Results 21 to 30 of about 6,338 (167)

Synergistic diselenide/guanidine catalyzed dehydrophosphorylation of 2-nitrobenzhydrols to access C-stereogenic phosphinates. [PDF]

Chem Sci
The development of a catalytic and mild variant of the Atherton–Todd reaction for the synthesis of chiral phosphorus-containing compounds presents substantial challenges.
Gong JY, Zhou PP, Qiao YH, Qi ZC, Zuo QM, Fang QX, Yang SD.   +6 more
europepmc   +2 more sources

Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The synthesis of a new series of sulfamides incorporating ortho-, meta, and para-benzenesulfamide moieties is reported, which were investigated for the inhibition of two human (h) isoforms of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I and
Silvia Bua, Emanuela Berrino, Sonia Del Prete, Vallabhaneni S. Murthy, Vijayaparthasarathi Vijayakumar, Yasinalli Tamboli, Clemente Capasso, Elisabetta Cerbai, Alessandro Mugelli, Fabrizio Carta, Claudiu T. Supuran   +10 more
doaj   +1 more source

Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB1R Inverse Agonists.

ACS Medicinal Chemistry Letters, 2020
The 6-benzhydryl-4-amino-quinolin-2-ones are peripherally restricted CB1 receptor inverse agonists (CB1RIAs) that have been reported to attenuate obesity and improve insulin sensitivity in the diet-induced obese (DIO) mouse model. However, chronic dosing
Yue-Mei Zhang, M. Greco, Tonya Le Blanc, Wensheng Lang, J. Kauffman, J. Masucci, W. Murray, K. Demarest, M. Macielag   +8 more
semanticscholar   +1 more source

Rapid and Stereoselective Ring‐Opening Polymerization of rac‐Lactide Enabled by a Chiral Cyclopropenimine–Thiourea Catalyst

Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.
Chiral cyclopropenimine–thiourea organocatalysts enabled both high reactivity and precise stereocontrol in the ring‐opening polymerization of rac‐lactide. The bifunctional system exhibited a TOF up to 1,710 h−1 with Pm = 0.90 at 25°C, and achieved Pm = 0.99 at −78°C while maintaining a TOF of 16.3 h−1.
Sumin Lee, Hooseung Lee, Hyeongwoo Nam, Seungyun Jo, Minseong Kim, Dongwook Kim, Du Yeol Ryu, Sarah Yunmi Lee, Byeong‐Su Kim   +8 more
wiley   +2 more sources

Synthesis, molecular modelling and biological characterization of novel antimigratory and antiinvasive 1-benzhydryl piperazine derivatives [PDF]

, 2021
Human epigenetic metalloenzymes that modulate the acetylation status of histones, alter cancer cell morphology and cell survival are histone deacetylases (HDACs).
Ružić, Dušan, Nikolić, Katarina, Santibanez, Juan, Srdić-Rajić, Tatjana, Ellinger, Bernhard, Petković, Miloš, Gul, Sheraz   +6 more
core  

Regiospecific Syntheses of 6α-(1R-Hydroxyoctyl)penicillanic Acid and 6β-(1R-Hydroxyoctyl)penicillanic Acid as Mechanistic Probes of Class D β-Lactamases

, 2016
The unique hydrophobic surface patches in class D β-lactamases presented an opportunity for designing two compounds, 6α-(1R-hydroxyoctyl)penicillanic acid and 6β-(1R-hydroxyoctyl)penicillanic acid, as mechanistic probes of these enzymes. In a sequence of
Mijoon Lee (1336056), Sebastian A. Testero (1656127), Peter I. O’Daniel (1656133), Qicun Shi (2210413), Shahriar Mobashery (475725), Dusan Hesek (1336062), Akihiro Ishiwata (2140105), Bruce C. Noll (1472230)   +7 more
core   +4 more sources

1-Benzhydryl-3-phenylurea and 1-Benzhydryl-3-phenylthiourea Derivatives:  New Templates among the CB₁ Cannabinoid Receptor Inverse Agonists

, 2016
New 1-benzhydryl-3-phenylurea derivatives and their 1-benzhydryl-3-phenylthiourea isosteres were synthesized and evaluated for their human CB1 and CB2 cannabinoid receptor affinity. These compounds proved to be selective CB1 cannabinoid receptor ligands,
Jacques H. Poupaert (2069590), Johan Wouters (49810), Wolfgang Poppitz (2651602), Gerhard K. E. Scriba (2113489), Giulio G. Muccioli (199353), Didier M. Lambert (199355)   +5 more
core   +1 more source

Photogeneration of Benzhydryl Cations by Near-UV Laser Flash Photolysis of Pyridinium Salts

, 2016
Laser flash irradiation of substituted N-benzhydryl pyridinium salts yields benzhydryl cations (diarylcarbenium ions) and/or benzhydryl radicals (diarylmethyl radicals). The use of 3,4,5-triamino-substituted pyridines as photoleaving groups allowed us to
Johannes Ammer (1353501), Herbert Mayr (1353507), Tobias A. Nigst (2041858)   +2 more
core   +1 more source

Direct C─H Lactonization of Carboxylic Acids Enabled by LMCT Photoactivation

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
We report a photochemical method for oxidative γ‐C─H lactonization of simple carboxylic acid substrates upon LMCT photoactivation. Intriguingly, these conditions suppress the rapid decarboxylation characteristic of oxidized carboxylates, suggesting the intermediacy of metal‐stabilized acyloxy radical instead of the dissociative process typically ...
Kathryn M. Weber, Rodrigo Villanueva, Mihai V. Popescu, Grace A. Lutovsky, Samuel N. Gockel, Robert S. Paton, Tehshik P. Yoon   +6 more
wiley   +2 more sources

Enantioselective Synthesis of a New Class of Stable and Functionalized Cyclopentadienes via CuH‐Catalysis

Angewandte Chemie International Edition, EarlyView.
Cyclopentadienes (CpHs) are fundamental building blocks with widespread applications in chemistry. However, their inherent acidity and isomeric instability have long limited access to chiral variants in an asymmetric fashion. Here, we introduce a CuH‐catalyzed asymmetric transformation that provides an unprecedented entry into a new class of ...
Piero Soppelsa, Riccardo Bellin, Besma Boulila, Francesco Vaghi, Manuel Orlandi   +4 more
wiley   +1 more source