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Benzimidazoles: Veterinary uses
Parasitology Today, 1990Benzimidazoles are valued for use against helminth infections in domestic animals. Here, Bill Campbell discusses efficacy, dosages, methods of administration and the species of parasite against which they are applied.
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Biochemistry of benzimidazole resistance
Acta Tropica, 1994Heavy reliance on the benzimidazole (BZ) anthelmintics since their introduction in the 1960's for the control of gastrointestinal parasites of livestock has led to widespread BZ resistance in target parasite species. The BZs exert their primary action by binding to tubulin, the major protein component of microtubules.
Jennifer H. Gill, Ernest Lacey
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Oxomolybdenum (V) Complexes of Benzimidazole and 2 - Substituted Benzimidazoles
Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1991Abstract Oxomolybdenum (V) complexes of the type (LH)2-[MoOCl5], (LH)2 [MoOCl4.OH], (LH)MOOCI4.F2O], [Mo2O4cl-(L - H)L′ (H2O)2-].nH2O, (where L = benzimidazole, 2 - α-hydroxymethyl benzimidazole, 2 - α - hydroxyethyl benzimidazole and 2 - α- hydroxybenzyl benzimidazole, L″ = EtOH or H2O and n = O, 1 or 2); [MoOCl3(L)2]H2O, (L = benzimidazole); [MoOCl2 ...
S. R. Girish, Vinayak B. Mahale
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ChemInform, 1988
2H-Benzimidazole-2-spirocyclohexanes (1) when heated undergo a 1,5-sigmatropic rearrangement to 2,3-disubstituted 1H-benzimidazoles. A decided effect on the direction of this Isomerisation was observed with substituents in the homodiene ring.
Hans Suschitzky +3 more
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2H-Benzimidazole-2-spirocyclohexanes (1) when heated undergo a 1,5-sigmatropic rearrangement to 2,3-disubstituted 1H-benzimidazoles. A decided effect on the direction of this Isomerisation was observed with substituents in the homodiene ring.
Hans Suschitzky +3 more
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Mode of action of benzimidazoles
Parasitology Today, 1990Benzimidazoles represent the only class of truly broad-spectrum anthelmintics, however, they also show activity against fungi and mammalian cells. This raises the question as to why benzimidazoles can selectively kill helminths and yet exhibit little or no mammalian toxicity.
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Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin
Biochimica et Biophysica Acta (BBA) - General Subjects, 1978The binding and inhibitory properties of 11 benzimidazoles for bovine brain tubulin were investigated. The effects of the benzimidazoles on the initial rates of microtubule polymerization were determined by a turbidimetric assay. The median inhibitory concentrations (I50) for nocodazole, oxibendazole, parbendazole, mebendazole and fenbendazole ranged ...
Paul A. Friedman, Edward G. Platzer
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J. Chem. Soc., Chem. Commun., 1986
[Fe2S2L2]2– complexes co-ordinated by the mixed-donor N–S, N–O, or N–N ligands L1–L4 are characterised by electronic and n.m.r. spectroscopy and shown to undergo one-electron reduction to the corresponding trianions with e.s.r. spectra exhibiting a range of g-tensor values which are compared with those for [2Fe–2S]+ proteins of the Rieske type.
Peter Beardwood, John F. Gibson
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[Fe2S2L2]2– complexes co-ordinated by the mixed-donor N–S, N–O, or N–N ligands L1–L4 are characterised by electronic and n.m.r. spectroscopy and shown to undergo one-electron reduction to the corresponding trianions with e.s.r. spectra exhibiting a range of g-tensor values which are compared with those for [2Fe–2S]+ proteins of the Rieske type.
Peter Beardwood, John F. Gibson
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ChemInform Abstract: PHOSPHORYLATED BENZIMIDAZOLES. VI. PHOSPHORYLATED IMIDAZOLES AND BENZIMIDAZOLES
Chemischer Informationsdienst, 1981Abstract2‐Formyl‐benzimidazol (I) reagiert mit Anilin (II) und Diethylphosphit (III) zu einem Gemisch der Verbindungen (IV) und (V).
P. M. Zavlin +3 more
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Benzimidazoles in a wormy world
Parasitology Today, 1990The problem of helminth infection is vast by anyone’s reckoning and is of equal interest to the veterinary surgeon and the clinician. To say that helminths are ubiquitous is almost an understatement: as parasites of livestock and humans, they represent the single most important group of infections on the planet, although many separate species are ...
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