Results 91 to 100 of about 17,199 (170)

2D Materials: From Design and Synthesis to Applications in Electrical and Electrochemical Biosensors

Small, EarlyView.
Various types of 2D materials, encompassing all potential candidates to date, are examined alongside their synthetic methods and functionalization strategies for bioreceptor immobilization. This review highlights approaches for designing and scaling up these materials to enable cost‐effective electrical and electrochemical biosensing applications ...
Masud, Jaeyoon Song, Falguni Ahmed, Jinsik Kim   +3 more
wiley   +1 more source

BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure

Aging Cell, EarlyView.
Transcriptomic and cellular analyses of BubR1 hypomorphic hearts reveal disruptions in key pathways and upregulation of markers linked to impaired cardiac structure and function. Comparative transcriptomic analysis shows that BubR1 insufficiency mirrors changes seen in aged and failing hearts. A key finding of this study is that BubR1 levels decline in
Renju Pun, Aliya L. Haas, Aradhana Thapa, Sylar R. Takafuji, Rexton M. Suzuki, Gabrielle F. Kay, Li Zheng, Michelle Waknitz, Michael H. Kim, Darren J. Baker, Jan M. van Deursen, Paul L. Sorgen, Rebekah L. Gundry, Brian J. North   +13 more
wiley   +1 more source

Structure‐based discovery of thiamine uptake inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel, Björn Windshügel, Christian Löw   +2 more
wiley   +1 more source

Trends in novel opioid use and detections in exposures and police drug seizures in New South Wales

Drug and Alcohol Review, EarlyView.
Abstract Introduction Novel opioids, including non‐medical and non‐opium‐based opioids such as fentanyl analogues and nitazenes, pose a significant risk of harm due to their high potency. There is little published data on novel opioid detections and harms in Australia, yet they are implicated in multiple deaths.
Janette L. Smith, Jared Brown, David Atefi, Thanjira Jiranantakan, Vanessa Shaw, Christopher Ewers, Lorraine du Toit‐Prinsloo, Darren M. Roberts   +7 more
wiley   +1 more source

A Scoping Review of the Emergence of Novel Synthetic Opioids in Australian Drug Markets: What Does This Mean for Harm Reduction Responses?

Drug and Alcohol Review, EarlyView.
ABSTRACT Issues Rising synthetic opioid deaths in North America, and the emergence of nitazene harms has driven concern about novel synthetic opioids (NSO) in Australia. This scoping review aimed to map what is known about NSOs in Australia. Approach Scoping review of peer‐reviewed and grey literature on NSO detections and harms.
Emmanuel Mammoliti, Suzanne Nielsen, Amanda Roxburgh   +2 more
wiley   +1 more source

Searching for a Needle in a Haystack: Chemical Analysis Reveals Nitazenes Found in Drug Paraphernalia Residues

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction A group of synthetic opioids, the nitazenes, is appearing in the illicit drug market. Monitoring these novel psychoactive substances is challenging due to constantly evolving analogues and the small amounts of these potent drugs that are consumed.
Emma L. Keller, Brock Peake, Bradley S. Simpson, Marie Longo, Stephen Trobbiani, Jason M. White, Cobus Gerber   +6 more
wiley   +1 more source

Sustainable control of cyathostomin infections in practice

Equine Veterinary Education, EarlyView.
Summary Cyathostomins are the most prevalent helminths in horses and are found in nearly all grazing groups. These parasites have been shown to exhibit widespread anthelmintic resistance and can cause clinical disease, so they are a growing concern.
J. B. Matthews, T. S. Mair
wiley   +1 more source

Lipedema: Progress, Challenges, and the Road Ahead

Obesity Reviews, EarlyView.
ABSTRACT Introduction Lipedema is a chronic and progressive disease that predominantly affects women, characterized by a disproportionate increase in subcutaneous adipose tissue (AT), particularly in the lower limbs. It is associated with significant physical disability, chronic pain, thromboembolism, and psychosocial distress.
Vincenza Cifarelli
wiley   +1 more source

Overcoming Photochemical Limitations in Covalent Organic Frameworks: Low‐Energy Light Driven Selective 1O2 Generation Achieved by Donor–Acceptor Strategy

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
We demonstrate for the first time that a novel donor–acceptor strategy in covalent organic frameworks (COFs) has been developed to regulate the localized electronic state structures for efficient and selective 1O2 generation under low‐energy light. The engineered COF selectively produced 1O2 under red light through a coupled charge transfer mechanism ...
Jikuan Qiu, Hanping Zhai, Yuling Zhao, Yucheng Jin, Zhiyong Li, Huiyong Wang, Zhongping Li, Jianji Wang, Jong‐Beom Baek   +8 more
wiley   +2 more sources

Chitin Soil Amendment Triggers Systemic Plant Disease Resistance Through Enhanced Pattern‐Triggered Immunity

Plant Biotechnology Journal, EarlyView.
ABSTRACT Chitin triggers localised and systemic plant immune responses, making it a promising treatment for sustainable disease resistance. However, the precise molecular mechanisms underlying chitin‐induced systemic effects in plants remain unknown. In this study, we investigated the effects of soil amendment with crab chitin flakes (hereafter chitin)
Moffat Makechemu, Yukihisa Goto, Marc W. Schmid, Helen Zbinden, Victoria Widrig, Moritz Kaufmann, Joël F. Pothier, Beat Keller, Cyril Zipfel   +8 more
wiley   +1 more source