Results 21 to 30 of about 1,580,488 (150)

Photogeneration of Benzhydryl Cations by Near-UV Laser Flash Photolysis of Pyridinium Salts

, 2016
Laser flash irradiation of substituted N-benzhydryl pyridinium salts yields benzhydryl cations (diarylcarbenium ions) and/or benzhydryl radicals (diarylmethyl radicals). The use of 3,4,5-triamino-substituted pyridines as photoleaving groups allowed us to
Johannes Ammer (1353501), Herbert Mayr (1353507), Tobias A. Nigst (2041858)   +2 more
core   +1 more source

SYNTHESIS AND IN-VITRO STUDY OF NOVEL (Z)-1-BENZHYDRYL-4-CINNAMYLPIPERAZINE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS [PDF]

, 2015
Objective: The objective of this study was to synthesize Z- 1-benzhydryl-4-cinnamylpiperazines by novel stereo selective synthetic method and evaluation of their anticancer properties.Methods: A series of novel (Z)-1-benzhydryl-4-cinnamylpiperazine ...
Kiran, K. R., Diwakar, Latha, Shivaprakash, S., Reddy, Chandrasekara G   +3 more
core   +1 more source

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

ACUTE TOXICITY STUDY OF (Z)-1-BENZHYDRYL-4- CINNAMYLPIPERAZINES IN SWISS ALBINO MICE [PDF]

, 2015
 Objective: The objective was to study the acute toxicity of (Z)-1-benzhydryl-4-cinnamylpiperazine derivatives (1a-c) using Swiss Albino mice.Methods: The acute oral and dermal toxicity studies were carried out based on OECD guidelines by adopting fixed
Barman, Anaxee, Diwakar, Latha, GC, REDDY, S, Shivaprakash   +3 more
core   +1 more source

Direct C─H Lactonization of Carboxylic Acids Enabled by LMCT Photoactivation

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
We report a photochemical method for oxidative γ‐C─H lactonization of simple carboxylic acid substrates upon LMCT photoactivation. Intriguingly, these conditions suppress the rapid decarboxylation characteristic of oxidized carboxylates, suggesting the intermediacy of metal‐stabilized acyloxy radical instead of the dissociative process typically ...
Kathryn M. Weber, Rodrigo Villanueva, Mihai V. Popescu, Grace A. Lutovsky, Samuel N. Gockel, Robert S. Paton, Tehshik P. Yoon   +6 more
wiley   +2 more sources

Targeting the Carotid Body Function With Big‐K+‐Channel Blocker ENA‐001 in Opioid‐Induced Respiratory Depression: A Scoping Review

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Opioids, most intravenous anesthetics and various illicit substances can cause fatal respiratory depression by depressing central respiratory networks. ENA‐001, a ventilatory modulator targeting the carotid bodies, has emerged as a potential countermeasure without impairing analgesia or hypnosis.
Jimmy J. Arevalo, Monique van Velzen, Simone C. Jansen, Maarten van Lemmen, Elise Sarton, Albert Dahan, Erik Olofsen, Joseph F. Cotten, Marieke Niesters, Rutger M. van der Schrier   +9 more
wiley   +1 more source

Gallium‐Catalyzed Tandem Carbonyl–Olefin Metathesis/Dehydrogenative Coupling Enables Rapid Access to Cyclopentenes

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
A cationic gallium(III) catalyst enables rapid construction of substituted cyclopentenes via tandem carbonyl‐ene metathesis/Friedel–Crafts coupling. Electronic tuning of alcohol electrophiles allows access to diverse, densely functionalized rings in a single operation.
Arnaud Espied, Djamila Azrou, Alexandre Djurovic, Régis Guillot, Aurélien Alix, Vincent Gandon, Christophe Bour   +6 more
wiley   +1 more source

Brønsted Acid‐Catalyzed Direct N‐Alkylation of Anilines With Alcohols

ChemistrySelect, Volume 11, Issue 22, 11 June 2026.
Brønsted acid‐catalyzed methodology for the alkylation of anilines with alcohols has been developed. The reaction occurs in short reaction time with excellent functional group tolerance. A broad range of aniline and alcohol derivatives generates the desired adducts in good to excellent yields.
Rony Gantous, Yuri Bolshan
wiley   +1 more source

Zwitterionic Penicillin‐Derived Sulfone Inhibitor for Combating β‐Lactamase‐Mediated Antibiotic Resistance

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
Combining enhanced permeability strategies with (2‐pyridyl)methylene substitution in the sulbactam scaffold led to a novel β‐lactamase inhibitor to combat β‐lactamase‐mediated resistance to β‐lactam antibiotics. The studies presented highlight the potential of compound 3 as a next‐generation β‐lactamase inhibitor for combating infections caused by ...
Diana Rodríguez, Emilio Lence, Juan C. Vázquez‐Ucha, Alejandro Beceiro, Concepción González‐Bello   +4 more
wiley   +1 more source

A Gallium(I) β‐Amido‐Imino‐Phosphorane: A Five‐Membered N‐Heterocyclic Gallylene with Enhanced Nucleophilicity

ChemistryEurope, Volume 4, Issue 5, May 2026.
By introducing β‐amino‐imino‐phosphoranes (BAIPs) as a new class of strongly electron‐donating N,N’‐chelates, an N‐heterocyclic gallylene (NHGa) with enhanced nucleophilicity is obtained. The new NHGa is readily synthesized, and the ligand features potent 1H and 31P NMR probes for reaction control.
Aylin Nagel, Samuel R. Lawrence, Tobias Rüffer, Robert Kretschmer   +3 more
wiley   +1 more source