 22, Issue 22, 17 April 2026.
Self‐assembling amphiphilic peptide L15K6 is used as a novel immunoadjuvant for the development of a Group A Streptococcus vaccine. Robust antigen‐specific IgG responses are generated and manage to kill isolated strains of Group A Streptococcus. Cellular and bulk RNA sequencing data reveals that L15K6 regulates immune responses potentially through TLR ...
Lantian Lu, Jazmina L. Gonzalez Cruz, Rabina Giri, Yuexiao Zhang, Sahra Bashiri, Leslie C. Domínguez Cadena, Shuhang Li, Zeinab G. Khalil, Waleed M. Hussein, Jingwen Wang, Jolynn Kiong, Xuehan Lu, Jiahui Zhang, Miao Lu, Wenbin Huang, Wei Yang Kong, Ummey Jannatun Nahar, Prashamsa Koirala, Zhong Guo, Patricia Walden, Antje Blumenthal, Jakob Begun, Kirill Alexandrov, Istvan Toth, Rachel J. Stephenson, Mariusz Skwarczynski   +25 more
wiley   +1 more source

Tuning High Temperature Performance Through Targeted Halide Substitution in a Bis(Imino)Pyridine‐Iron Ethylene Polymerization Catalyst

Journal of Applied Polymer Science, Volume 143, Issue 11, March 15, 2026.
Through systematic developments in catalyst design, we report a series of exceptionally active on iron catalysts for the polymerization of ethylene that can run at high operating temperature forming highly linear polyethylene waxes with narrow dispersity and high levels of vinyl chain ends that could be influenced by the operating temperature.
Elizabeth Ogbe, Yanping Ma, Yizhou Wang, Gregory A. Solan, Qiuyue Zhang, Tongling Liang, Wen‐Hua Sun   +6 more
wiley   +1 more source